Lineage for Protein: Dihydrofolate reductase, prokaryotic type

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2136851Protein Dihydrofolate reductase, prokaryotic type [53599] (8 species)

Species:

  1. 2136852Bacteriophage T4 [TaxId:10665] [102635] (1 PDB entry)
  2. 2136854Escherichia coli K-12 [TaxId:83333] [187149] (6 PDB entries)
    1. Domains for 2inq:
      1. 2136859Domain d2inqa_: 2inq A: [137531]
        automated match to d1dre__
        complexed with mt1
      2. 2136860Domain d2inqb_: 2inq B: [137532]
        automated match to d1dre__
        complexed with mt1
    2. Domain for 3k74:
    3. Domain for 3qyl:
    4. Domain for 3qyo:
    5. Domain for 3r33:
    6. Domain for 5uih:
  3. 2136861Escherichia coli [TaxId:562] [53600] (79 PDB entries)
    1. Domains for 1ddr:
      1. 2136941Domain d1ddra_: 1ddr A: [34856]
        complexed with ca, cl, mtx, ure
      2. 2136942Domain d1ddrb_: 1ddr B: [34857]
        complexed with ca, cl, mtx, ure
    2. Domains for 1dds:
      1. 2136932Domain d1ddsa_: 1dds A: [34858]
        complexed with ca, cl, mtx
      2. 2136933Domain d1ddsb_: 1dds B: [34859]
        complexed with ca, cl, mtx
    3. Domains for 1dhi:
      1. 2136910Domain d1dhia_: 1dhi A: [34844]
        complexed with ca, cl, mtx; mutant
      2. 2136911Domain d1dhib_: 1dhi B: [34845]
        complexed with ca, cl, mtx; mutant
    4. Domains for 1dhj:
      1. 2136897Domain d1dhja_: 1dhj A: [34833]
        complexed with ca, cl, mtx; mutant
      2. 2136898Domain d1dhjb_: 1dhj B: [34834]
        complexed with ca, cl, mtx; mutant
    5. Domains for 1dra:
      1. 2136892Domain d1draa_: 1dra A: [34831]
        complexed with ca, cl, mtx
      2. 2136893Domain d1drab_: 1dra B: [34832]
        complexed with ca, cl, mtx
    6. Domains for 1drb:
      1. 2136901Domain d1drba_: 1drb A: [34828]
        complexed with ca, cl, eoh, mtx
      2. 2136902Domain d1drbb_: 1drb B: [34829]
        complexed with ca, cl, eoh, mtx
    7. Domain for 1dre:
    8. Domain for 1drh:
    9. Domains for 1dyh:
      1. 2136908Domain d1dyha_: 1dyh A: [34842]
        complexed with ca, cl, dzf
      2. 2136909Domain d1dyhb_: 1dyh B: [34843]
        complexed with ca, cl, dzf
    10. Domains for 1dyi:
      1. 2136895Domain d1dyia_: 1dyi A: [34837]
        complexed with ca, cl, fol
      2. 2136896Domain d1dyib_: 1dyi B: [34838]
        complexed with ca, cl, fol
    11. Domains for 1dyj:
      1. 2136890Domain d1dyja_: 1dyj A: [34826]
        complexed with ca, cl, ddf
      2. 2136891Domain d1dyjb_: 1dyj B: [34827]
        complexed with ca, cl, ddf
    12. Domains for 1jol:
      1. 2136914Domain d1jola_: 1jol A: [34846]
        complexed with ca, cl, ffo
      2. 2136915Domain d1jolb_: 1jol B: [34847]
        complexed with ca, cl, ffo
    13. Domain for 1jom:
    14. Domain for 1ra1:
    15. Domain for 1ra2:
    16. Domain for 1ra3:
    17. Domain for 1ra8:
    18. Domain for 1ra9:
    19. Domains for 1rb2:
      1. 2136935Domain d1rb2a_: 1rb2 A: [34863]
        complexed with fol, nap
      2. 2136936Domain d1rb2b_: 1rb2 B: [34864]
        complexed with fol, nap
    20. Domains for 1rb3:
      1. 2136937Domain d1rb3a_: 1rb3 A: [34861]
        complexed with mtx, nap
      2. 2136938Domain d1rb3b_: 1rb3 B: [34862]
        complexed with mtx, nap
    21. Domain for 1rc4:
    22. Domains for 1rd7:
      1. 2136949Domain d1rd7a_: 1rd7 A: [34871]
        complexed with bme, fol
      2. 2136950Domain d1rd7b_: 1rd7 B: [34872]
        complexed with bme, fol
    23. Domains for 1re7:
      1. 2136954Domain d1re7a_: 1re7 A: [34875]
        complexed with fol
      2. 2136955Domain d1re7b_: 1re7 B: [34876]
        complexed with fol
    24. Domain for 1rf7:
    25. Domain for 1rg7:
    26. Domain for 1rh3:
    27. Domain for 1rx1:
    28. Domain for 1rx2:
    29. Domain for 1rx3:
    30. Domain for 1rx4:
    31. Domain for 1rx5:
    32. Domain for 1rx6:
    33. Domain for 1rx7:
    34. Domain for 1rx8:
    35. Domain for 1rx9:
    36. Domains for 1tdr:
      1. 2136939Domain d1tdra_: 1tdr A: [34865]
        complexed with ca, cl, mtx, te
      2. 2136940Domain d1tdrb_: 1tdr B: [34866]
        complexed with ca, cl, mtx, te
    37. Domain for 2ano:
    38. Domain for 2anq:
    39. Domains for 2drc:
      1. 2136912Domain d2drca_: 2drc A: [34848]
        complexed with ca, cl, mtx
      2. 2136913Domain d2drcb_: 2drc B: [34849]
        complexed with ca, cl, mtx
    40. Domain for 3dau:
    41. Domains for 3drc:
      1. 2136906Domain d3drca_: 3drc A: [34840]
        complexed with ca, cl, mtx
      2. 2136907Domain d3drcb_: 3drc B: [34841]
        complexed with ca, cl, mtx
    42. Domain for 3kfy:
    43. Domains for 3och:
      1. 2136904Domain d3ocha_: 3och A: [182936]
        automated match to d1drea_
        complexed with 2mx, cl, mn
      2. 2136905Domain d3ochb_: 3och B: [182937]
        automated match to d1drea_
        complexed with 2mx, cl, mn
    44. Domain for 3ql0:
    45. Domain for 3ql3:
    46. Domains for 4dfr:
      1. 2136885Domain d4dfra_: 4dfr A: [34822]
        complexed with ca, cl, mtx
      2. 2136886Domain d4dfrb_: 4dfr B: [34823]
        complexed with ca, cl, mtx
    47. Domain for 4eig:
    48. Domains for 4eiz:
      1. 2136945Domain d4eiza_: 4eiz A: [196881]
        Other proteins in same PDB: d4eizc1, d4eizc2, d4eizd1, d4eizd2
        automated match to d3daua_
      2. 2136946Domain d4eizb_: 4eiz B: [227459]
        Other proteins in same PDB: d4eizc1, d4eizc2, d4eizd1, d4eizd2
        automated match to d1ddsa_
    49. Domains for 4ej1:
      1. 2136922Domain d4ej1a_: 4ej1 A: [227462]
        Other proteins in same PDB: d4ej1c1, d4ej1c2, d4ej1d1, d4ej1d2
        automated match to d1ddsa_
        complexed with fol, po4
      2. 2136923Domain d4ej1b_: 4ej1 B: [227461]
        Other proteins in same PDB: d4ej1c1, d4ej1c2, d4ej1d1, d4ej1d2
        automated match to d1ddsa_
        complexed with fol, po4
    50. Domain for 4fhb:
    51. Domains for 4gh8:
      1. 2136916Domain d4gh8a_: 4gh8 A: [197242]
        automated match to d3ql0a_
        complexed with ca, mtx, ndp
      2. 2136917Domain d4gh8b_: 4gh8 B: [197243]
        automated match to d3ql0a_
        complexed with ca, mtx, ndp
    52. Domain for 4i13:
    53. Domain for 4i1n:
    54. Domain for 4kjj:
    55. Domain for 4kjk:
    56. Domain for 4kjl:
    57. Domain for 4nx6:
    58. Domain for 4nx7:
    59. Domain for 4p3q:
    60. Domain for 4p3r:
    61. Domain for 4pdj:
    62. Domain for 4pss:
    63. Domain for 4pst:
    64. Domain for 4psy:
    65. Domain for 4psz:
    66. Domain for 4pth:
    67. Domain for 4ptj:
    68. Domains for 4qle:
      1. 2136873Domain d4qlea_: 4qle A: [261262]
        automated match to d3k74a_
        complexed with fol, nap; mutant
      2. 2136874Domain d4qleb_: 4qle B: [263728]
        automated match to d4qlea_
        complexed with fol, nap; mutant
    69. Domain for 4qlf:
    70. Domains for 4qlg:
      1. 2136883Domain d4qlga_: 4qlg A: [261260]
        automated match to d3k74a_
        complexed with fol, nap; mutant
      2. 2136884Domain d4qlgb_: 4qlg B: [261261]
        automated match to d3k74a_
        complexed with fol, nap; mutant
    71. Domain for 4rgc:
    72. Domain for 5cc9:
    73. Domain for 5ccc:
    74. Domain for 5dfr:
    75. Domains for 5e8q:
      1. 2279580Domain d5e8qa_: 5e8q A: [322881]
        automated match to d1ra9a_
        complexed with ca, cl, fol, ipa
      2. 2279599Domain d5e8qb_: 5e8q B: [322900]
        automated match to d1ra9a_
        complexed with ca, cl, fol, ipa
    76. Domains for 5eaj:
      1. 2279624Domain d5eajb_: 5eaj B: [322925]
        automated match to d1ra9a_
        complexed with ca, cl, fol
      2. 2279773Domain d5eaja_: 5eaj A: [323074]
        automated match to d1ra9a_
        complexed with ca, cl, fol
    77. Domain for 5w3q:
    78. Domain for 6dfr:
    79. Domain for 7dfr:
  4. 2136962Haloferax volcanii [TaxId:2246] [53604] (3 PDB entries)
    1. Domains for 1vdr:
      1. 2136963Domain d1vdra_: 1vdr A: [34893]
        CASP2
        complexed with po4
      2. 2136964Domain d1vdrb_: 1vdr B: [34894]
        CASP2
        complexed with po4
    2. Domain for 2ith:
    3. Domain for 2jyb:
  5. 2136967Lactobacillus casei [TaxId:1582] [53601] (10 PDB entries)
    1. Domain for 1ao8:
    2. Domain for 1bzf:
    3. Domain for 1dis:
    4. Domain for 1diu:
    5. Domain for 1lud:
    6. Domain for 2hm9:
    7. Domain for 2hqp:
    8. Domain for 2l28:
    9. Domain for 2lf1:
    10. Domain for 3dfr:
  6. 2136978Mycobacterium tuberculosis [TaxId:1773] [53602] (6 PDB entries)
    1. Domain for 1df7:
    2. Domain for 1dg5:
    3. Domain for 1dg7:
    4. Domain for 1dg8:
    5. Domain for 2cig:
    6. Domains for 5ja3:
      1. 2279321Domain d5ja3d_: 5ja3 D: [322622]
        automated match to d1df7a_
        complexed with ndp, u06
      2. 2279332Domain d5ja3a_: 5ja3 A: [322633]
        automated match to d1df7a_
        complexed with ndp, u06
      3. 2279339Domain d5ja3b_: 5ja3 B: [322640]
        automated match to d1df7a_
        complexed with ndp, u06
      4. 2279364Domain d5ja3c_: 5ja3 C: [322665]
        automated match to d1df7a_
        complexed with ndp, u06
  7. 2136984Staphylococcus aureus [TaxId:1280] [188976] (25 PDB entries)
    1. Domain for 3fra:
    2. Domain for 3frb:
    3. Domain for 3frd:
    4. Domain for 3fre:
    5. Domain for 3frf:
    6. Domain for 3fy8:
    7. Domain for 3fy9:
    8. Domain for 3fyv:
    9. Domain for 3fyw:
    10. Domain for 3m08:
    11. Domain for 3m09:
    12. Domain for 3sqy:
    13. Domain for 3sr5:
    14. Domain for 3srr:
    15. Domain for 3srs:
    16. Domain for 3srw:
    17. Domain for 4lae:
    18. Domain for 4lag:
    19. Domain for 4lah:
    20. Domain for 4lek:
    21. Domain for 4xe6:
    22. Domain for 4xec:
    23. Domain for 5hf0:
    24. Domain for 5hf2:
    25. Domain for 5jg0:
  8. 2137006Thermotoga maritima [TaxId:2336] [53603] (2 PDB entries)
    1. Domains for 1cz3:
      1. 2137009Domain d1cz3a_: 1cz3 A: [34891]
        complexed with so4
      2. 2137010Domain d1cz3b_: 1cz3 B: [34892]
        complexed with so4
    2. Domains for 1d1g:
      1. 2137007Domain d1d1ga_: 1d1g A: [34889]
        complexed with mtx, ndp
      2. 2137008Domain d1d1gb_: 1d1g B: [34890]
        complexed with mtx, ndp

More info for Protein Dihydrofolate reductase, prokaryotic type from c.71.1.1: Dihydrofolate reductases

Timeline for Protein Dihydrofolate reductase, prokaryotic type from c.71.1.1: Dihydrofolate reductases: