Lineage for Protein: Dihydrofolate reductases, eukaryotic type

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137011Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

Species:

  1. 2137012Candida glabrata [TaxId:284593] [237803] (4 PDB entries)
    1. Domains for 3ro9:
      1. 2137017Domain d3ro9a1: 3ro9 A:3-217 [200501]
        Other proteins in same PDB: d3ro9a2, d3ro9b2
        automated match to d3ro9b_
        complexed with 06u, ndp
      2. 2137018Domain d3ro9b1: 3ro9 B:3-217 [193189]
        Other proteins in same PDB: d3ro9a2, d3ro9b2
        automated match to d3csea_
        complexed with 06u, ndp
    2. Domains for 3roa:
      1. 2137015Domain d3roaa1: 3roa A:3-217 [215949]
        Other proteins in same PDB: d3roaa2, d3roab2
        automated match to d3ro9b_
        complexed with 06v, cl, ndp
      2. 2137016Domain d3roab1: 3roa B:3-217 [215950]
        Other proteins in same PDB: d3roaa2, d3roab2
        automated match to d3ro9b_
        complexed with 06v, cl, ndp
    3. Domains for 4h98:
      1. 2137019Domain d4h98a1: 4h98 A:4-217 [202388]
        Other proteins in same PDB: d4h98a2, d4h98b2
        automated match to d4h98b_
        complexed with 14q, ndp
      2. 2137020Domain d4h98b1: 4h98 B:4-217 [196719]
        Other proteins in same PDB: d4h98a2, d4h98b2
        automated match to d3csea_
        complexed with 14q, ndp
    4. Domains for 4hog:
      1. 2137013Domain d4hoga1: 4hog A:3-217 [237804]
        Other proteins in same PDB: d4hoga2, d4hogb2
        automated match to d3csea_
        complexed with 18h, cl, ndp
      2. 2137014Domain d4hogb1: 4hog B:3-217 [237806]
        Other proteins in same PDB: d4hoga2, d4hogb2
        automated match to d3csea_
        complexed with 18h, cl, ndp
  2. 2137021Candida glabrata [TaxId:5478] [188672] (1 PDB entry)
  3. 2137024Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries)
    1. Domain for 1dr1:
    2. Domain for 1dr2:
    3. Domain for 1dr3:
    4. Domain for 1dr4:
    5. Domain for 1dr5:
    6. Domain for 1dr6:
    7. Domain for 1dr7:
    8. Domain for 8dfr:
  4. 2137033Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (25 PDB entries)
    1. Domain for 1cd2:
    2. Domain for 1d8r:
    3. Domain for 1daj:
    4. Domain for 1dyr:
    5. Domain for 1e26:
    6. Domain for 1klk:
    7. Domain for 1ly3:
    8. Domain for 1ly4:
    9. Domain for 1s3y:
    10. Domain for 1vj3:
    11. Domain for 2cd2:
    12. Domain for 2fzh:
    13. Domain for 2fzi:
    14. Domain for 3cd2:
    15. Domain for 3nz6:
    16. Domain for 3nz9:
    17. Domain for 3nza:
    18. Domain for 3nzb:
    19. Domain for 3nzc:
    20. Domain for 3td8:
    21. Domain for 4cd2:
    22. Domain for 4ixe:
    23. Domain for 4ixf:
    24. Domain for 4ixg:
    25. Domain for 4qjz:
  5. 2137059Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)
    1. Domain for 1boz:
    2. Domains for 1dhf:
      1. 2137121Domain d1dhfa_: 1dhf A: [34910]
        complexed with fol
      2. 2137122Domain d1dhfb_: 1dhf B: [34911]
        complexed with fol
    3. Domain for 1dlr:
    4. Domain for 1dls:
    5. Domain for 1drf:
    6. Domain for 1hfp:
    7. Domain for 1hfq:
    8. Domain for 1hfr:
    9. Domain for 1kms:
    10. Domain for 1kmv:
    11. Domain for 1mvs:
    12. Domain for 1mvt:
    13. Domain for 1ohj:
    14. Domain for 1ohk:
    15. Domain for 1pd8:
    16. Domain for 1pd9:
    17. Domain for 1pdb:
    18. Domain for 1s3u:
    19. Domain for 1s3v:
    20. Domain for 1s3w:
    21. Domain for 1u71:
    22. Domain for 1u72:
    23. Domain for 1yho:
    24. Domains for 2c2s:
      1. 2137069Domain d2c2sa_: 2c2s A: [129682]
        automated match to d1drf__
        complexed with 34b, gol, ndp
      2. 2137070Domain d2c2sb_: 2c2s B: [129683]
        automated match to d1drf__
        complexed with 34b, gol, ndp
    25. Domains for 2c2t:
      1. 2137075Domain d2c2ta_: 2c2t A: [129684]
        automated match to d1drf__
        complexed with 39b, 39e, gol, ndp
      2. 2137076Domain d2c2tb_: 2c2t B: [129685]
        automated match to d1drf__
        complexed with 39b, 39e, gol, ndp
    26. Domains for 2dhf:
      1. 2137127Domain d2dhfa_: 2dhf A: [34912]
        complexed with dzf
      2. 2137128Domain d2dhfb_: 2dhf B: [34913]
        complexed with dzf
    27. Domains for 2w3a:
      1. 2137079Domain d2w3aa_: 2w3a A: [169035]
        automated match to d1dlra_
        complexed with gol, ndp, so4, top
      2. 2137080Domain d2w3ab_: 2w3a B: [169036]
        automated match to d1dlra_
        complexed with gol, ndp, so4, top
    28. Domains for 2w3b:
      1. 2137063Domain d2w3ba_: 2w3b A: [169037]
        automated match to d1dlra_
        complexed with fol, k, ndp, vg9
      2. 2137064Domain d2w3bb_: 2w3b B: [169038]
        automated match to d1dlra_
        complexed with fol, k, ndp, vg9
    29. Domains for 2w3m:
      1. 2137083Domain d2w3ma_: 2w3m A: [169045]
        automated match to d1dlra_
        complexed with fol, ndp
      2. 2137084Domain d2w3mb_: 2w3m B: [169046]
        automated match to d1dlra_
        complexed with fol, ndp
    30. Domain for 3eig:
    31. Domain for 3f8y:
    32. Domain for 3f8z:
    33. Domain for 3f91:
    34. Domain for 3fs6:
    35. Domain for 3ghc:
    36. Domain for 3ghv:
    37. Domain for 3ghw:
    38. Domain for 3gi2:
    39. Domain for 3gyf:
    40. Domain for 3l3r:
    41. Domain for 3ntz:
    42. Domain for 3nu0:
    43. Domain for 3nxo:
    44. Domain for 3nxr:
    45. Domain for 3nxt:
    46. Domain for 3nxv:
    47. Domain for 3nxx:
    48. Domain for 3nxy:
    49. Domain for 3nzd:
    50. Domain for 3oaf:
    51. Domain for 3s7a:
    52. Domain for 4ddr:
    53. Domain for 4g95:
    54. Domains for 4kak:
      1. 2137109Domain d4kaka_: 4kak A: [228206]
        automated match to d1kmva_
        complexed with 06u, ca, eoh, ndp
      2. 2137110Domain d4kakb_: 4kak B: [228207]
        automated match to d1kmva_
        complexed with 06u, ca, eoh, ndp
    55. Domains for 4kbn:
      1. 2137115Domain d4kbna_: 4kbn A: [228209]
        automated match to d1kmva_
        complexed with 25u, cl, eoh, mg, ndp, nh4, sr
      2. 2137116Domain d4kbnb_: 4kbn B: [228208]
        automated match to d1kmva_
        complexed with 25u, cl, eoh, mg, ndp, nh4, sr
    56. Domains for 4kd7:
      1. 2137130Domain d4kd7a_: 4kd7 A: [228211]
        automated match to d1kmva_
        complexed with 9dr, ndp, so4
      2. 2137131Domain d4kd7b_: 4kd7 B: [228210]
        automated match to d1kmva_
        complexed with 9dr, ndp, so4
    57. Domains for 4keb:
      1. 2137085Domain d4keba_: 4keb A: [228213]
        automated match to d1kmva_
        complexed with 1qz, fol, ndp
      2. 2137086Domain d4kebb_: 4keb B: [228212]
        automated match to d1kmva_
        complexed with 1qz, fol, ndp
    58. Domains for 4kfj:
      1. 2137103Domain d4kfja_: 4kfj A: [228220]
        automated match to d1kmva_
        complexed with 1r0, cl, eoh, fol, mg, ndp
      2. 2137104Domain d4kfjb_: 4kfj B: [228221]
        automated match to d1kmva_
        complexed with 1r0, cl, eoh, fol, mg, ndp
    59. Domain for 4m6j:
    60. Domain for 4m6k:
    61. Domain for 4m6l:
    62. Domain for 4qhv:
    63. Domain for 4qjc:
    64. Domain for 5hpb:
    65. Domain for 5hqy:
    66. Domain for 5hqz:
    67. Domain for 5hsr:
    68. Domain for 5hsu:
    69. Domain for 5ht4:
    70. Domain for 5ht5:
    71. Domain for 5hui:
    72. Domain for 5hvb:
    73. Domain for 5hve:
  6. 2137135Mouse (Mus musculus) [TaxId:10090] [187727] (6 PDB entries)
    1. Domain for 1u70:
    2. Domain for 2fzj:
    3. Domain for 3d80:
    4. Domain for 3d84:
    5. Domain for 3k45:
    6. Domain for 3k47:
  7. 2137142Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries)
    1. Domains for 1ai9:
      1. 2137161Domain d1ai9a_: 1ai9 A: [34925]
        complexed with ndp
      2. 2137162Domain d1ai9b_: 1ai9 B: [34926]
        complexed with ndp
    2. Domains for 1aoe:
      1. 2137143Domain d1aoea_: 1aoe A: [34923]
        complexed with gw3, ndp
      2. 2137144Domain d1aoeb_: 1aoe B: [34924]
        complexed with gw3, ndp
    3. Domains for 1ia1:
      1. 2137151Domain d1ia1a_: 1ia1 A: [62103]
        complexed with ndp, po4, tq3
      2. 2137152Domain d1ia1b_: 1ia1 B: [62104]
        complexed with ndp, po4, tq3
    4. Domains for 1ia2:
      1. 2137155Domain d1ia2a_: 1ia2 A: [62105]
        complexed with mes, ndp, tq4
      2. 2137156Domain d1ia2b_: 1ia2 B: [62106]
        complexed with mes, ndp, tq4
    5. Domains for 1ia3:
      1. 2137153Domain d1ia3a_: 1ia3 A: [62107]
        complexed with mes, ndp, tq5
      2. 2137154Domain d1ia3b_: 1ia3 B: [62108]
        complexed with mes, ndp, tq5
    6. Domains for 1ia4:
      1. 2137157Domain d1ia4a_: 1ia4 A: [62109]
        complexed with mes, ndp, tq6
      2. 2137158Domain d1ia4b_: 1ia4 B: [62110]
        complexed with mes, ndp, tq6
    7. Domains for 1m78:
      1. 2137147Domain d1m78a_: 1m78 A: [84855]
        complexed with clz, ndp
      2. 2137148Domain d1m78b_: 1m78 B: [84856]
        complexed with clz, ndp
    8. Domains for 1m79:
      1. 2137145Domain d1m79a_: 1m79 A: [84857]
        complexed with mes, mq1, ndp
      2. 2137146Domain d1m79b_: 1m79 B: [84858]
        complexed with mes, mq1, ndp
    9. Domains for 1m7a:
      1. 2137149Domain d1m7aa_: 1m7a A: [84859]
        complexed with mqu, ndp
      2. 2137150Domain d1m7ab_: 1m7a B: [84860]
        complexed with mqu, ndp
    10. Domains for 3qlr:
      1. 2137167Domain d3qlra1: 3qlr A:3-192 [184476]
        Other proteins in same PDB: d3qlra2, d3qlrb2
        automated match to d1ai9a_
        complexed with gly, gol, ndp, qlr
      2. 2137168Domain d3qlrb1: 3qlr B:3-192 [184477]
        Other proteins in same PDB: d3qlra2, d3qlrb2
        automated match to d1ai9a_
        complexed with gly, gol, ndp, qlr
    11. Domains for 3qls:
      1. 2137159Domain d3qlsa1: 3qls A:3-192 [184478]
        Other proteins in same PDB: d3qlsa2, d3qlsb2
        automated match to d1ai9a_
        complexed with 55v, gly, gol, ndp
      2. 2137160Domain d3qlsb1: 3qls B:3-192 [184479]
        Other proteins in same PDB: d3qlsa2, d3qlsb2
        automated match to d1ai9a_
        complexed with 55v, gly, gol, ndp
    12. Domains for 3qlw:
      1. 2137171Domain d3qlwa_: 3qlw A: [184480]
        automated match to d1ai9a_
        complexed with n22, ndp
      2. 2137172Domain d3qlwb_: 3qlw B: [184481]
        automated match to d1ai9a_
        complexed with n22, ndp
    13. Domains for 4h95:
      1. 2137173Domain d4h95a_: 4h95 A: [222440]
        automated match to d4h96a_
        complexed with 06u, ndp
      2. 2137174Domain d4h95b_: 4h95 B: [222441]
        automated match to d4h96a_
        complexed with 06u, ndp
    14. Domains for 4h96:
      1. 2137175Domain d4h96a_: 4h96 A: [196717]
        automated match to d1aoea_
        complexed with 14q, ndp
      2. 2137176Domain d4h96b_: 4h96 B: [202386]
        automated match to d4h96a_
        complexed with 14q, ndp
    15. Domains for 4h97:
      1. 2137169Domain d4h97a1: 4h97 A:4-192 [202387]
        Other proteins in same PDB: d4h97a2, d4h97b2
        automated match to d4h97b_
        complexed with 53s, gol, ndp
      2. 2137170Domain d4h97b1: 4h97 B:4-192 [196722]
        Other proteins in same PDB: d4h97a2, d4h97b2
        automated match to d1aoea_
        complexed with 53s, gol, ndp
    16. Domains for 4hoe:
      1. 2137165Domain d4hoea_: 4hoe A: [237805]
        automated match to d1aoea_
        complexed with 18g, gly, gol, ndp
      2. 2137166Domain d4hoeb_: 4hoe B: [237807]
        automated match to d1aoea_
        complexed with 18g, gly, gol, ndp
    17. Domains for 4hof:
      1. 2137163Domain d4hofa_: 4hof A: [237808]
        automated match to d1aoea_
        complexed with 18h, gly, gol, ndp
      2. 2137164Domain d4hofb_: 4hof B: [237809]
        automated match to d1aoea_
        complexed with 18h, gly, gol, ndp

More info for Protein Dihydrofolate reductases, eukaryotic type from c.71.1.1: Dihydrofolate reductases

Timeline for Protein Dihydrofolate reductases, eukaryotic type from c.71.1.1: Dihydrofolate reductases: