SCOPe 2.08: Domain d4q0ed2: 4q0e D:193-521

Lineage for d4q0ed2 (4q0e D:193-521)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [100887] (16 PDB entries)

8. Domain d4q0ed2: 4q0e D:193-521 [260377]
   Other proteins in same PDB: d4q0ea1, d4q0eb1, d4q0ec1, d4q0ed1, d4q0ee1
   automated match to d1seja2
   complexed with 2xb, ndp, ufp

Details for d4q0ed2

PDB Entry: 4q0e, 2.78 Å

PDB Description: crystal structure of ts-dhfr from cryptosporidium hominis in complex with nadph, fdump and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3- d]pyrimidine-methyl-phenyl-l-glutamic acid.

PDB Compounds: (D:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d4q0ed2:

Sequence; same for both SEQRES and ATOM records:

>d4q0ed2 d.117.1.1 (D:193-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
lksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlenga
yrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekk
vyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlakli
etlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgsp
fniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrk
veniedfkwedieligyypyptikmdmav

Timeline for d4q0ed2:

• d4q0ed2 first appeared in SCOPe 2.04
  
• d4q0ed2 appears in SCOPe 2.07