PDB entry 1e92

View 1e92 on RCSB PDB site
Description: Pteridine reductase 1 from Leishmania major complexed with NADP+ and dihydrobiopterin
Class: pteridine reductase
Keywords: pteridine reductase, trypanosomatids, drug resistance, pterin salvage, short-chain dehydrogenase/reductase
Deposited on 2000-10-04, released 2001-10-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-06, with a file datestamp of 2019-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pteridine reductase 1
    Species: Leishmania major [TaxId:5664]
    Gene: PTR1
    Database cross-references and differences (RAF-indexed):
    • TREMBL Q9U1F8 (Start-287)
    Domains in SCOPe 2.08: d1e92a_
  • Chain 'B':
    Compound: pteridine reductase 1
    Species: Leishmania major [TaxId:5664]
    Gene: PTR1
    Database cross-references and differences (RAF-indexed):
    • TREMBL Q9U1F8 (Start-287)
    Domains in SCOPe 2.08: d1e92b_
  • Chain 'C':
    Compound: pteridine reductase 1
    Species: Leishmania major [TaxId:5664]
    Gene: PTR1
    Database cross-references and differences (RAF-indexed):
    • TREMBL Q9U1F8 (Start-287)
    Domains in SCOPe 2.08: d1e92c_
  • Chain 'D':
    Compound: pteridine reductase 1
    Species: Leishmania major [TaxId:5664]
    Gene: PTR1
    Database cross-references and differences (RAF-indexed):
    • TREMBL Q9U1F8 (Start-287)
    Domains in SCOPe 2.08: d1e92d_
  • Heterogens: NAP, HBI, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1e92A (A:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >1e92A (A:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrndgdreametat
adlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakga
legltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdv
viflcsskakyitgtcvkvdggysltra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1e92B (B:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >1e92B (B:)
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatad
lfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgale
gltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdvvi
flcsskakyitgtcvkvdggysltra

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1e92C (C:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >1e92C (C:)
vpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqad
lsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrndreametatad
lfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgale
gltrsaalelaplqirvngvgpglsvlvghrskvplyqrdssaaevsdvviflcsskaky
itgtcvkvdggysltra

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1e92D (D:)
mtaptvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsai
tvqadlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllr
ndedghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmv
damtnqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweg
hrskvplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

    Sequence, based on observed residues (ATOM records): (download) 
    >1e92D (D:)
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrreametatadl
fgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgaleg
ltrsaalelaplqirvngvgpglsvlvghrskvplyqrdssaaevsdvviflcsskakyi
tgtcvkvdggysltra