Lineage for Protein: Dihydropteridin reductase (pteridine reductase)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2426096Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2426097Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2426443Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2426817Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)

Species:

  1. 2426818Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
  2. 2426820Leishmania major [TaxId:5664] [63926] (13 PDB entries)
    Uniprot Q01782
    1. Domains for 1e7w:
      1. 2426821Domain d1e7wa_: 1e7w A: [59373]
        complexed with edo, mtx, ndp
      2. 2426822Domain d1e7wb_: 1e7w B: [59374]
        complexed with edo, mtx, ndp
    2. Domains for 1e92:
      1. 2426823Domain d1e92a_: 1e92 A: [64798]
        complexed with edo, hbi, nap
      2. 2426824Domain d1e92b_: 1e92 B: [64799]
        complexed with edo, hbi, nap
      3. 2426825Domain d1e92c_: 1e92 C: [64800]
        complexed with edo, hbi, nap
      4. 2426826Domain d1e92d_: 1e92 D: [64801]
        complexed with edo, hbi, nap
    3. Domains for 1w0c:
      1. 2426862Domain d1w0ca_: 1w0c A: [114052]
        complexed with nap, taq
      2. 2426863Domain d1w0cb_: 1w0c B: [114053]
        complexed with nap, taq
      3. 2426864Domain d1w0cc_: 1w0c C: [114054]
        complexed with nap, taq
      4. 2426865Domain d1w0cd_: 1w0c D: [114055]
        complexed with nap, taq
      5. 2426866Domain d1w0ce_: 1w0c E: [114056]
        complexed with nap, taq
      6. 2426867Domain d1w0cf_: 1w0c F: [114057]
        complexed with nap, taq
      7. 2426868Domain d1w0cg_: 1w0c G: [114058]
        complexed with nap, taq
      8. 2426869Domain d1w0ch_: 1w0c H: [114059]
        complexed with nap, taq
    4. Domains for 2bf7:
      1. 2426830Domain d2bf7a_: 2bf7 A: [128407]
        automated match to d1e7wa_
        complexed with edo, hbi, nap
      2. 2426831Domain d2bf7b_: 2bf7 B: [128408]
        automated match to d1e7wa_
        complexed with edo, hbi, nap
      3. 2426832Domain d2bf7c_: 2bf7 C: [128409]
        automated match to d1e7wa_
        complexed with edo, hbi, nap
      4. 2426833Domain d2bf7d_: 2bf7 D: [128410]
        automated match to d1e7wa_
        complexed with edo, hbi, nap
    5. Domains for 2bfa:
      1. 2426842Domain d2bfaa_: 2bfa A: [128413]
        automated match to d1e7wa_
        complexed with cb3, edo, ndp
      2. 2426843Domain d2bfab_: 2bfa B: [128414]
        automated match to d1e7wa_
        complexed with cb3, edo, ndp
      3. 2426844Domain d2bfac_: 2bfa C: [128415]
        automated match to d1e7wa_
        complexed with cb3, edo, ndp
      4. 2426845Domain d2bfad_: 2bfa D: [128416]
        automated match to d1e7wa_
        complexed with cb3, edo, ndp
    6. Domains for 2bfm:
      1. 2426850Domain d2bfma_: 2bfm A: [128439]
        automated match to d1e7wa_
        complexed with ndp, top
      2. 2426851Domain d2bfmb_: 2bfm B: [128440]
        automated match to d1e7wa_
        complexed with ndp, top
      3. 2426852Domain d2bfmc_: 2bfm C: [128441]
        automated match to d1e7wa_
        complexed with ndp, top
      4. 2426853Domain d2bfmd_: 2bfm D: [128442]
        automated match to d1e7wa_
        complexed with ndp, top
    7. Domains for 2bfo:
      1. 2426838Domain d2bfoa_: 2bfo A: [128444]
        automated match to d1e7wa_
        complexed with edo, ndp
      2. 2426839Domain d2bfob_: 2bfo B: [128445]
        automated match to d1e7wa_
        complexed with edo, ndp
      3. 2426840Domain d2bfoc_: 2bfo C: [128446]
        automated match to d1e7wa_
        complexed with edo, ndp
      4. 2426841Domain d2bfod_: 2bfo D: [128447]
        automated match to d1e7wa_
        complexed with edo, ndp
    8. Domains for 2bfp:
      1. 2426834Domain d2bfpa_: 2bfp A: [128448]
        automated match to d1e7wa_
        complexed with edo, h4b, nap
      2. 2426835Domain d2bfpb_: 2bfp B: [128449]
        automated match to d1e7wa_
        complexed with edo, h4b, nap
      3. 2426836Domain d2bfpc_: 2bfp C: [128450]
        automated match to d1e7wa_
        complexed with edo, h4b, nap
      4. 2426837Domain d2bfpd_: 2bfp D: [128451]
        automated match to d1e7wa_
        complexed with edo, h4b, nap
    9. Domains for 2p8k:
      1. 2426854Domain d2p8ka_: 2p8k A: [304331]
        automated match to d1e92b_
        complexed with dyp, nap
      2. 2426855Domain d2p8kb_: 2p8k B: [304332]
        automated match to d1e92b_
        complexed with dyp, nap
      3. 2426856Domain d2p8kc_: 2p8k C: [304333]
        automated match to d1e92a_
        complexed with dyp, nap
      4. 2426857Domain d2p8kd_: 2p8k D: [304334]
        automated match to d1e92b_
        complexed with dyp, nap
      5. 2426858Domain d2p8ke_: 2p8k E: [304335]
        automated match to d1e92a_
        complexed with dyp, nap
      6. 2426859Domain d2p8kf_: 2p8k F: [304336]
        automated match to d1e92b_
        complexed with dyp, nap
      7. 2426860Domain d2p8kg_: 2p8k G: [304337]
        automated match to d1e92a_
        complexed with dyp, nap
      8. 2426861Domain d2p8kh_: 2p8k H: [304338]
        automated match to d1e92b_
        complexed with dyp, nap
    10. Domains for 2qhx:
      1. 2426827Domain d2qhxa1: 2qhx A:5-288 [150796]
        Other proteins in same PDB: d2qhxc_
        automatically matched to d1e7wa_
        complexed with fe1, iod, nap
      2. 2426828Domain d2qhxb1: 2qhx B:5-288 [150797]
        Other proteins in same PDB: d2qhxc_
        automatically matched to d1e7wa_
        complexed with fe1, iod, nap
      3. 2426829Domain d2qhxd_: 2qhx D: [150799]
        Other proteins in same PDB: d2qhxc_
        automated match to d1p33b_
        complexed with fe1, iod, nap
    11. Domains for 3h4v:
      1. 2426874Domain d3h4va_: 3h4v A: [177181]
        automated match to d1e7wa_
        complexed with dvp, nap
      2. 2426875Domain d3h4vb_: 3h4v B: [177182]
        automated match to d1e7wa_
        complexed with dvp, nap
      3. 2426876Domain d3h4vc_: 3h4v C: [177183]
        automated match to d1e7wa_
        complexed with dvp, nap
      4. 2426877Domain d3h4vd_: 3h4v D: [177184]
        automated match to d1e7wa_
        complexed with dvp, nap
      5. 2426878Domain d3h4ve_: 3h4v E: [177185]
        automated match to d1e7wa_
        complexed with dvp, nap
      6. 2426879Domain d3h4vf_: 3h4v F: [177186]
        automated match to d1e7wa_
        complexed with dvp, nap
      7. 2426880Domain d3h4vg_: 3h4v G: [177187]
        automated match to d1e7wa_
        complexed with dvp, nap
      8. 2426881Domain d3h4vh_: 3h4v H: [177188]
        automated match to d1e7wa_
        complexed with dvp, nap
    12. Domains for 5l42:
      1. 2426846Domain d5l42a_: 5l42 A: [339580]
        automated match to d1e92b_
        complexed with 6j6, act, edo, gol, ndp, pge
      2. 2426847Domain d5l42b_: 5l42 B: [339538]
        automated match to d1e92b_
        complexed with 6j6, act, edo, gol, ndp, pge
      3. 2426848Domain d5l42c_: 5l42 C: [339555]
        automated match to d1e92b_
        complexed with 6j6, act, edo, gol, ndp, pge
      4. 2426849Domain d5l42d_: 5l42 D: [339552]
        automated match to d1e92b_
        complexed with 6j6, act, edo, gol, ndp, pge
    13. Domains for 5l4n:
      1. 2426870Domain d5l4na_: 5l4n A: [331675]
        automated match to d1e92b_
        complexed with 6qt, act, edo, gol, ndp, peg, pge
      2. 2426871Domain d5l4nb_: 5l4n B: [331667]
        automated match to d1e92b_
        complexed with 6qt, act, edo, gol, ndp, peg, pge
      3. 2426872Domain d5l4nc_: 5l4n C: [331681]
        automated match to d1e92b_
        complexed with 6qt, act, edo, gol, ndp, peg, pge
      4. 2426873Domain d5l4nd_: 5l4n D: [331672]
        automated match to d1e92b_
        complexed with 6qt, act, edo, gol, ndp, peg, pge
  3. 2426882Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
  4. 2426887Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
  5. 2426890Norway rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    1. Domain for 1dhr:
    2. Domains for 1dir:
      1. 2426892Domain d1dira_: 1dir A: [29833]
        complexed with nad
      2. 2426893Domain d1dirb_: 1dir B: [29834]
        complexed with nad
      3. 2426894Domain d1dirc_: 1dir C: [29835]
        complexed with nad
      4. 2426895Domain d1dird_: 1dir D: [29836]
        complexed with nad
  6. 2426896Trypanosoma brucei [TaxId:5702] [226783] (15 PDB entries)
    1. Domains for 3bmc:
      1. 2426953Domain d3bmca_: 3bmc A: [208663]
        automated match to d1p33a_
        complexed with fol, nap
      2. 2426954Domain d3bmcb_: 3bmc B: [208664]
        automated match to d1p33a_
        complexed with fol, nap
      3. 2426955Domain d3bmcc_: 3bmc C: [208665]
        automated match to d1p33a_
        complexed with fol, nap
      4. 2426956Domain d3bmcd_: 3bmc D: [208666]
        automated match to d1p33a_
        complexed with fol, nap
    2. Domains for 3bmn:
      1. 2426925Domain d3bmna_: 3bmn A: [208667]
        automated match to d1p33a_
        complexed with act, ax3, edo, gol, nap
      2. 2426926Domain d3bmnb_: 3bmn B: [208668]
        automated match to d1p33a_
        complexed with act, ax3, edo, gol, nap
      3. 2426927Domain d3bmnc_: 3bmn C: [208669]
        automated match to d1p33a_
        complexed with act, ax3, edo, gol, nap
      4. 2426928Domain d3bmnd_: 3bmn D: [208670]
        automated match to d1p33a_
        complexed with act, ax3, edo, gol, nap
    3. Domains for 3bmo:
      1. 2426897Domain d3bmoa_: 3bmo A: [208671]
        automated match to d1p33a_
        complexed with act, ax4, d1d, dtt, gol, na, nap
      2. 2426898Domain d3bmob_: 3bmo B: [208672]
        automated match to d1p33a_
        complexed with act, ax4, d1d, dtt, gol, na, nap
      3. 2426899Domain d3bmoc_: 3bmo C: [208673]
        automated match to d1p33a_
        complexed with act, ax4, d1d, dtt, gol, na, nap
      4. 2426900Domain d3bmod_: 3bmo D: [208674]
        automated match to d1p33a_
        complexed with act, ax4, d1d, dtt, gol, na, nap
    4. Domains for 3bmq:
      1. 2426905Domain d3bmqa_: 3bmq A: [208675]
        automated match to d1p33a_
        complexed with act, ax5, dtt, gol, nap
      2. 2426906Domain d3bmqb_: 3bmq B: [208676]
        automated match to d1p33a_
        complexed with act, ax5, dtt, gol, nap
      3. 2426907Domain d3bmqc_: 3bmq C: [208677]
        automated match to d1p33a_
        complexed with act, ax5, dtt, gol, nap
      4. 2426908Domain d3bmqd_: 3bmq D: [208678]
        automated match to d1p33a_
        complexed with act, ax5, dtt, gol, nap
    5. Domains for 3gn1:
      1. 2426921Domain d3gn1a_: 3gn1 A: [210599]
        automated match to d1p33a_
        complexed with act, ax7, nap
      2. 2426922Domain d3gn1b_: 3gn1 B: [210600]
        automated match to d1p33a_
        complexed with act, ax7, nap
      3. 2426923Domain d3gn1c_: 3gn1 C: [210601]
        automated match to d1p33a_
        complexed with act, ax7, nap
      4. 2426924Domain d3gn1d_: 3gn1 D: [210602]
        automated match to d1p33a_
        complexed with act, ax7, nap
    6. Domains for 3gn2:
      1. 2426901Domain d3gn2a_: 3gn2 A: [210603]
        automated match to d1p33a_
        complexed with act, ax8, nap
      2. 2426902Domain d3gn2b_: 3gn2 B: [210604]
        automated match to d1p33a_
        complexed with act, ax8, nap
      3. 2426903Domain d3gn2c_: 3gn2 C: [210605]
        automated match to d1p33a_
        complexed with act, ax8, nap
      4. 2426904Domain d3gn2d_: 3gn2 D: [210606]
        automated match to d1p33a_
        complexed with act, ax8, nap
    7. Domains for 3mcv:
      1. 2426909Domain d3mcva_: 3mcv A: [213206]
        automated match to d1p33a_
        complexed with act, mcv, nap
      2. 2426910Domain d3mcvb_: 3mcv B: [213207]
        automated match to d1p33a_
        complexed with act, mcv, nap
      3. 2426911Domain d3mcvc_: 3mcv C: [213208]
        automated match to d1p33a_
        complexed with act, mcv, nap
      4. 2426912Domain d3mcvd_: 3mcv D: [213209]
        automated match to d1p33a_
        complexed with act, mcv, nap
    8. Domains for 4wcd:
      1. 2426929Domain d4wcda_: 4wcd A: [277601]
        automated match to d3bmob_
        complexed with 3kh, act, gol, nap
      2. 2426930Domain d4wcdb_: 4wcd B: [277602]
        automated match to d3bmob_
        complexed with 3kh, act, gol, nap
      3. 2426931Domain d4wcdc_: 4wcd C: [277600]
        automated match to d3bmob_
        complexed with 3kh, act, gol, nap
      4. 2426932Domain d4wcdd_: 4wcd D: [277603]
        automated match to d3bmob_
        complexed with 3kh, act, gol, nap
    9. Domains for 4wcf:
      1. 2426949Domain d4wcfa_: 4wcf A: [277330]
        automated match to d3bmob_
        complexed with 3kn, act, gol, nap
      2. 2426950Domain d4wcfb_: 4wcf B: [277329]
        automated match to d3bmob_
        complexed with 3kn, act, gol, nap
      3. 2426951Domain d4wcfc_: 4wcf C: [277328]
        automated match to d3bmob_
        complexed with 3kn, act, gol, nap
      4. 2426952Domain d4wcfd_: 4wcf D: [277332]
        automated match to d3bmob_
        complexed with 3kn, act, gol, nap
    10. Domains for 5izc:
      1. 2426945Domain d5izca_: 5izc A: [332653]
        automated match to d3bmob_
        complexed with 6f4, act, gol, nap
      2. 2426946Domain d5izcb_: 5izc B: [332542]
        automated match to d3bmob_
        complexed with 6f4, act, gol, nap
      3. 2426947Domain d5izcc_: 5izc C: [332605]
        automated match to d3bmob_
        complexed with 6f4, act, gol, nap
      4. 2426948Domain d5izcd_: 5izc D: [332565]
        automated match to d3bmob_
        complexed with 6f4, act, gol, nap
    11. Domains for 5jcj:
      1. 2426937Domain d5jcja_: 5jcj A: [321414]
        automated match to d3bmob_
        complexed with 6jm, act, nap
      2. 2426938Domain d5jcjb_: 5jcj B: [321406]
        automated match to d3bmob_
        complexed with 6jm, act, nap
      3. 2426939Domain d5jcjc_: 5jcj C: [321501]
        automated match to d3bmob_
        complexed with 6jm, act, nap
      4. 2426940Domain d5jcjd_: 5jcj D: [321473]
        automated match to d3bmob_
        complexed with 6jm, act, nap
    12. Domains for 5jcx:
      1. 2426917Domain d5jcxa_: 5jcx A: [321429]
        automated match to d3bmob_
        complexed with act, cc6, gol, nap
      2. 2426918Domain d5jcxb_: 5jcx B: [321466]
        automated match to d3bmob_
        complexed with act, cc6, gol, nap
      3. 2426919Domain d5jcxc_: 5jcx C: [321413]
        automated match to d3bmob_
        complexed with act, cc6, gol, nap
      4. 2426920Domain d5jcxd_: 5jcx D: [321430]
        automated match to d3bmob_
        complexed with act, cc6, gol, nap
    13. Domains for 5jdc:
      1. 2426941Domain d5jdca_: 5jdc A: [321388]
        automated match to d3bmob_
        complexed with 6jp, act, gol, nap
      2. 2426942Domain d5jdcb_: 5jdc B: [321485]
        automated match to d3bmob_
        complexed with 6jp, act, gol, nap
      3. 2426943Domain d5jdcc_: 5jdc C: [321389]
        automated match to d3bmob_
        complexed with 6jp, act, gol, nap
      4. 2426944Domain d5jdcd_: 5jdc D: [321457]
        automated match to d3bmob_
        complexed with 6jp, act, gol, nap
    14. Domains for 5jdi:
      1. 2426913Domain d5jdia_: 5jdi A: [321381]
        automated match to d3bmob_
        complexed with 6jo, act, nap
      2. 2426914Domain d5jdib_: 5jdi B: [321420]
        automated match to d3bmob_
        complexed with 6jo, act, nap
      3. 2426915Domain d5jdic_: 5jdi C: [321449]
        automated match to d3bmob_
        complexed with 6jo, act, nap
      4. 2426916Domain d5jdid_: 5jdi D: [321450]
        automated match to d3bmob_
        complexed with 6jo, act, nap
    15. Domains for 5k6a:
      1. 2426933Domain d5k6aa_: 5k6a A: [331674]
        automated match to d3bmob_
        complexed with 6qt, act, nap
      2. 2426934Domain d5k6ab_: 5k6a B: [331660]
        automated match to d3bmob_
        complexed with 6qt, act, nap
      3. 2426935Domain d5k6ac_: 5k6a C: [331682]
        automated match to d3bmob_
        complexed with 6qt, act, nap
      4. 2426936Domain d5k6ad_: 5k6a D: [331771]
        automated match to d3bmob_
        complexed with 6qt, act, nap
  7. 2426957Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
    1. Domains for 1mxf:
      1. 2426962Domain d1mxfa_: 1mxf A: [91486]
        complexed with mtx, ndp
      2. 2426963Domain d1mxfb_: 1mxf B: [91487]
        complexed with mtx, ndp
      3. 2426964Domain d1mxfc_: 1mxf C: [91488]
        complexed with mtx, ndp
      4. 2426965Domain d1mxfd_: 1mxf D: [91489]
        complexed with mtx, ndp
    2. Domains for 1mxh:
      1. 2426958Domain d1mxha_: 1mxh A: [91490]
        complexed with dhf, nap
      2. 2426959Domain d1mxhb_: 1mxh B: [91491]
        complexed with dhf, nap
      3. 2426960Domain d1mxhc_: 1mxh C: [91492]
        complexed with dhf, nap
      4. 2426961Domain d1mxhd_: 1mxh D: [91493]
        complexed with dhf, nap

More info for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Dihydropteridin reductase (pteridine reductase) from c.2.1.2: Tyrosine-dependent oxidoreductases: