Lineage for Family a.26.1.3: Interferons/interleukin-10 (IL-10)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991729Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 protein domains)
    contains an additional helix in one of the crossover connections

Protein Domains:

  1. 1991730Interferon-alpha 2a [47314] (1 species)
  2. 1991750Interferon-alpha 2b [47312] (1 species)
  3. 1991758Interferon-beta [47309] (2 species)
    1. 1991759Species Human (Homo sapiens) [TaxId:9606] [47310] (1 PDB entry)
    2. 1991762Species Mouse (Mus musculus) [TaxId:10090] [47311] (4 PDB entries)
      Uniprot P01575 22-182
      CA-atoms only
  4. 1991767Interferon-gamma [47318] (3 species)
    intertwined dimer
    1. 1991768Species Cow (Bos taurus) [TaxId:9913] [47319] (3 PDB entries)
    2. 1991775Species Human (Homo sapiens) [TaxId:9606] [47320] (4 PDB entries)
    3. 1991790Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47321] (1 PDB entry)
  5. 1991792Interferon-tau [47316] (1 species)
  6. 1991795Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
    intertwined dimer, similar to interferon-gamma
    1. 1991796Species Epstein-Barr virus [TaxId:10376] [47308] (3 PDB entries)
    2. 1991800Species Human (Homo sapiens) [TaxId:9606] [47307] (6 PDB entries)
    3. 1991808Species Human herpesvirus 5 [TaxId:10359] [74708] (1 PDB entry)
  7. 1991811Interleukin-19 [81744] (1 species)
  8. 1991814Interleukin-22 (IL-22) [89036] (1 species)
  9. 1991828automated matches [190141] (2 species)
    not a true protein
    1. 1991829Species Human (Homo sapiens) [TaxId:9606] [187124] (4 PDB entries)
    2. 1991836Species Mouse (Mus musculus) [TaxId:10090] [189956] (2 PDB entries)

More info for Family a.26.1.3: Interferons/interleukin-10 (IL-10)

Timeline for Family a.26.1.3: Interferons/interleukin-10 (IL-10):