SCOPe 2.08: Domain d6pfid1: 6pfi D:3-180

Lineage for d6pfid1 (6pfi D:3-180)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [102636] (15 PDB entries)
   Uniprot Q5CGA3 Q27552

8. Domain d6pfid1: 6pfi D:3-180 [375190]
   Other proteins in same PDB: d6pfia2, d6pfib2, d6pfic2, d6pfid2, d6pfie2
   automated match to d1qzfa1
   complexed with mtx, ndp, oep, ufp

Details for d6pfid1

PDB Entry: 6pfi, 2.89 Å

PDB Description: crystal structure of ts-dhfr from cryptosporidium hominis in complex with nadph, fdump and 3-(4-((2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2, 3-d]pyrimidin-5-yl)methyl)benzamido)-4-(carboxymethyl)benzoic acid.

PDB Compounds: (D:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d6pfid1:

Sequence; same for both SEQRES and ATOM records:

>d6pfid1 c.71.1.1 (D:3-180) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Cryptosporidium hominis [TaxId: 237895]}
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqek

Timeline for d6pfid1:

• d6pfid1 first appeared in SCOPe 2.07