Lineage for Protein: Interferon-alpha 2a

  1. Root: SCOPe 2.08
  2. 2685877Class a: All alpha proteins [46456] (290 folds)
  3. 2705447Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 2705448Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 2705784Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins)
    contains an additional helix in one of the crossover connections
  6. 2705785Protein Interferon-alpha 2a [47314] (2 species)

Species:

  1. 2705786Human (Homo sapiens) [TaxId:9606] [47315] (9 PDB entries)
    1. Domain for 1itf:
    2. Domain for 2hym:
    3. Domain for 2ksx:
    4. Domain for 2kz1:
    5. Domain for 2lag:
    6. Domain for 2lms:
    7. Domains for 3s9d:
      1. 2705787Domain d3s9da_: 3s9d A: [200600]
        Other proteins in same PDB: d3s9db1, d3s9db2, d3s9dd1, d3s9dd2
        automated match to d3s9dc_
        complexed with cl
      2. 2705788Domain d3s9dc_: 3s9d C: [196189]
        Other proteins in same PDB: d3s9db1, d3s9db2, d3s9dd1, d3s9dd2
        automated match to d1itfa_
        complexed with cl
    8. Domains for 4ypg:
      1. 2705797Domain d4ypgc1: 4ypg C:1-157 [272489]
        Other proteins in same PDB: d4ypga1, d4ypga2, d4ypgb_, d4ypgc2, d4ypgd2, d4ypgh_, d4ypgl1, d4ypgl2
        automated match to d1itfa_
        complexed with ni
      2. 2705798Domain d4ypgd1: 4ypg D:1-159 [272488]
        Other proteins in same PDB: d4ypga1, d4ypga2, d4ypgb_, d4ypgc2, d4ypgd2, d4ypgh_, d4ypgl1, d4ypgl2
        automated match to d1itfa_
        complexed with ni
    9. Domains for 4z5r:
      1. 2705789Domain d4z5rd_: 4z5r D: [274819]
        Other proteins in same PDB: d4z5ra1, d4z5ra2, d4z5rb_, d4z5rj1, d4z5rj2, d4z5rk_, d4z5rl1, d4z5rl2, d4z5rm_, d4z5rp1, d4z5rp2, d4z5rq_, d4z5rr1, d4z5rr2, d4z5rs_, d4z5rt1, d4z5rt2, d4z5ru_, d4z5rv1, d4z5rv2, d4z5rw_, d4z5ry_, d4z5rz_
        automated match to d1itfa_
        complexed with so4
      2. 2705790Domain d4z5re_: 4z5r E: [274818]
        Other proteins in same PDB: d4z5ra1, d4z5ra2, d4z5rb_, d4z5rj1, d4z5rj2, d4z5rk_, d4z5rl1, d4z5rl2, d4z5rm_, d4z5rp1, d4z5rp2, d4z5rq_, d4z5rr1, d4z5rr2, d4z5rs_, d4z5rt1, d4z5rt2, d4z5ru_, d4z5rv1, d4z5rv2, d4z5rw_, d4z5ry_, d4z5rz_
        automated match to d1itfa_
        complexed with so4
      3. 2705791Domain d4z5rf_: 4z5r F: [274816]
        Other proteins in same PDB: d4z5ra1, d4z5ra2, d4z5rb_, d4z5rj1, d4z5rj2, d4z5rk_, d4z5rl1, d4z5rl2, d4z5rm_, d4z5rp1, d4z5rp2, d4z5rq_, d4z5rr1, d4z5rr2, d4z5rs_, d4z5rt1, d4z5rt2, d4z5ru_, d4z5rv1, d4z5rv2, d4z5rw_, d4z5ry_, d4z5rz_
        automated match to d1itfa_
        complexed with so4
      4. 2705792Domain d4z5rg_: 4z5r G: [274817]
        Other proteins in same PDB: d4z5ra1, d4z5ra2, d4z5rb_, d4z5rj1, d4z5rj2, d4z5rk_, d4z5rl1, d4z5rl2, d4z5rm_, d4z5rp1, d4z5rp2, d4z5rq_, d4z5rr1, d4z5rr2, d4z5rs_, d4z5rt1, d4z5rt2, d4z5ru_, d4z5rv1, d4z5rv2, d4z5rw_, d4z5ry_, d4z5rz_
        automated match to d1itfa_
        complexed with so4
      5. 2705793Domain d4z5rh_: 4z5r H: [274820]
        Other proteins in same PDB: d4z5ra1, d4z5ra2, d4z5rb_, d4z5rj1, d4z5rj2, d4z5rk_, d4z5rl1, d4z5rl2, d4z5rm_, d4z5rp1, d4z5rp2, d4z5rq_, d4z5rr1, d4z5rr2, d4z5rs_, d4z5rt1, d4z5rt2, d4z5ru_, d4z5rv1, d4z5rv2, d4z5rw_, d4z5ry_, d4z5rz_
        automated match to d1itfa_
        complexed with so4
      6. 2705794Domain d4z5ri_: 4z5r I: [274821]
        Other proteins in same PDB: d4z5ra1, d4z5ra2, d4z5rb_, d4z5rj1, d4z5rj2, d4z5rk_, d4z5rl1, d4z5rl2, d4z5rm_, d4z5rp1, d4z5rp2, d4z5rq_, d4z5rr1, d4z5rr2, d4z5rs_, d4z5rt1, d4z5rt2, d4z5ru_, d4z5rv1, d4z5rv2, d4z5rw_, d4z5ry_, d4z5rz_
        automated match to d1itfa_
        complexed with so4
      7. 2705795Domain d4z5rn_: 4z5r N: [274822]
        Other proteins in same PDB: d4z5ra1, d4z5ra2, d4z5rb_, d4z5rj1, d4z5rj2, d4z5rk_, d4z5rl1, d4z5rl2, d4z5rm_, d4z5rp1, d4z5rp2, d4z5rq_, d4z5rr1, d4z5rr2, d4z5rs_, d4z5rt1, d4z5rt2, d4z5ru_, d4z5rv1, d4z5rv2, d4z5rw_, d4z5ry_, d4z5rz_
        automated match to d1itfa_
        complexed with so4
      8. 2705796Domain d4z5rx_: 4z5r X: [274831]
        Other proteins in same PDB: d4z5ra1, d4z5ra2, d4z5rb_, d4z5rj1, d4z5rj2, d4z5rk_, d4z5rl1, d4z5rl2, d4z5rm_, d4z5rp1, d4z5rp2, d4z5rq_, d4z5rr1, d4z5rr2, d4z5rs_, d4z5rt1, d4z5rt2, d4z5ru_, d4z5rv1, d4z5rv2, d4z5rw_, d4z5ry_, d4z5rz_
        automated match to d1itfa_
        complexed with so4
  2. 2705805Mouse (Mus musculus) [TaxId:10090] [419764] (1 PDB entry)

More info for Protein Interferon-alpha 2a from a.26.1.3: Interferons/interleukin-10 (IL-10)

Timeline for Protein Interferon-alpha 2a from a.26.1.3: Interferons/interleukin-10 (IL-10):