SCOPe 2.08: Domain d6gd0a_: 6gd0 A:

Lineage for d6gd0a_ (6gd0 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)

7. Species Trypanosoma brucei [TaxId:5702] [226783] (32 PDB entries)

8. Domain d6gd0a_: 6gd0 A: [367077]
   automated match to d3bmob_
   complexed with act, ev8, nap

Details for d6gd0a_

PDB Entry: 6gd0, 1.74 Å

PDB Description: trypanosoma brucei ptr1 in complex with inhibitor 4g (f133)

PDB Compounds: (A:) pteridine reductase

SCOPe Domain Sequences for d6gd0a_:

Sequence, based on SEQRES records:

>d6gd0a_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqva
eligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkhal
vgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadav
iflvsgsaqyitgsiikvdgglslvha

Sequence, based on observed residues (ATOM records):

>d6gd0a_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgktvetqvaeligtnai
apflltmsfaqrqkctssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelap
ygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitg
siikvdgglslvha

Timeline for d6gd0a_:

• d6gd0a_ first appeared in SCOPe 2.07