SCOPe 2.08: Family a.26.1.1: Long-chain cytokines

Lineage for Family a.26.1.1: Long-chain cytokines

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)

Proteins:

1. Ciliary neurotrophic factor (CNTF) [47280] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47281] (1 PDB entry)

2. Granulocyte-colony stimulating factor (G-CSF) [47268] (3 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [47270] (1 PDB entry)

   2. Species Dog (Canis familiaris) [TaxId:9615] [47271] (2 PDB entries)

   3. Species Human (Homo sapiens) [TaxId:9606] [47269] (4 PDB entries)

3. Growth hormone, somatotropin [47276] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47277] (9 PDB entries)

4. Heterodimeric interleukin-12 alpha chain [63530] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [63531] (1 PDB entry)

5. Interleukin-6 [47272] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [47273] (9 PDB entries)

   2. Species Human herpesvirus 8, Kaposi's sarcoma herpes-virus [TaxId:37296] [63528] (1 PDB entry)

6. Leptin (obesity protein) [47282] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47283] (1 PDB entry)

7. Leukemia inhibitory factor (LIF) [47274] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [63529] (3 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [47275] (2 PDB entries)

8. Oncostatin M [47284] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47285] (1 PDB entry)

9. Prolactin (placental lactogen) [47278] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [89035] (4 PDB entries)

   2. Species Sheep (Ovis aries) [TaxId:9940] [47279] (1 PDB entry)

10. automated matches [190263] (1 species)
    not a true protein

    • Species Human (Homo sapiens) [TaxId:9606] [187052] (14 PDB entries)

More info for Family a.26.1.1: Long-chain cytokines

Timeline for Family a.26.1.1: Long-chain cytokines:

• Family a.26.1.1: Long-chain cytokines first appeared (with stable ids) in SCOP 1.55
  
• Family a.26.1.1: Long-chain cytokines appears in SCOPe 2.07