Lineage for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2841004Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2841005Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)

Families:

  1. 2841006c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (19 proteins)
    N-terminal all-beta domain defines family
  2. 2841375c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

    has additional subdomain(s) that are not in the common domain
  3. 2843543c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (22 proteins)
    family members also share a common alpha+beta fold in C-terminal domain
  4. 2844156c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain [51830] (10 proteins)
    this domain interrupts the other domain which defines family
  5. 2844315c.2.1.5: LDH N-terminal domain-like [51848] (9 proteins)
  6. 2844998c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (19 proteins)
    the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
    C-terminal domains also show some similarity
  7. 2845190c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
  8. 2845549c.2.1.8: CoA-binding domain [51900] (6 proteins)
  9. 2845624c.2.1.9: Potassium channel NAD-binding domain [63944] (5 proteins)
    automatically mapped to Pfam PF02254
  10. 2845736c.2.1.11: Siroheme synthase N-terminal domain-like [75110] (2 proteins)
  11. 2845757c.2.1.12: Transcriptional repressor Rex, C-terminal domain [102174] (2 proteins)
    automatically mapped to Pfam PF02629
  12. 2845780c.2.1.13: Ornithine cyclodeaminase-like [110436] (2 proteins)
    Pfam PF02423; contains additional alpha+beta dimerisation subdomain mostly formed by the N-terminal meander beta-sheet
  13. 2845793c.2.1.0: automated matches [191313] (1 protein)
    not a true family

More info for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains

Timeline for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains: