SCOPe 2.08: Family c.71.1.1: Dihydrofolate reductases

Lineage for Family c.71.1.1: Dihydrofolate reductases

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

Proteins:

1. Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

   1. Species Cryptosporidium hominis [TaxId:237895] [102636] (15 PDB entries)
      Uniprot Q5CGA3 Q27552

   2. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)

2. Dihydrofolate reductase, prokaryotic type [53599] (9 species)

   1. Species Bacteriophage T4 [TaxId:10665] [102635] (1 PDB entry)

   2. Species Escherichia coli K-12 [TaxId:83333] [187149] (11 PDB entries)

   3. Species Escherichia coli [TaxId:562] [53600] (86 PDB entries)

   4. Species Haloferax volcanii [TaxId:2246] [53604] (3 PDB entries)

   5. Species Lactobacillus casei [TaxId:1582] [53601] (10 PDB entries)

   6. Species Mycobacterium tuberculosis [TaxId:1773] [53602] (24 PDB entries)

   7. Species Mycobacterium tuberculosis [TaxId:419947] [370794] (5 PDB entries)

   8. Species Staphylococcus aureus [TaxId:1280] [188976] (33 PDB entries)

   9. Species Thermotoga maritima [TaxId:2336] [53603] (2 PDB entries)

3. Dihydrofolate reductases, eukaryotic type [53605] (7 species)

   1. Species Candida glabrata [TaxId:284593] [237803] (4 PDB entries)

   2. Species Candida glabrata [TaxId:5478] [188672] (1 PDB entry)

   3. Species Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries)

   4. Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (25 PDB entries)

   5. Species Human (Homo sapiens) [TaxId:9606] [53607] (80 PDB entries)

   6. Species Mouse (Mus musculus) [TaxId:10090] [187727] (6 PDB entries)

   7. Species Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries)

4. automated matches [190514] (12 species)
   not a true protein

   1. Species Escherichia coli [TaxId:562] [187587] (3 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [188894] (2 PDB entries)

   3. Species Klebsiella pneumoniae [TaxId:1244085] [261371] (2 PDB entries)

   4. Species Mycobacterium avium [TaxId:1764] [189124] (2 PDB entries)

   5. Species Mycobacterium kansasii [TaxId:1768] [402137] (1 PDB entry)

   6. Species Mycobacterium tuberculosis [TaxId:1773] [327514] (2 PDB entries)

   7. Species Mycobacterium ulcerans [TaxId:362242] [395872] (10 PDB entries)

   8. Species Plasmodium vivax [TaxId:5855] [187469] (4 PDB entries)

   9. Species Pneumocystis jirovecii [TaxId:42068] [197174] (1 PDB entry)

   10. Species Staphylococcus aureus [TaxId:1280] [195885] (5 PDB entries)

   11. Species Staphylococcus aureus [TaxId:273036] [274776] (1 PDB entry)

   12. Species Yersinia pestis [TaxId:214092] [314715] (1 PDB entry)

More info for Family c.71.1.1: Dihydrofolate reductases

Timeline for Family c.71.1.1: Dihydrofolate reductases:

• Family c.71.1.1: Dihydrofolate reductases first appeared (with stable ids) in SCOP 1.55
  
• Family c.71.1.1: Dihydrofolate reductases appears in SCOPe 2.07