Lineage for Superfamily a.26.1: 4-helical cytokines

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections

Families:

  1. 1991438a.26.1.1: Long-chain cytokines [47267] (10 protein domains)
  2. 1991528a.26.1.2: Short-chain cytokines [47286] (14 protein domains)
  3. 1991729a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 protein domains)
    contains an additional helix in one of the crossover connections
  4. 1991840a.26.1.0: automated matches [194949] (1 protein)
    not a true family

More info for Superfamily a.26.1: 4-helical cytokines

Timeline for Superfamily a.26.1: 4-helical cytokines: