SCOPe 2.08: Species: Leishmania major [TaxId: 5664]

Lineage for Species: Leishmania major [TaxId: 5664]

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
has additional subdomain(s) that are not in the common domain

Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)
Species Leishmania major [TaxId:5664] [63926] (14 PDB entries)
Uniprot Q01782

PDB entries in Species: Leishmania major [TaxId: 5664]:

Domain(s) for 1e7w:
1. Domain d1e7wa_: 1e7w A: [59373]
  complexed with edo, mtx, ndp
2. Domain d1e7wb_: 1e7w B: [59374]
  complexed with edo, mtx, ndp
Domain(s) for 1e92:
1. Domain d1e92a_: 1e92 A: [64798]
  complexed with edo, hbi, nap
2. Domain d1e92b_: 1e92 B: [64799]
  complexed with edo, hbi, nap
3. Domain d1e92c_: 1e92 C: [64800]
  complexed with edo, hbi, nap
4. Domain d1e92d_: 1e92 D: [64801]
  complexed with edo, hbi, nap
Domain(s) for 1w0c:
1. Domain d1w0ca_: 1w0c A: [114052]
  complexed with nap, taq
2. Domain d1w0cb_: 1w0c B: [114053]
  complexed with nap, taq
3. Domain d1w0cc_: 1w0c C: [114054]
  complexed with nap, taq
4. Domain d1w0cd_: 1w0c D: [114055]
  complexed with nap, taq
5. Domain d1w0ce_: 1w0c E: [114056]
  complexed with nap, taq
6. Domain d1w0cf_: 1w0c F: [114057]
  complexed with nap, taq
7. Domain d1w0cg_: 1w0c G: [114058]
  complexed with nap, taq
8. Domain d1w0ch_: 1w0c H: [114059]
  complexed with nap, taq
Domain(s) for 2bf7:
1. Domain d2bf7a_: 2bf7 A: [128407]
  automated match to d1e7wa_
  complexed with edo, hbi, nap
2. Domain d2bf7b_: 2bf7 B: [128408]
  automated match to d1e7wa_
  complexed with edo, hbi, nap
3. Domain d2bf7c_: 2bf7 C: [128409]
  automated match to d1e7wa_
  complexed with edo, hbi, nap
4. Domain d2bf7d_: 2bf7 D: [128410]
  automated match to d1e7wa_
  complexed with edo, hbi, nap
Domain(s) for 2bfa:
1. Domain d2bfaa_: 2bfa A: [128413]
  automated match to d1e7wa_
  complexed with cb3, edo, ndp
2. Domain d2bfab_: 2bfa B: [128414]
  automated match to d1e7wa_
  complexed with cb3, edo, ndp
3. Domain d2bfac_: 2bfa C: [128415]
  automated match to d1e7wa_
  complexed with cb3, edo, ndp
4. Domain d2bfad_: 2bfa D: [128416]
  automated match to d1e7wa_
  complexed with cb3, edo, ndp
Domain(s) for 2bfm:
1. Domain d2bfma_: 2bfm A: [128439]
  automated match to d1e7wa_
  complexed with ndp, top
2. Domain d2bfmb_: 2bfm B: [128440]
  automated match to d1e7wa_
  complexed with ndp, top
3. Domain d2bfmc_: 2bfm C: [128441]
  automated match to d1e7wa_
  complexed with ndp, top
4. Domain d2bfmd_: 2bfm D: [128442]
  automated match to d1e7wa_
  complexed with ndp, top
Domain(s) for 2bfo:
1. Domain d2bfoa_: 2bfo A: [128444]
  automated match to d1e7wa_
  complexed with edo, ndp
2. Domain d2bfob_: 2bfo B: [128445]
  automated match to d1e7wa_
  complexed with edo, ndp
3. Domain d2bfoc_: 2bfo C: [128446]
  automated match to d1e7wa_
  complexed with edo, ndp
4. Domain d2bfod_: 2bfo D: [128447]
  automated match to d1e7wa_
  complexed with edo, ndp
Domain(s) for 2bfp:
1. Domain d2bfpa_: 2bfp A: [128448]
  automated match to d1e7wa_
  complexed with edo, h4b, nap
2. Domain d2bfpb_: 2bfp B: [128449]
  automated match to d1e7wa_
  complexed with edo, h4b, nap
3. Domain d2bfpc_: 2bfp C: [128450]
  automated match to d1e7wa_
  complexed with edo, h4b, nap
4. Domain d2bfpd_: 2bfp D: [128451]
  automated match to d1e7wa_
  complexed with edo, h4b, nap
Domain(s) for 2p8k:
1. Domain d2p8ka_: 2p8k A: [304331]
  automated match to d1e92b_
  complexed with dyp, nap
2. Domain d2p8kb_: 2p8k B: [304332]
  automated match to d1e92b_
  complexed with dyp, nap
3. Domain d2p8kc_: 2p8k C: [304333]
  automated match to d1e92a_
  complexed with dyp, nap
4. Domain d2p8kd_: 2p8k D: [304334]
  automated match to d1e92b_
  complexed with dyp, nap
5. Domain d2p8ke_: 2p8k E: [304335]
  automated match to d1e92a_
  complexed with dyp, nap
6. Domain d2p8kf_: 2p8k F: [304336]
  automated match to d1e92b_
  complexed with dyp, nap
7. Domain d2p8kg_: 2p8k G: [304337]
  automated match to d1e92a_
  complexed with dyp, nap
8. Domain d2p8kh_: 2p8k H: [304338]
  automated match to d1e92b_
  complexed with dyp, nap
Domain(s) for 2qhx:
1. Domain d2qhxa1: 2qhx A:5-288 [150796]
  Other proteins in same PDB: d2qhxc_
  automatically matched to d1e7wa_
  complexed with fe1, iod, nap
2. Domain d2qhxb_: 2qhx B: [150797]
  Other proteins in same PDB: d2qhxc_
  automated match to d1p33b_
  complexed with fe1, iod, nap
3. Domain d2qhxd_: 2qhx D: [150799]
  Other proteins in same PDB: d2qhxc_
  automated match to d1p33b_
  complexed with fe1, iod, nap
Domain(s) for 3h4v:
1. Domain d3h4va_: 3h4v A: [177181]
  automated match to d1e7wa_
  complexed with dvp, nap
2. Domain d3h4vb_: 3h4v B: [177182]
  automated match to d1e7wa_
  complexed with dvp, nap
3. Domain d3h4vc_: 3h4v C: [177183]
  automated match to d1e7wa_
  complexed with dvp, nap
4. Domain d3h4vd_: 3h4v D: [177184]
  automated match to d1e7wa_
  complexed with dvp, nap
5. Domain d3h4ve_: 3h4v E: [177185]
  automated match to d1e7wa_
  complexed with dvp, nap
6. Domain d3h4vf_: 3h4v F: [177186]
  automated match to d1e7wa_
  complexed with dvp, nap
7. Domain d3h4vg_: 3h4v G: [177187]
  automated match to d1e7wa_
  complexed with dvp, nap
8. Domain d3h4vh_: 3h4v H: [177188]
  automated match to d1e7wa_
  complexed with dvp, nap
Domain(s) for 5l42:
1. Domain d5l42a_: 5l42 A: [339580]
  automated match to d1e92b_
  complexed with 6j6, act, edo, gol, ndp, pge
2. Domain d5l42b_: 5l42 B: [339538]
  automated match to d1e92b_
  complexed with 6j6, act, edo, gol, ndp, pge
3. Domain d5l42c_: 5l42 C: [339555]
  automated match to d1e92b_
  complexed with 6j6, act, edo, gol, ndp, pge
4. Domain d5l42d_: 5l42 D: [339552]
  automated match to d1e92b_
  complexed with 6j6, act, edo, gol, ndp, pge
Domain(s) for 5l4n:
1. Domain d5l4na_: 5l4n A: [331675]
  automated match to d1e92b_
  complexed with 6qt, act, edo, gol, ndp, peg, pge
2. Domain d5l4nb_: 5l4n B: [331667]
  automated match to d1e92b_
  complexed with 6qt, act, edo, gol, ndp, peg, pge
3. Domain d5l4nc_: 5l4n C: [331681]
  automated match to d1e92b_
  complexed with 6qt, act, edo, gol, ndp, peg, pge
4. Domain d5l4nd_: 5l4n D: [331672]
  automated match to d1e92b_
  complexed with 6qt, act, edo, gol, ndp, peg, pge
Domain(s) for 6rxc:
1. Domain d6rxca_: 6rxc A: [389363]
  automated match to d1e7wa_
  complexed with kmk, ndp
2. Domain d6rxcb_: 6rxc B: [389394]
  automated match to d1e7wa_
  complexed with kmk, ndp
3. Domain d6rxcc_: 6rxc C: [389417]
  automated match to d1e7wa_
  complexed with kmk, ndp
4. Domain d6rxcd_: 6rxc D: [389349]
  automated match to d1e7wa_
  complexed with kmk, ndp

More info for Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase)

Timeline for Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase):

Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase) first appeared in SCOP 1.57
Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase) appears in SCOPe 2.07