Lineage for Family c.71.1.1: Dihydrofolate reductases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)

Protein Domains:

  1. 2136823Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)
    1. 2136824Species Cryptosporidium hominis [TaxId:237895] [102636] (3 PDB entries)
      Uniprot Q5CGA3 Q27552
    2. 2136840Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)
  2. 2136851Dihydrofolate reductase, prokaryotic type [53599] (8 species)
    1. 2136852Species Bacteriophage T4 [TaxId:10665] [102635] (1 PDB entry)
    2. 2136854Species Escherichia coli K-12 [TaxId:83333] [187149] (6 PDB entries)
    3. 2136861Species Escherichia coli [TaxId:562] [53600] (79 PDB entries)
    4. 2136962Species Haloferax volcanii [TaxId:2246] [53604] (3 PDB entries)
    5. 2136967Species Lactobacillus casei [TaxId:1582] [53601] (10 PDB entries)
    6. 2136978Species Mycobacterium tuberculosis [TaxId:1773] [53602] (6 PDB entries)
    7. 2136984Species Staphylococcus aureus [TaxId:1280] [188976] (25 PDB entries)
    8. 2137006Species Thermotoga maritima [TaxId:2336] [53603] (2 PDB entries)
  3. 2137011Dihydrofolate reductases, eukaryotic type [53605] (7 species)
    1. 2137012Species Candida glabrata [TaxId:284593] [237803] (4 PDB entries)
    2. 2137021Species Candida glabrata [TaxId:5478] [188672] (1 PDB entry)
    3. 2137024Species Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries)
    4. 2137033Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (25 PDB entries)
    5. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)
    6. 2137135Species Mouse (Mus musculus) [TaxId:10090] [187727] (6 PDB entries)
    7. 2137142Species Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries)
  4. 2137177automated matches [190514] (11 species)
    not a true protein
    1. 2137178Species Escherichia coli [TaxId:562] [187587] (3 PDB entries)
    2. 2137183Species Human (Homo sapiens) [TaxId:9606] [188894] (2 PDB entries)
    3. 2137186Species Klebsiella pneumoniae [TaxId:1244085] [261371] (2 PDB entries)
    4. 2137192Species Mycobacterium avium [TaxId:1764] [189124] (2 PDB entries)
    5. 2137195Species Plasmodium vivax [TaxId:5855] [187469] (4 PDB entries)
    6. 2137200Species Pneumocystis jirovecii [TaxId:42068] [197174] (1 PDB entry)
    7. 2137202Species Staphylococcus aureus [TaxId:1280] [195885] (5 PDB entries)
    8. 2137211Species Staphylococcus aureus [TaxId:273036] [274776] (1 PDB entry)
    9. 2271411Species Yersinia pestis [TaxId:214092] [314715] (1 PDB entry)
    10. 2284213Species Mycobacterium tuberculosis [TaxId:1773] [327514] (2 PDB entries)
    11. 2286058Species Mycobacterium tuberculosis [TaxId:83332] [329359] (1 PDB entry)

More info for Family c.71.1.1: Dihydrofolate reductases

Timeline for Family c.71.1.1: Dihydrofolate reductases: