PDB entry 3dga

View 3dga on RCSB PDB site
Description: Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP
Class: oxidoreductase, transferase
Keywords: Alpha-Beta, Methyltransferase, Oxidoreductase, Transferase
Deposited on 2008-06-13, released 2009-01-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3dgaa_
  • Chain 'B':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3dgab_
  • Chain 'C':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3dgac_
  • Chain 'D':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3dgad_
  • Heterogens: RJ1, NDP, UMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dgaA (A:)
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfca
vttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtswesipkkfkpls
nrinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklik
kiyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnnkmlneqnci
kgeeknndmplknddkdtchmkkltefyknvdkykinyen

    Sequence, based on observed residues (ATOM records): (download) 
    >3dgaA (A:)
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfca
vttyvneskyeklkykrckylnkekklqnvvvmgrtswesipkkfkplsnrinvilsrtl
kkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklikkiyftrinsty
ecdvffpeineneyqiisvsdvytsnnttldfiiykktn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3dgaB (B:)
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfca
vttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtswesipkkfkpls
nrinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklik
kiyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnnkmlneqnci
kgeeknndmplknddkdtchmkkltefyknvdkykinyen

    Sequence, based on observed residues (ATOM records): (download) 
    >3dgaB (B:)
meqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfcav
ttyvneskyeklkykrckylnketvdnskklqnvvvmgrtswesipkkfkplsnrinvil
srtlkkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklikkiyftri
nstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3dgaC (C:)
ddddeeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngn
kqsdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnkn
vriweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlknii
nlikndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpf
niasysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdi
kniedftisdftiqnyvhhekismdmaa

    Sequence, based on observed residues (ATOM records): (download) 
    >3dgaC (C:)
deeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngnkqs
drtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnknvri
weangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinli
kndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpfnia
sysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdikni
edftisdftiqnyvhhekismdmaa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3dgaD (D:)
ddddeeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngn
kqsdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnkn
vriweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlknii
nlikndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpf
niasysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdi
kniedftisdftiqnyvhhekismdmaa

    Sequence, based on observed residues (ATOM records): (download) 
    >3dgaD (D:)
ddddeeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngn
kqsdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnkn
vriweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlknii
nlikndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpf
niasysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdi
kniedftisdftiqnyvhhekismdm