Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Domains:

  1. 2090554(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 2090560(s)-1-phenylethanol dehydrogenase [141902] (1 species)
  3. 20905651,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  4. 20905681,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  5. 209058011-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
    1. 2090581Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (4 PDB entries)
      Uniprot Q6QLL4 23-296
    2. 2090596Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
      Uniprot P28845
    3. 2090702Species Mouse (Mus musculus) [TaxId:10090] [141879] (6 PDB entries)
      Uniprot P50172 24-298
  6. 209072115-hydroxyprostaglandin dehydrogenase, PGDH [141888] (1 species)
  7. 209072417-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)
  8. 20907282,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)
  9. 20907423-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  10. 20907523-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  11. 20907583beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  12. 20907647-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  13. 2090772ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  14. 2090784Aldehyde reductase II [117413] (1 species)
  15. 2090792Bacterial sepiapterin reductase [141892] (1 species)
  16. 2090798beta-keto acyl carrier protein reductase [51788] (8 species)
    1. 2090799Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)
    2. 2090814Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141877] (1 PDB entry)
      Uniprot Q86RB1 54-304
    3. 2090816Species Mycobacterium tuberculosis [TaxId:1773] [141875] (2 PDB entries)
      Uniprot P0A5Y4 9-245! Uniprot P0A5Y4 9-247
    4. 2090819Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (2 PDB entries)
    5. 2090827Species Streptomyces coelicolor [TaxId:1902] [117408] (8 PDB entries)
      Uniprot P16544 #SP
    6. 2090844Species Thermotoga maritima [TaxId:2336] [102150] (1 PDB entry)
      TM1169
    7. 2090849Species Thermus thermophilus [TaxId:274] [117407] (1 PDB entry)
      Uniprot Q5SK98
    8. 2090858Species Thermus thermophilus, TTHB020 [TaxId:274] [141876] (1 PDB entry)
      Uniprot Q53WH2 2-242
  17. 2090861Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  18. 2090868Carbonyl reductase [51765] (2 species)
    1. 2090869Species Human (Homo sapiens) [TaxId:9606] [102144] (1 PDB entry)
      dicarbonyl/L-xylulose reductase
    2. 2090872Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)
  19. 2090877Carbonyl reductase sniffer [110413] (2 species)
    1. 2090878Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [110414] (1 PDB entry)
      Uniprot Q9W3H4 # cg10964-pa
    2. 2090880Species Nematode (Caenorhabditis elegans) [TaxId:6239] [186880] (1 PDB entry)
  20. 2090886Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (2 species)
    1. 2090887Species Human (Homo sapiens) [TaxId:9606] [141878] (6 PDB entries)
      Uniprot P16152 2-276
    2. 2090897Species Pig (Sus scrofa) [TaxId:9823] [63936] (2 PDB entries)
  21. 2090900CDP-glucose-4,6-dehydratase [102136] (3 species)
    1. 2090901Species Salmonella enterica [TaxId:220341] [190019] (1 PDB entry)
    2. 2090903Species Salmonella typhimurium [TaxId:90371] [141873] (1 PDB entry)
      Uniprot P26397 2-356
    3. 2090905Species Yersinia pseudotuberculosis [TaxId:633] [102137] (1 PDB entry)
  22. 2090910CDP-tyvelose-2-epimerase [102138] (1 species)
  23. 2090916Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  24. 2090919D(-)-3-hydroxybutyrate dehydrogenase [141886] (1 species)
  25. 2090922Dehydrogenase/reductase SDR family member 6, DHRS6 [141894] (1 species)
    Oxidoreductase UCPA
  26. 2090925Dihydropteridin reductase (pteridine reductase) [51769] (7 species)
    1. 2090926Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 2090928Species Leishmania major [TaxId:5664] [63926] (13 PDB entries)
      Uniprot Q01782
    3. 2090982Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
    4. 2090987Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    5. 2090990Species Norway rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    6. 2090996Species Trypanosoma brucei [TaxId:5702] [226783] (15 PDB entries)
    7. 2091033Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  27. 2091042Drosophila alcohol dehydrogenase [51782] (2 species)
    1. 2091043Species Fly (Drosophila lebanonensis) [TaxId:7225] [51783] (8 PDB entries)
    2. 2091063Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)
  28. 2091066DTDP-4-dehydrorhamnose reductase RfbD [110409] (1 species)
  29. 2091071dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (2 species)
    1. 2091072Species Salmonella enterica [311157] (1 PDB entry)
    2. 2091074Species Salmonella typhimurium [TaxId:90371] [75103] (4 PDB entries)
  30. 2091079dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)
    1. 2091080Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 2091083Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 2091088Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)
    4. 2091101Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)
  31. 2091104Enoyl-ACP reductase [51791] (11 species)
    1. 2091105Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [188487] (1 PDB entry)
    2. 2091110Species Bacillus cereus [TaxId:226900] [192761] (2 PDB entries)
    3. 2091115Species Bacillus subtilis [TaxId:1423] [189591] (2 PDB entries)
    4. 2091121Species Escherichia coli [TaxId:562] [51794] (13 PDB entries)
    5. 2091158Species Helicobacter pylori [TaxId:210] [102151] (4 PDB entries)
    6. 2091172Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (23 PDB entries)
      Uniprot Q9BJJ9 96-424 # fragment
    7. 2091220Species Mycobacterium leprae [TaxId:1769] [187924] (1 PDB entry)
    8. 2091223Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (70 PDB entries)
    9. 2091367Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    10. 2091373Species Staphylococcus aureus [TaxId:1280] [189086] (3 PDB entries)
    11. 2091381Species Thermus thermophilus [TaxId:274] [117409] (1 PDB entry)
      Uniprot Q5SLI9
  32. 2091386Erythromycin synthase, eryAI, 1st ketoreductase module [141909] (1 species)
    tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
  33. 2091392GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  34. 2091402GDP-mannose 4,6-dehydratase [51759] (4 species)
    1. 2091403Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 2091405Species Human (Homo sapiens) [TaxId:9606] [102135] (3 PDB entries)
    3. 2091410Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
    4. 2091415Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  35. 2091422GDP-mannose-3', 5'-epimerase [141890] (1 species)
  36. 2091428Gluconate 5-dehydrogenase [110411] (1 species)
  37. 2091432Glucose dehydrogenase [51784] (1 species)
  38. 2091450Glucose dehydrogenase (5l265) [102155] (1 species)
  39. 2091453Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
  40. 2091485Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  41. 2091517Hypothetical protein At5g02240 (T7H20_290) [117417] (1 species)
  42. 2091527Hypothetical protein F25D1.5 [110415] (1 species)
  43. 2091531Hypothetical protein PA4017 [141911] (1 species)
    unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
  44. 2091535Hypothetical protein R05D8.7 [117415] (1 species)
  45. 2091541Hypothetical protein TTHA0369 [141896] (1 species)
    TT0321
  46. 2091544Levodione reductase [89523] (1 species)
  47. 2091554Mannitol dehydrogenase [63927] (1 species)
  48. 2091568meso-2,3-butanediol dehydrogenase [51786] (1 species)
  49. 2091578Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  50. 2091587Peroxisomal multifunctional enzyme type 2 [141900] (1 species)
    17-beta-hydroxysteroid dehydrogenase 4
  51. 2091595Peroxisomal trans 2-enoyl CoA reductase [141884] (1 species)
  52. 2091601Phenylcoumaran benzylic ether reductase [102140] (1 species)
  53. 2091605Pinoresinol-lariciresinol reductase [102142] (1 species)
  54. 2091611Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
  55. 2091629Putative carbonyl reductase sniffer [141913] (1 species)
  56. 2091632Putative dehydrogenase ARPG836 (MGC4172) [117411] (1 species)
  57. 2091638Putative oxidoreductase Rv2002 [82292] (1 species)
  58. 2091650R-specific alcohol dehydrogenase [89521] (1 species)
  59. 2091654Retinal dehydrogenase/reductase 3 [141907] (1 species)
  60. 2091657Rhizome secoisolariciresinol dehydrogenase [141898] (1 species)
  61. 2091660Sepiapterin reductase [51767] (2 species)
    1. 2091661Species Human (Homo sapiens) [TaxId:9606] [141874] (6 PDB entries)
      Uniprot P35270 5-261
    2. 2091688Species Mouse (Mus musculus) [TaxId:10090] [51768] (3 PDB entries)
  62. 2091692Sorbitol dehydrogenase [102148] (1 species)
  63. 2091696Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  64. 2091702TAT-interacting protein TIP30 [141904] (2 species)
    1. 2091703Species Human (Homo sapiens) [TaxId:9606] [141905] (1 PDB entry)
      Uniprot Q9BUP3 5-236
    2. 2091705Species Mouse (Mus musculus) [TaxId:10090] [141906] (1 PDB entry)
      Uniprot Q9Z2G9 7-236
  65. 2091707Tropinone reductase [51795] (3 species)
    1. 2091708Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 2091711Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
    3. 2091719Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117410] (1 PDB entry)
      Uniprot Q9ASX2
  66. 2091721Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)
    1. 2091722Species Human (Homo sapiens) [TaxId:9606] [102152] (2 PDB entries)
      Uniprot Q99714
    2. 2091728Species Norway rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    3. 2091741Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  67. 2091744UDP-glucuronate decarboxylase 1 [141880] (1 species)
  68. 2091747UDP-N-acetylglucosamine 4-epimerase WbpP [110407] (1 species)
  69. 2091751Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)
    1. 2091752Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [141872] (1 PDB entry)
      Uniprot P04397 11-357
      N-terminal domain of bifunctional Gal10 protein
    2. 2091754Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    3. 2091773Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    4. 2091787Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [89519] (1 PDB entry)
  70. 2091792Xylitol dehydrogenase [141882] (1 species)
  71. 2091795automated matches [190085] (51 species)
    not a true protein
    1. 2091796Species Acinetobacter baumannii [TaxId:470] [272807] (1 PDB entry)
    2. 2091798Species Alcaligenes faecalis [TaxId:511] [188427] (11 PDB entries)
    3. 2091826Species Alfalfa (Medicago sativa) [TaxId:3879] [187740] (1 PDB entry)
    4. 2091829Species Aquifex aeolicus [TaxId:224324] [188271] (2 PDB entries)
    5. 2091838Species Bacillus anthracis [TaxId:198094] [188031] (1 PDB entry)
    6. 2091847Species Bacillus megaterium [TaxId:1404] [195340] (5 PDB entries)
    7. 2091860Species Burkholderia pseudomallei [TaxId:272560] [279838] (11 PDB entries)
    8. 2091862Species Burkholderia pseudomallei [TaxId:320372] [188614] (3 PDB entries)
    9. 2091870Species Burkholderia pseudomallei [TaxId:884204] [238338] (1 PDB entry)
    10. 2091872Species Chlamydia trachomatis [TaxId:1340853] [257638] (1 PDB entry)
    11. 2091881Species Comamonas testosteroni [TaxId:285] [189779] (3 PDB entries)
    12. 2091888Species Eimeria tenella [TaxId:413949] [187997] (1 PDB entry)
    13. 2091891Species Emericella nidulans [TaxId:162425] [187249] (3 PDB entries)
    14. 2091916Species Escherichia coli K-12 [TaxId:83333] [189924] (3 PDB entries)
    15. 2091923Species Escherichia coli [TaxId:469008] [256724] (3 PDB entries)
    16. 2091930Species Escherichia coli [TaxId:562] [255679] (2 PDB entries)
    17. 2091961Species Francisella tularensis [TaxId:177416] [189289] (1 PDB entry)
    18. 2091966Species Francisella tularensis [TaxId:263] [188795] (1 PDB entry)
    19. 2091971Species Human (Homo sapiens) [TaxId:9606] [186828] (23 PDB entries)
    20. 2092010Species Klebsiella pneumoniae [TaxId:573] [276380] (1 PDB entry)
    21. 2092013Species Lactobacillus brevis [TaxId:1580] [186912] (6 PDB entries)
    22. 2092027Species Leishmania donovani [TaxId:5661] [189607] (1 PDB entry)
    23. 2092030Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [186807] (1 PDB entry)
    24. 2092032Species Mycobacterium tuberculosis [TaxId:83332] [229356] (1 PDB entry)
    25. 2092039Species Neisseria meningitidis [TaxId:272831] [228105] (3 PDB entries)
    26. 2092046Species Pandoraea pnomenusa [TaxId:93220] [189780] (3 PDB entries)
    27. 2092053Species Plasmodium berghei [TaxId:5821] [189246] (1 PDB entry)
    28. 2092058Species Plasmodium falciparum [TaxId:36329] [228763] (2 PDB entries)
    29. 2092063Species Plesiomonas shigelloides [TaxId:703] [189972] (9 PDB entries)
    30. 2092098Species Pseudomonas aeruginosa, PA01 [TaxId:208964] [261223] (2 PDB entries)
    31. 2092119Species Pseudomonas fragi [TaxId:296] [188080] (6 PDB entries)
    32. 2092138Species Pseudomonas putida [TaxId:303] [188252] (3 PDB entries)
    33. 2092155Species Rhizobium radiobacter [TaxId:358] [197100] (3 PDB entries)
    34. 2092162Species Sinorhizobium meliloti [TaxId:266834] [195628] (1 PDB entry)
    35. 2092167Species Staphylococcus aureus [TaxId:282458] [193773] (1 PDB entry)
    36. 2092169Species Streptomyces coelicolor [TaxId:1902] [189970] (5 PDB entries)
    37. 2092180Species Streptomyces griseoruber [TaxId:1943] [196180] (1 PDB entry)
    38. 2092183Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [187183] (5 PDB entries)
    39. 2092189Species Thermus thermophilus HB8 [TaxId:300852] [187188] (4 PDB entries)
    40. 2092210Species Thermus thermophilus [TaxId:274] [187600] (1 PDB entry)
    41. 2092214Species Toxoplasma gondii [TaxId:383379] [187942] (3 PDB entries)
    42. 2092225Species Toxoplasma gondii [TaxId:5811] [261808] (1 PDB entry)
    43. 2092228Species Trypanosoma brucei [TaxId:5702] [187520] (4 PDB entries)
    44. 2092245Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [187036] (1 PDB entry)
    45. 2092250Species Vibrio cholerae [TaxId:243277] [189479] (8 PDB entries)
    46. 2092265Species Vibrio cholerae [TaxId:593588] [189768] (3 PDB entries)
    47. 2092276Species Yersinia pestis [TaxId:632] [279426] (2 PDB entries)
    48. 2274813Species Narcissus pseudonarcissus [TaxId:39639] [318114] (2 PDB entries)
    49. 2283377Species Escherichia coli [TaxId:83333] [326678] (1 PDB entry)
    50. 2286710Species Burkholderia pseudomallei [TaxId:28450] [330011] (1 PDB entry)
    51. 2289498Species Naegleria fowleri [TaxId:5763] [332799] (1 PDB entry)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: