SCOPe 2.08: Domain d4grya_: 4gry A:

Lineage for d4grya_ (4gry A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

6. Protein Tyrosine phosphatase [52806] (7 species)

7. Species Human (Homo sapiens), shp-1 [TaxId:9606] [52811] (4 PDB entries)

8. Domain d4grya_: 4gry A: [197014]
   automated match to d1fpra_
   complexed with so4

Details for d4grya_

PDB Entry: 4gry, 1.7 Å

PDB Description: crystal structure of shp1 catalytic domain with so4

PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 6

SCOPe Domain Sequences for d4grya_:

Sequence, based on SEQRES records:

>d4grya_ c.45.1.2 (A:) Tyrosine phosphatase {Human (Homo sapiens), shp-1 [TaxId: 9606]}
gfweefeslqkqevknlhqrlegqrpenkgknryknilpfdhsrvilqgrdsnipgsdyi
nanyiknqllgpdenaktyiasqgcleatvndfwqmawqensrvivmttrevekgrnkcv
pywpevgmqraygpysvtncgehdtteyklrtlqvspldngdlireiwhyqylswpdhgv
psepggvlsfldqinqrqeslphagpiivhssagigrtgtiividmlmenistkgldcdi
diqktiqmvraqrsgmvqteaqykfiyvaiaqfiettkkklev

Sequence, based on observed residues (ATOM records):

>d4grya_ c.45.1.2 (A:) Tyrosine phosphatase {Human (Homo sapiens), shp-1 [TaxId: 9606]}
gfweefeslqkqevknlhqrlegqrpenkgknryknilpfdhsrvilqgrdsnipgsdyi
nanyiknqllnaktyiasqgcleatvndfwqmawqensrvivmttrevpywpevgmqray
gpysvtncgehdtteyklrtlqvspldngdlireiwhyqylswpdhgvpsepggvlsfld
qinqrqeslphagpiivhssagigrtgtiividmlmenistkgldcdidiqktiqmvraq
rsgmvqteaqykfiyvaiaqfiettkkklev

Timeline for d4grya_:

• d4grya_ first appeared in SCOPe 2.02
  
• d4grya_ appears in SCOPe 2.07