Lineage for Protein: Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2903429Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2903430Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2903431Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 2903432Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

Species:

  1. 2903433Cryptosporidium hominis [TaxId:237895] [102636] (15 PDB entries)
    Uniprot Q5CGA3 Q27552
    1. Domains for 1qzf:
      1. 2903434Domain d1qzfa1: 1qzf A:3-180 [96633]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
      2. 2903435Domain d1qzfb1: 1qzf B:3-180 [96635]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
      3. 2903436Domain d1qzfc1: 1qzf C:3-180 [96637]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
      4. 2903437Domain d1qzfd1: 1qzf D:3-180 [96639]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
      5. 2903438Domain d1qzfe1: 1qzf E:3-180 [96641]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
    2. Domains for 1sej:
      1. 2903491Domain d1seja1: 1sej A:3-180 [105455]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
      2. 2903492Domain d1sejb1: 1sej B:3-180 [105457]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
      3. 2903493Domain d1sejc1: 1sej C:3-180 [105459]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
      4. 2903494Domain d1sejd1: 1sej D:3-180 [105461]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
      5. 2903495Domain d1seje1: 1sej E:3-180 [105463]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
    3. Domains for 4q0e:
      1. 2903454Domain d4q0ea1: 4q0e A:3-178 [260370]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
      2. 2903455Domain d4q0eb1: 4q0e B:3-178 [260368]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
      3. 2903456Domain d4q0ec1: 4q0e C:3-178 [260372]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
      4. 2903457Domain d4q0ed1: 4q0e D:3-178 [260376]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
      5. 2903458Domain d4q0ee1: 4q0e E:3-178 [260374]
        Other proteins in same PDB: d4q0ea2, d4q0eb2, d4q0ec2, d4q0ed2, d4q0ee2
        automated match to d1seja1
        complexed with 2xb, ndp, ufp
    4. Domains for 6pf7:
      1. 2903464Domain d6pf7a1: 6pf7 A:3-180 [375065]
        Other proteins in same PDB: d6pf7a2, d6pf7b2, d6pf7c2, d6pf7d2, d6pf7e2
        automated match to d1qzfa1
        complexed with mtx, ndp, og7, so4, ufp
      2. 2903465Domain d6pf7b1: 6pf7 B:3-180 [375111]
        Other proteins in same PDB: d6pf7a2, d6pf7b2, d6pf7c2, d6pf7d2, d6pf7e2
        automated match to d1qzfa1
        complexed with mtx, ndp, og7, so4, ufp
      3. 2903466Domain d6pf7c1: 6pf7 C:3-180 [375138]
        Other proteins in same PDB: d6pf7a2, d6pf7b2, d6pf7c2, d6pf7d2, d6pf7e2
        automated match to d1qzfa1
        complexed with mtx, ndp, og7, so4, ufp
      4. 2903467Domain d6pf7d1: 6pf7 D:3-180 [375063]
        Other proteins in same PDB: d6pf7a2, d6pf7b2, d6pf7c2, d6pf7d2, d6pf7e2
        automated match to d1qzfa1
        complexed with mtx, ndp, og7, so4, ufp
      5. 2903468Domain d6pf7e1: 6pf7 E:3-180 [375129]
        Other proteins in same PDB: d6pf7a2, d6pf7b2, d6pf7c2, d6pf7d2, d6pf7e2
        automated match to d1qzfa1
        complexed with mtx, ndp, og7, so4, ufp
    5. Domains for 6pf8:
      1. 2903439Domain d6pf8a1: 6pf8 A:3-179 [375076]
        Other proteins in same PDB: d6pf8a2, d6pf8b2, d6pf8c2, d6pf8d2, d6pf8e2
        automated match to d1qzfa1
        complexed with mtx, ndp, oe7, ufp
      2. 2903440Domain d6pf8b1: 6pf8 B:3-179 [375134]
        Other proteins in same PDB: d6pf8a2, d6pf8b2, d6pf8c2, d6pf8d2, d6pf8e2
        automated match to d1qzfa1
        complexed with mtx, ndp, oe7, ufp
      3. 2903441Domain d6pf8c1: 6pf8 C:3-178 [375121]
        Other proteins in same PDB: d6pf8a2, d6pf8b2, d6pf8c2, d6pf8d2, d6pf8e2
        automated match to d1qzfa1
        complexed with mtx, ndp, oe7, ufp
      4. 2903442Domain d6pf8d1: 6pf8 D:3-179 [375095]
        Other proteins in same PDB: d6pf8a2, d6pf8b2, d6pf8c2, d6pf8d2, d6pf8e2
        automated match to d1qzfa1
        complexed with mtx, ndp, oe7, ufp
      5. 2903443Domain d6pf8e1: 6pf8 E:3-179 [375044]
        Other proteins in same PDB: d6pf8a2, d6pf8b2, d6pf8c2, d6pf8d2, d6pf8e2
        automated match to d1qzfa1
        complexed with mtx, ndp, oe7, ufp
    6. Domains for 6pf9:
      1. 2903476Domain d6pf9a1: 6pf9 A:3-179 [375067]
        Other proteins in same PDB: d6pf9a2, d6pf9b2, d6pf9c2, d6pf9d2, d6pf9e2
        automated match to d1qzfa1
        complexed with mtx, ndp, of7, so4, ufp
      2. 2903477Domain d6pf9b1: 6pf9 B:3-179 [375108]
        Other proteins in same PDB: d6pf9a2, d6pf9b2, d6pf9c2, d6pf9d2, d6pf9e2
        automated match to d1qzfa1
        complexed with mtx, ndp, of7, so4, ufp
      3. 2903478Domain d6pf9c1: 6pf9 C:3-179 [375093]
        Other proteins in same PDB: d6pf9a2, d6pf9b2, d6pf9c2, d6pf9d2, d6pf9e2
        automated match to d1qzfa1
        complexed with mtx, ndp, of7, so4, ufp
      4. 2903479Domain d6pf9d1: 6pf9 D:3-179 [375072]
        Other proteins in same PDB: d6pf9a2, d6pf9b2, d6pf9c2, d6pf9d2, d6pf9e2
        automated match to d1qzfa1
        complexed with mtx, ndp, of7, so4, ufp
      5. 2903480Domain d6pf9e1: 6pf9 E:3-178 [375046]
        Other proteins in same PDB: d6pf9a2, d6pf9b2, d6pf9c2, d6pf9d2, d6pf9e2
        automated match to d1qzfa1
        complexed with mtx, ndp, of7, so4, ufp
    7. Domains for 6pfa:
      1. 2903459Domain d6pfaa1: 6pfa A:3-179 [375153]
        Other proteins in same PDB: d6pfaa2, d6pfab2, d6pfac2, d6pfad2, d6pfae2
        automated match to d1qzfa1
        complexed with mtx, ndp, of4, so4, ufp
      2. 2903460Domain d6pfab1: 6pfa B:3-179 [375032]
        Other proteins in same PDB: d6pfaa2, d6pfab2, d6pfac2, d6pfad2, d6pfae2
        automated match to d1qzfa1
        complexed with mtx, ndp, of4, so4, ufp
      3. 2903461Domain d6pfac1: 6pfa C:3-178 [375061]
        Other proteins in same PDB: d6pfaa2, d6pfab2, d6pfac2, d6pfad2, d6pfae2
        automated match to d1qzfa1
        complexed with mtx, ndp, of4, so4, ufp
      4. 2903462Domain d6pfad1: 6pfa D:3-179 [375140]
        Other proteins in same PDB: d6pfaa2, d6pfab2, d6pfac2, d6pfad2, d6pfae2
        automated match to d1qzfa1
        complexed with mtx, ndp, of4, so4, ufp
      5. 2903463Domain d6pfae1: 6pfa E:3-179 [375053]
        Other proteins in same PDB: d6pfaa2, d6pfab2, d6pfac2, d6pfad2, d6pfae2
        automated match to d1qzfa1
        complexed with mtx, ndp, of4, so4, ufp
    8. Domains for 6pfb:
      1. 2903501Domain d6pfba1: 6pfb A:3-178 [375048]
        Other proteins in same PDB: d6pfba2, d6pfbb2, d6pfbc2, d6pfbd2, d6pfbe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og4, ufp
      2. 2903502Domain d6pfbb1: 6pfb B:3-178 [375157]
        Other proteins in same PDB: d6pfba2, d6pfbb2, d6pfbc2, d6pfbd2, d6pfbe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og4, ufp
      3. 2903503Domain d6pfbc1: 6pfb C:3-179 [375057]
        Other proteins in same PDB: d6pfba2, d6pfbb2, d6pfbc2, d6pfbd2, d6pfbe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og4, ufp
      4. 2903504Domain d6pfbd1: 6pfb D:3-179 [375074]
        Other proteins in same PDB: d6pfba2, d6pfbb2, d6pfbc2, d6pfbd2, d6pfbe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og4, ufp
      5. 2903505Domain d6pfbe1: 6pfb E:3-178 [375038]
        Other proteins in same PDB: d6pfba2, d6pfbb2, d6pfbc2, d6pfbd2, d6pfbe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og4, ufp
    9. Domains for 6pfc:
      1. 2903444Domain d6pfca1: 6pfc A:3-179 [375815]
        Other proteins in same PDB: d6pfca2, d6pfcb2, d6pfcc2, d6pfcd2, d6pfce2
        automated match to d1qzfa1
        complexed with mtx, ndp, oed, ufp
      2. 2903445Domain d6pfcb1: 6pfc B:3-179 [375819]
        Other proteins in same PDB: d6pfca2, d6pfcb2, d6pfcc2, d6pfcd2, d6pfce2
        automated match to d1qzfa1
        complexed with mtx, ndp, oed, ufp
      3. 2903446Domain d6pfcc1: 6pfc C:3-179 [375827]
        Other proteins in same PDB: d6pfca2, d6pfcb2, d6pfcc2, d6pfcd2, d6pfce2
        automated match to d1qzfa1
        complexed with mtx, ndp, oed, ufp
      4. 2903447Domain d6pfcd1: 6pfc D:3-179 [375843]
        Other proteins in same PDB: d6pfca2, d6pfcb2, d6pfcc2, d6pfcd2, d6pfce2
        automated match to d1qzfa1
        complexed with mtx, ndp, oed, ufp
      5. 2903448Domain d6pfce1: 6pfc E:3-179 [375821]
        Other proteins in same PDB: d6pfca2, d6pfcb2, d6pfcc2, d6pfcd2, d6pfce2
        automated match to d1qzfa1
        complexed with mtx, ndp, oed, ufp
    10. Domains for 6pfe:
      1. 2903469Domain d6pfea1: 6pfe A:3-179 [375034]
        Other proteins in same PDB: d6pfea2, d6pfeb2, d6pfec2, d6pfed2, d6pfee2
        automated match to d1qzfa1
        complexed with mtx, ndp, oea, ufp
      2. 2903470Domain d6pfeb1: 6pfe B:3-179 [375234]
        Other proteins in same PDB: d6pfea2, d6pfeb2, d6pfec2, d6pfed2, d6pfee2
        automated match to d1qzfa1
        complexed with mtx, ndp, oea, ufp
      3. 2903471Domain d6pfec1: 6pfe C:3-180 [375040]
        Other proteins in same PDB: d6pfea2, d6pfeb2, d6pfec2, d6pfed2, d6pfee2
        automated match to d1qzfa1
        complexed with mtx, ndp, oea, ufp
      4. 2903472Domain d6pfed1: 6pfe D:3-180 [375082]
        Other proteins in same PDB: d6pfea2, d6pfeb2, d6pfec2, d6pfed2, d6pfee2
        automated match to d1qzfa1
        complexed with mtx, ndp, oea, ufp
      5. 2903473Domain d6pfee1: 6pfe E:3-178 [375178]
        Other proteins in same PDB: d6pfea2, d6pfeb2, d6pfec2, d6pfed2, d6pfee2
        automated match to d1qzfa1
        complexed with mtx, ndp, oea, ufp
    11. Domains for 6pff:
      1. 2903496Domain d6pffa1: 6pff A:3-179 [375091]
        Other proteins in same PDB: d6pffa2, d6pffb2, d6pffc2, d6pffd2, d6pffe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og1, so4, ufp
      2. 2903497Domain d6pffb1: 6pff B:3-179 [375127]
        Other proteins in same PDB: d6pffa2, d6pffb2, d6pffc2, d6pffd2, d6pffe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og1, so4, ufp
      3. 2903498Domain d6pffc1: 6pff C:3-179 [375147]
        Other proteins in same PDB: d6pffa2, d6pffb2, d6pffc2, d6pffd2, d6pffe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og1, so4, ufp
      4. 2903499Domain d6pffd1: 6pff D:3-179 [375149]
        Other proteins in same PDB: d6pffa2, d6pffb2, d6pffc2, d6pffd2, d6pffe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og1, so4, ufp
      5. 2903500Domain d6pffe1: 6pff E:3-179 [375184]
        Other proteins in same PDB: d6pffa2, d6pffb2, d6pffc2, d6pffd2, d6pffe2
        automated match to d1qzfa1
        complexed with mtx, ndp, og1, so4, ufp
    12. Domains for 6pfg:
      1. 2903449Domain d6pfga1: 6pfg A:3-178 [375028]
        Other proteins in same PDB: d6pfga2, d6pfgb2, d6pfgc2, d6pfgd2, d6pfge2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofj, so4, ufp
      2. 2903450Domain d6pfgb1: 6pfg B:3-179 [375069]
        Other proteins in same PDB: d6pfga2, d6pfgb2, d6pfgc2, d6pfgd2, d6pfge2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofj, so4, ufp
      3. 2903451Domain d6pfgc1: 6pfg C:3-179 [375030]
        Other proteins in same PDB: d6pfga2, d6pfgb2, d6pfgc2, d6pfgd2, d6pfge2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofj, so4, ufp
      4. 2903452Domain d6pfgd1: 6pfg D:3-179 [375099]
        Other proteins in same PDB: d6pfga2, d6pfgb2, d6pfgc2, d6pfgd2, d6pfge2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofj, so4, ufp
      5. 2903453Domain d6pfge1: 6pfg E:3-179 [375101]
        Other proteins in same PDB: d6pfga2, d6pfgb2, d6pfgc2, d6pfgd2, d6pfge2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofj, so4, ufp
    13. Domains for 6pfh:
      1. 2903486Domain d6pfha1: 6pfh A:3-180 [375050]
        Other proteins in same PDB: d6pfha2, d6pfhb2, d6pfhc2, d6pfhd2, d6pfhe2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofd, ufp
      2. 2903487Domain d6pfhb1: 6pfh B:3-179 [375145]
        Other proteins in same PDB: d6pfha2, d6pfhb2, d6pfhc2, d6pfhd2, d6pfhe2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofd, ufp
      3. 2903488Domain d6pfhc1: 6pfh C:3-179 [375086]
        Other proteins in same PDB: d6pfha2, d6pfhb2, d6pfhc2, d6pfhd2, d6pfhe2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofd, ufp
      4. 2903489Domain d6pfhd1: 6pfh D:3-180 [375036]
        Other proteins in same PDB: d6pfha2, d6pfhb2, d6pfhc2, d6pfhd2, d6pfhe2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofd, ufp
      5. 2903490Domain d6pfhe1: 6pfh E:3-179 [375165]
        Other proteins in same PDB: d6pfha2, d6pfhb2, d6pfhc2, d6pfhd2, d6pfhe2
        automated match to d1qzfa1
        complexed with mtx, ndp, ofd, ufp
    14. Domains for 6pfi:
      1. 2903481Domain d6pfia1: 6pfi A:3-179 [375106]
        Other proteins in same PDB: d6pfia2, d6pfib2, d6pfic2, d6pfid2, d6pfie2
        automated match to d1qzfa1
        complexed with mtx, ndp, oep, ufp
      2. 2903482Domain d6pfib1: 6pfi B:3-180 [375084]
        Other proteins in same PDB: d6pfia2, d6pfib2, d6pfic2, d6pfid2, d6pfie2
        automated match to d1qzfa1
        complexed with mtx, ndp, oep, ufp
      3. 2903483Domain d6pfic1: 6pfi C:3-179 [375059]
        Other proteins in same PDB: d6pfia2, d6pfib2, d6pfic2, d6pfid2, d6pfie2
        automated match to d1qzfa1
        complexed with mtx, ndp, oep, ufp
      4. 2903484Domain d6pfid1: 6pfi D:3-180 [375190]
        Other proteins in same PDB: d6pfia2, d6pfib2, d6pfic2, d6pfid2, d6pfie2
        automated match to d1qzfa1
        complexed with mtx, ndp, oep, ufp
      5. 2903485Domain d6pfie1: 6pfi E:3-179 [375055]
        Other proteins in same PDB: d6pfia2, d6pfib2, d6pfic2, d6pfid2, d6pfie2
        automated match to d1qzfa1
        complexed with mtx, ndp, oep, ufp
    15. Domains for 6wep:
      1. 2903474Domain d6wepa1: 6wep A:3-178 [388019]
        Other proteins in same PDB: d6wepa2, d6wepb2
        automated match to d1qzfa1
        complexed with mtx, ndp
      2. 2903475Domain d6wepb1: 6wep B:3-178 [388015]
        Other proteins in same PDB: d6wepa2, d6wepb2
        automated match to d1qzfa1
        complexed with mtx, ndp
  2. 2903506Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)
    1. Domains for 1j3i:
      1. 2903509Domain d1j3ia_: 1j3i A: [84062]
        Other proteins in same PDB: d1j3ic_, d1j3id_
        complexed with ndp, ump, wra
      2. 2903510Domain d1j3ib_: 1j3i B: [84063]
        Other proteins in same PDB: d1j3ic_, d1j3id_
        complexed with ndp, ump, wra
    2. Domains for 1j3j:
      1. 2903511Domain d1j3ja_: 1j3j A: [84066]
        Other proteins in same PDB: d1j3jc_, d1j3jd_
        complexed with cp6, ndp, ump; mutant
      2. 2903512Domain d1j3jb_: 1j3j B: [84067]
        Other proteins in same PDB: d1j3jc_, d1j3jd_
        complexed with cp6, ndp, ump; mutant
    3. Domains for 1j3k:
      1. 2903507Domain d1j3ka_: 1j3k A: [84070]
        Other proteins in same PDB: d1j3kc_, d1j3kd_
        complexed with ndp, ump, wra; mutant
      2. 2903508Domain d1j3kb_: 1j3k B: [84071]
        Other proteins in same PDB: d1j3kc_, d1j3kd_
        complexed with ndp, ump, wra; mutant
    4. Domains for 3dg8:
      1. 2903513Domain d3dg8a_: 3dg8 A: [199230]
        Other proteins in same PDB: d3dg8c_, d3dg8d_
        automated match to d1j3ka_
        complexed with ndp, rj6, ump; mutant
      2. 2903514Domain d3dg8b_: 3dg8 B: [199231]
        Other proteins in same PDB: d3dg8c_, d3dg8d_
        automated match to d1j3kb_
        complexed with ndp, rj6, ump; mutant
    5. Domains for 3dga:
      1. 2903515Domain d3dgaa_: 3dga A: [199232]
        Other proteins in same PDB: d3dgac_, d3dgad_
        automated match to d1j3ia_
        complexed with ndp, rj1, ump
      2. 2903516Domain d3dgab_: 3dga B: [199233]
        Other proteins in same PDB: d3dgac_, d3dgad_
        automated match to d1j3ia_
        complexed with ndp, rj1, ump

More info for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases

Timeline for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases: