Lineage for Family c.71.1.1: Dihydrofolate reductases

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

Proteins:

  1. Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)
    1. Species Cryptosporidium hominis [TaxId:237895] [102636] (15 PDB entries)
      Uniprot Q5CGA3 Q27552
    2. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)
  2. Dihydrofolate reductase, prokaryotic type [53599] (9 species)
    1. Species Bacteriophage T4 [TaxId:10665] [102635] (1 PDB entry)
    2. Species Escherichia coli K-12 [TaxId:83333] [187149] (11 PDB entries)
    3. Species Escherichia coli [TaxId:562] [53600] (86 PDB entries)
    4. Species Haloferax volcanii [TaxId:2246] [53604] (3 PDB entries)
    5. Species Lactobacillus casei [TaxId:1582] [53601] (10 PDB entries)
    6. Species Mycobacterium tuberculosis [TaxId:1773] [53602] (23 PDB entries)
    7. Species Mycobacterium tuberculosis [TaxId:419947] [370794] (5 PDB entries)
    8. Species Staphylococcus aureus [TaxId:1280] [188976] (32 PDB entries)
    9. Species Thermotoga maritima [TaxId:2336] [53603] (2 PDB entries)
  3. Dihydrofolate reductases, eukaryotic type [53605] (7 species)
    1. Species Candida glabrata [TaxId:284593] [237803] (4 PDB entries)
    2. Species Candida glabrata [TaxId:5478] [188672] (1 PDB entry)
    3. Species Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries)
    4. Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (25 PDB entries)
    5. Species Human (Homo sapiens) [TaxId:9606] [53607] (79 PDB entries)
    6. Species Mouse (Mus musculus) [TaxId:10090] [187727] (6 PDB entries)
    7. Species Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries)
  4. automated matches [190514] (12 species)
    not a true protein
    1. Species Escherichia coli [TaxId:562] [187587] (3 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [188894] (2 PDB entries)
    3. Species Klebsiella pneumoniae [TaxId:1244085] [261371] (2 PDB entries)
    4. Species Mycobacterium avium [TaxId:1764] [189124] (2 PDB entries)
    5. Species Mycobacterium kansasii [TaxId:1768] [402137] (1 PDB entry)
    6. Species Mycobacterium tuberculosis [TaxId:1773] [327514] (2 PDB entries)
    7. Species Mycobacterium ulcerans [TaxId:362242] [395872] (10 PDB entries)
    8. Species Plasmodium vivax [TaxId:5855] [187469] (4 PDB entries)
    9. Species Pneumocystis jirovecii [TaxId:42068] [197174] (1 PDB entry)
    10. Species Staphylococcus aureus [TaxId:1280] [195885] (5 PDB entries)
    11. Species Staphylococcus aureus [TaxId:273036] [274776] (1 PDB entry)
    12. Species Yersinia pestis [TaxId:214092] [314715] (1 PDB entry)

More info for Family c.71.1.1: Dihydrofolate reductases

Timeline for Family c.71.1.1: Dihydrofolate reductases: