Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2426096Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2426097Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2426443Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Domains:

  1. 2426444(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 2426450(s)-1-phenylethanol dehydrogenase [141902] (1 species)
  3. 24264551,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  4. 24264581,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  5. 242647011-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
    1. 2426471Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (4 PDB entries)
      Uniprot Q6QLL4 23-296
    2. 2426486Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
      Uniprot P28845
    3. 2426592Species Mouse (Mus musculus) [TaxId:10090] [141879] (6 PDB entries)
      Uniprot P50172 24-298
  6. 242661315-hydroxyprostaglandin dehydrogenase, PGDH [141888] (1 species)
  7. 242661617-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)
  8. 24266202,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)
  9. 24266343-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  10. 24266443-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  11. 24266503beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  12. 24266567-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  13. 2426664ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  14. 2426676Aldehyde reductase II [117413] (1 species)
  15. 2426684Bacterial sepiapterin reductase [141892] (1 species)
  16. 2426690beta-keto acyl carrier protein reductase [51788] (8 species)
    1. 2426691Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)
    2. 2426706Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141877] (1 PDB entry)
      Uniprot Q86RB1 54-304
    3. 2426708Species Mycobacterium tuberculosis [TaxId:1773] [141875] (2 PDB entries)
      Uniprot P0A5Y4 9-245! Uniprot P0A5Y4 9-247
    4. 2426711Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (2 PDB entries)
    5. 2426719Species Streptomyces coelicolor [TaxId:1902] [117408] (8 PDB entries)
      Uniprot P16544 #SP
    6. 2426736Species Thermotoga maritima [TaxId:2336] [102150] (1 PDB entry)
      TM1169
    7. 2426741Species Thermus thermophilus [TaxId:274] [117407] (1 PDB entry)
      Uniprot Q5SK98
    8. 2426750Species Thermus thermophilus, TTHB020 [TaxId:274] [141876] (1 PDB entry)
      Uniprot Q53WH2 2-242
  17. 2426753Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  18. 2426760Carbonyl reductase [51765] (2 species)
    1. 2426761Species Human (Homo sapiens) [TaxId:9606] [102144] (1 PDB entry)
      dicarbonyl/L-xylulose reductase
    2. 2426764Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)
  19. 2426769Carbonyl reductase sniffer [110413] (2 species)
    1. 2426770Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [110414] (1 PDB entry)
      Uniprot Q9W3H4 # cg10964-pa
    2. 2426772Species Nematode (Caenorhabditis elegans) [TaxId:6239] [186880] (1 PDB entry)
  20. 2426778Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (2 species)
    1. 2426779Species Human (Homo sapiens) [TaxId:9606] [141878] (6 PDB entries)
      Uniprot P16152 2-276
    2. 2426789Species Pig (Sus scrofa) [TaxId:9823] [63936] (2 PDB entries)
  21. 2426792CDP-glucose-4,6-dehydratase [102136] (3 species)
    1. 2426793Species Salmonella enterica [TaxId:220341] [190019] (1 PDB entry)
    2. 2426795Species Salmonella typhimurium [TaxId:90371] [141873] (1 PDB entry)
      Uniprot P26397 2-356
    3. 2426797Species Yersinia pseudotuberculosis [TaxId:633] [102137] (1 PDB entry)
  22. 2426802CDP-tyvelose-2-epimerase [102138] (1 species)
  23. 2426808Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  24. 2426811D(-)-3-hydroxybutyrate dehydrogenase [141886] (1 species)
  25. 2426814Dehydrogenase/reductase SDR family member 6, DHRS6 [141894] (1 species)
    Oxidoreductase UCPA
  26. 2426817Dihydropteridin reductase (pteridine reductase) [51769] (7 species)
    1. 2426818Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 2426820Species Leishmania major [TaxId:5664] [63926] (13 PDB entries)
      Uniprot Q01782
    3. 2426882Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
    4. 2426887Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    5. 2426890Species Norway rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    6. 2426896Species Trypanosoma brucei [TaxId:5702] [226783] (15 PDB entries)
    7. 2426957Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  27. 2426966Drosophila alcohol dehydrogenase [51782] (2 species)
    1. 2426967Species Fly (Drosophila lebanonensis) [TaxId:7225] [51783] (8 PDB entries)
    2. 2426987Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)
  28. 2426990DTDP-4-dehydrorhamnose reductase RfbD [110409] (1 species)
  29. 2426995dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (2 species)
    1. 2426996Species Salmonella enterica [311157] (1 PDB entry)
    2. 2426998Species Salmonella typhimurium [TaxId:90371] [75103] (4 PDB entries)
  30. 2427003dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)
    1. 2427004Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 2427007Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 2427012Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)
    4. 2427025Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)
  31. 2427028Enoyl-ACP reductase [51791] (11 species)
    1. 2427029Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [188487] (1 PDB entry)
    2. 2427034Species Bacillus cereus [TaxId:226900] [192761] (6 PDB entries)
    3. 2427039Species Bacillus subtilis [TaxId:1423] [189591] (2 PDB entries)
    4. 2427045Species Escherichia coli [TaxId:562] [51794] (13 PDB entries)
    5. 2427082Species Helicobacter pylori [TaxId:210] [102151] (4 PDB entries)
    6. 2427097Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (23 PDB entries)
      Uniprot Q9BJJ9 96-424 # fragment
    7. 2427145Species Mycobacterium leprae [TaxId:1769] [187924] (1 PDB entry)
    8. 2427148Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (84 PDB entries)
    9. 2427317Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    10. 2427323Species Staphylococcus aureus [TaxId:1280] [189086] (3 PDB entries)
    11. 2427331Species Thermus thermophilus [TaxId:274] [117409] (1 PDB entry)
      Uniprot Q5SLI9
  32. 2427336Erythromycin synthase, eryAI, 1st ketoreductase module [141909] (1 species)
    tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
  33. 2427342GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  34. 2427352GDP-mannose 4,6-dehydratase [51759] (4 species)
    1. 2427353Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 2427355Species Human (Homo sapiens) [TaxId:9606] [102135] (3 PDB entries)
    3. 2427368Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
    4. 2427373Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  35. 2427380GDP-mannose-3', 5'-epimerase [141890] (1 species)
  36. 2427386Gluconate 5-dehydrogenase [110411] (1 species)
  37. 2427390Glucose dehydrogenase [51784] (1 species)
  38. 2427408Glucose dehydrogenase (5l265) [102155] (1 species)
  39. 2427411Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
  40. 2427443Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  41. 2427475Hypothetical protein At5g02240 (T7H20_290) [117417] (1 species)
  42. 2427485Hypothetical protein F25D1.5 [110415] (1 species)
  43. 2427489Hypothetical protein PA4017 [141911] (1 species)
    unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
  44. 2427493Hypothetical protein R05D8.7 [117415] (1 species)
  45. 2427499Hypothetical protein TTHA0369 [141896] (1 species)
    TT0321
  46. 2427502Levodione reductase [89523] (1 species)
  47. 2427512Mannitol dehydrogenase [63927] (1 species)
  48. 2427526meso-2,3-butanediol dehydrogenase [51786] (1 species)
  49. 2427536Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  50. 2427545Peroxisomal multifunctional enzyme type 2 [141900] (1 species)
    17-beta-hydroxysteroid dehydrogenase 4
  51. 2427553Peroxisomal trans 2-enoyl CoA reductase [141884] (1 species)
  52. 2427559Phenylcoumaran benzylic ether reductase [102140] (1 species)
  53. 2427563Pinoresinol-lariciresinol reductase [102142] (1 species)
  54. 2427569Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
  55. 2427587Putative carbonyl reductase sniffer [141913] (1 species)
  56. 2427590Putative dehydrogenase ARPG836 (MGC4172) [117411] (1 species)
  57. 2427596Putative oxidoreductase Rv2002 [82292] (1 species)
  58. 2427608R-specific alcohol dehydrogenase [89521] (1 species)
  59. 2427612Retinal dehydrogenase/reductase 3 [141907] (1 species)
  60. 2427615Rhizome secoisolariciresinol dehydrogenase [141898] (1 species)
  61. 2427618Sepiapterin reductase [51767] (2 species)
    1. 2427619Species Human (Homo sapiens) [TaxId:9606] [141874] (6 PDB entries)
      Uniprot P35270 5-261
    2. 2427646Species Mouse (Mus musculus) [TaxId:10090] [51768] (3 PDB entries)
  62. 2427650Sorbitol dehydrogenase [102148] (1 species)
  63. 2427654Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  64. 2427660TAT-interacting protein TIP30 [141904] (2 species)
    1. 2427661Species Human (Homo sapiens) [TaxId:9606] [141905] (1 PDB entry)
      Uniprot Q9BUP3 5-236
    2. 2427663Species Mouse (Mus musculus) [TaxId:10090] [141906] (1 PDB entry)
      Uniprot Q9Z2G9 7-236
  65. 2427665Tropinone reductase [51795] (3 species)
    1. 2427666Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 2427669Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
    3. 2427677Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117410] (1 PDB entry)
      Uniprot Q9ASX2
  66. 2427679Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)
    1. 2427680Species Human (Homo sapiens) [TaxId:9606] [102152] (2 PDB entries)
      Uniprot Q99714
    2. 2427686Species Norway rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    3. 2427699Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  67. 2427702UDP-glucuronate decarboxylase 1 [141880] (1 species)
  68. 2427705UDP-N-acetylglucosamine 4-epimerase WbpP [110407] (1 species)
  69. 2427709Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)
    1. 2427710Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [141872] (1 PDB entry)
      Uniprot P04397 11-357
      N-terminal domain of bifunctional Gal10 protein
    2. 2427712Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    3. 2427731Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    4. 2427745Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [89519] (1 PDB entry)
  70. 2427750Xylitol dehydrogenase [141882] (1 species)
  71. 2427753automated matches [190085] (51 species)
    not a true protein
    1. 2427754Species Acinetobacter baumannii [TaxId:470] [272807] (1 PDB entry)
    2. 2427756Species Alcaligenes faecalis [TaxId:511] [188427] (11 PDB entries)
    3. 2427787Species Alfalfa (Medicago sativa) [TaxId:3879] [187740] (1 PDB entry)
    4. 2427790Species Aquifex aeolicus [TaxId:224324] [188271] (2 PDB entries)
    5. 2427799Species Bacillus anthracis [TaxId:198094] [188031] (1 PDB entry)
    6. 2427808Species Bacillus megaterium [TaxId:1404] [195340] (5 PDB entries)
    7. 2427821Species Burkholderia pseudomallei [TaxId:272560] [279838] (11 PDB entries)
    8. 2427862Species Burkholderia pseudomallei [TaxId:28450] [330011] (1 PDB entry)
    9. 2427864Species Burkholderia pseudomallei [TaxId:320372] [188614] (3 PDB entries)
    10. 2427876Species Burkholderia pseudomallei [TaxId:884204] [238338] (1 PDB entry)
    11. 2427878Species Chlamydia trachomatis [TaxId:1340853] [257638] (1 PDB entry)
    12. 2427887Species Comamonas testosteroni [TaxId:285] [189779] (3 PDB entries)
    13. 2427894Species Daffodil (Narcissus pseudonarcissus) [TaxId:39639] [318114] (2 PDB entries)
    14. 2427901Species Eimeria tenella [TaxId:413949] [187997] (1 PDB entry)
    15. 2427904Species Emericella nidulans [TaxId:162425] [187249] (3 PDB entries)
    16. 2427929Species Escherichia coli K-12 [TaxId:83333] [189924] (3 PDB entries)
    17. 2427936Species Escherichia coli [TaxId:469008] [256724] (3 PDB entries)
    18. 2427943Species Escherichia coli [TaxId:562] [255679] (2 PDB entries)
    19. 2427974Species Escherichia coli [TaxId:83333] [326678] (1 PDB entry)
    20. 2427977Species Francisella tularensis [TaxId:177416] [189289] (1 PDB entry)
    21. 2427982Species Francisella tularensis [TaxId:263] [188795] (1 PDB entry)
    22. 2427987Species Human (Homo sapiens) [TaxId:9606] [186828] (23 PDB entries)
    23. 2428057Species Klebsiella pneumoniae [TaxId:573] [276380] (1 PDB entry)
    24. 2428060Species Lactobacillus brevis [TaxId:1580] [186912] (6 PDB entries)
    25. 2428074Species Leishmania donovani [TaxId:5661] [189607] (1 PDB entry)
    26. 2428077Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [186807] (1 PDB entry)
    27. 2428079Species Mycobacterium tuberculosis [TaxId:83332] [229356] (1 PDB entry)
    28. 2428086Species Naegleria fowleri [TaxId:5763] [332799] (1 PDB entry)
    29. 2428088Species Neisseria meningitidis [TaxId:272831] [228105] (3 PDB entries)
    30. 2428095Species Pandoraea pnomenusa [TaxId:93220] [189780] (3 PDB entries)
    31. 2428102Species Plasmodium berghei [TaxId:5821] [189246] (1 PDB entry)
    32. 2428107Species Plasmodium falciparum [TaxId:36329] [228763] (2 PDB entries)
    33. 2428112Species Plesiomonas shigelloides [TaxId:703] [189972] (9 PDB entries)
    34. 2428147Species Pseudomonas aeruginosa, PA01 [TaxId:208964] [261223] (2 PDB entries)
    35. 2428168Species Pseudomonas fragi [TaxId:296] [188080] (6 PDB entries)
    36. 2428187Species Pseudomonas putida [TaxId:303] [188252] (3 PDB entries)
    37. 2428204Species Rhizobium radiobacter [TaxId:358] [197100] (3 PDB entries)
    38. 2428211Species Sinorhizobium meliloti [TaxId:266834] [195628] (1 PDB entry)
    39. 2428216Species Staphylococcus aureus [TaxId:282458] [193773] (1 PDB entry)
    40. 2428218Species Streptomyces coelicolor [TaxId:1902] [189970] (5 PDB entries)
    41. 2428229Species Streptomyces griseoruber [TaxId:1943] [196180] (1 PDB entry)
    42. 2428232Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [187183] (5 PDB entries)
    43. 2428238Species Thermus thermophilus HB8 [TaxId:300852] [187188] (4 PDB entries)
    44. 2428259Species Thermus thermophilus [TaxId:274] [187600] (1 PDB entry)
    45. 2428263Species Toxoplasma gondii [TaxId:383379] [187942] (3 PDB entries)
    46. 2428274Species Toxoplasma gondii [TaxId:5811] [261808] (1 PDB entry)
    47. 2428277Species Trypanosoma brucei [TaxId:5702] [187520] (4 PDB entries)
    48. 2428294Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [187036] (1 PDB entry)
    49. 2428299Species Vibrio cholerae [TaxId:243277] [189479] (8 PDB entries)
    50. 2428314Species Vibrio cholerae [TaxId:593588] [189768] (3 PDB entries)
    51. 2428325Species Yersinia pestis [TaxId:632] [279426] (2 PDB entries)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: