Lineage for Family a.26.1.2: Short-chain cytokines

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2315782Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 2315783Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 2315881Family a.26.1.2: Short-chain cytokines [47286] (14 protein domains)

Protein Domains:

  1. 2315882Erythropoietin [47287] (1 species)
    long chain cytokine with a short-chain cytokine topology
  2. 2315887Flt3 ligand [47297] (1 species)
    forms dimer similar to the M-CSF and SCF dimers
  3. 2315893Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289] (1 species)
  4. 2315907Interleukin-13 (IL-13) [63532] (1 species)
  5. 2315924Interleukin-15 (IL-15) [158422] (2 species)
    1. 2315925Species Human (Homo sapiens) [TaxId:9606] [158423] (3 PDB entries)
      Uniprot P40933 49-162
    2. 2315937Species Mouse (Mus musculus) [TaxId:10090] [158424] (1 PDB entry)
      Uniprot P48346 49-162
  6. 2315940Interleukin-2 (IL-2) [47301] (1 species)
  7. 2315977Interleukin-21 (IL-21) [158425] (1 species)
  8. 2315988Interleukin-3 (IL-3) [47303] (1 species)
  9. 2315991Interleukin-4 (IL-4) [47291] (1 species)
  10. 2316010Interleukin-5 [47293] (1 species)
    intertwined dimer
  11. 2316014Macrophage colony-stimulating factor (M-CSF) [47295] (1 species)
    forms dimer similar to the Flt3 ligand and SCF dimers
  12. 2316018Stem cell factor, SCF [47299] (1 species)
    forms dimer similar to the M-CSF and Flt3 ligand dimers
  13. 2316029Thrombopoietin [101140] (1 species)
    long chain cytokine with a short-chain cytokine topology
  14. 2316037automated matches [190501] (4 species)
    not a true protein
    1. 2316038Species Human (Homo sapiens) [TaxId:9606] [187448] (20 PDB entries)
    2. 2316074Species Mouse (Mus musculus) [TaxId:10090] [187941] (5 PDB entries)
    3. 2316087Species Mustela putorius [TaxId:9669] [279075] (1 PDB entry)
    4. 2316090Species Sheep (Ovis aries) [TaxId:9940] [326182] (2 PDB entries)

More info for Family a.26.1.2: Short-chain cytokines

Timeline for Family a.26.1.2: Short-chain cytokines: