SCOPe 2.08: Domain d2bf7d_: 2bf7 D:

Lineage for d2bf7d_ (2bf7 D:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)

7. Species Leishmania major [TaxId:5664] [63926] (14 PDB entries)
   Uniprot Q01782

8. Domain d2bf7d_: 2bf7 D: [128410]
   automated match to d1e7wa_
   complexed with edo, hbi, nap

Details for d2bf7d_

PDB Entry: 2bf7, 2.4 Å

PDB Description: leishmania major pteridine reductase 1 in complex with nadp and biopterin

PDB Compounds: (D:) pteridine reductase 1

SCOPe Domain Sequences for d2bf7d_:

Sequence, based on SEQRES records:

>d2bf7d_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrnded
ghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamt
nqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweghrsk
vplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

Sequence, based on observed residues (ATOM records):

>d2bf7d_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatappvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatadlf
gsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgalegl
trsaalelaplqirvngvgpglsvlvrskvplyqrdssaaevsdvviflcsskakyitgt
cvkvdggysltra

Timeline for d2bf7d_:

• d2bf7d_ first appeared in SCOP 1.73, called d2bf7d1
  
• d2bf7d_ appears in SCOPe 2.07