Lineage for Protein: Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2136823Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

Species:

  1. 2136824Cryptosporidium hominis [TaxId:237895] [102636] (3 PDB entries)
    Uniprot Q5CGA3 Q27552
    1. Domains for 1qzf:
      1. 2136825Domain d1qzfa1: 1qzf A:3-180 [96633]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
      2. 2136826Domain d1qzfb1: 1qzf B:3-180 [96635]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
      3. 2136827Domain d1qzfc1: 1qzf C:3-180 [96637]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
      4. 2136828Domain d1qzfd1: 1qzf D:3-180 [96639]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
      5. 2136829Domain d1qzfe1: 1qzf E:3-180 [96641]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
    2. Domains for 1sej:
      1. 2136830Domain d1seja1: 1sej A:3-180 [105455]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
      2. 2136831Domain d1sejb1: 1sej B:3-180 [105457]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
      3. 2136832Domain d1sejc1: 1sej C:3-180 [105459]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
      4. 2136833Domain d1sejd1: 1sej D:3-180 [105461]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
      5. 2136834Domain d1seje1: 1sej E:3-180 [105463]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
    3. Domains for 4q0e:
      1. 2136835Domain d4q0ea1: 4q0e A:3-178 [260370]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
      2. 2136836Domain d4q0eb1: 4q0e B:3-178 [260368]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
      3. 2136837Domain d4q0ec1: 4q0e C:3-178 [260372]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
      4. 2136838Domain d4q0ed1: 4q0e D:3-178 [260376]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
      5. 2136839Domain d4q0ee1: 4q0e E:3-178 [260374]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
  2. 2136840Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)
    1. Domains for 1j3i:
      1. 2136843Domain d1j3ia_: 1j3i A: [84062]
        Other proteins in same PDB: d1j3ic_, d1j3id_
        complexed with ndp, ump, wra
      2. 2136844Domain d1j3ib_: 1j3i B: [84063]
        Other proteins in same PDB: d1j3ic_, d1j3id_
        complexed with ndp, ump, wra
    2. Domains for 1j3j:
      1. 2136845Domain d1j3ja_: 1j3j A: [84066]
        Other proteins in same PDB: d1j3jc_, d1j3jd_
        complexed with cp6, ndp, ump; mutant
      2. 2136846Domain d1j3jb_: 1j3j B: [84067]
        Other proteins in same PDB: d1j3jc_, d1j3jd_
        complexed with cp6, ndp, ump; mutant
    3. Domains for 1j3k:
      1. 2136841Domain d1j3ka_: 1j3k A: [84070]
        Other proteins in same PDB: d1j3kc_, d1j3kd_
        complexed with ndp, ump, wra; mutant
      2. 2136842Domain d1j3kb_: 1j3k B: [84071]
        Other proteins in same PDB: d1j3kc_, d1j3kd_
        complexed with ndp, ump, wra; mutant
    4. Domains for 3dg8:
      1. 2136847Domain d3dg8a_: 3dg8 A: [199230]
        Other proteins in same PDB: d3dg8c_, d3dg8d_
        automated match to d1j3ka_
        complexed with ndp, rj6, ump; mutant
      2. 2136848Domain d3dg8b_: 3dg8 B: [199231]
        Other proteins in same PDB: d3dg8c_, d3dg8d_
        automated match to d1j3kb_
        complexed with ndp, rj6, ump; mutant
    5. Domains for 3dga:
      1. 2136849Domain d3dgaa_: 3dga A: [199232]
        Other proteins in same PDB: d3dgac_, d3dgad_
        automated match to d1j3ia_
        complexed with ndp, rj1, ump
      2. 2136850Domain d3dgab_: 3dga B: [199233]
        Other proteins in same PDB: d3dgac_, d3dgad_
        automated match to d1j3ia_
        complexed with ndp, rj1, ump

More info for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases

Timeline for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases: