Lineage for d4q0ee2 (4q0e E:193-521)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2536167Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 2536168Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 2536169Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 2536170Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)
  7. 2536171Species Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)
  8. 2536181Domain d4q0ee2: 4q0e E:193-521 [260375]
    Other proteins in same PDB: d4q0ea1, d4q0eb1, d4q0ec1, d4q0ed1, d4q0ee1
    automated match to d1seja2
    complexed with 2xb, ndp, ufp

Details for d4q0ee2

PDB Entry: 4q0e (more details), 2.78 Å

PDB Description: crystal structure of ts-dhfr from cryptosporidium hominis in complex with nadph, fdump and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3- d]pyrimidine-methyl-phenyl-l-glutamic acid.
PDB Compounds: (E:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d4q0ee2:

Sequence; same for both SEQRES and ATOM records: (download)

>d4q0ee2 d.117.1.1 (E:193-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
lksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlenga
yrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekk
vyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlakli
etlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgsp
fniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrk
veniedfkwedieligyypyptikmdmav

SCOPe Domain Coordinates for d4q0ee2:

Click to download the PDB-style file with coordinates for d4q0ee2.
(The format of our PDB-style files is described here.)

Timeline for d4q0ee2: