PDB entry 7mnb

View 7mnb on RCSB PDB site
Description: PTP1B F225Y-R199N-L195R in complex with TCS401
Class: hydrolase
Keywords: protein tyrosine phosphatase, hydrolase
Deposited on 2021-04-30, released 2022-05-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-05-18, with a file datestamp of 2022-05-13.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein phosphatase non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1, PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (5-305)
      • expression tag (0-4)
      • engineered mutation (199)
      • engineered mutation (203)
      • engineered mutation (229)
      • expression tag (306-307)
    Domains in SCOPe 2.08: d7mnba_
  • Heterogens: OTA, CL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7mnbA (A:)
ghmasmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhs
riklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvme
kgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfh
yttwpdfgvpespasflnfrfkvnesgslspehgpvvvhcsagigrsgtycladtclllm
dkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkels
hedlephn

    Sequence, based on observed residues (ATOM records): (download) 
    >7mnbA (A:)
memekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsriklh
qedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgslk
caqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwp
dfgvpespasflnfrfkvnesgslspehgpvvvhcsagigrsgtycladtclllmdkrkd
pssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkelshed