Lineage for Protein: Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2536167Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 2536168Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 2536169Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 2536170Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

Species:

  1. 2536171Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)
    1. Domains for 1qzf:
      1. 2536172Domain d1qzfa2: 1qzf A:181-521 [96634]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
      2. 2536173Domain d1qzfb2: 1qzf B:181-521 [96636]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
      3. 2536174Domain d1qzfc2: 1qzf C:181-521 [96638]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
      4. 2536175Domain d1qzfd2: 1qzf D:181-521 [96640]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
      5. 2536176Domain d1qzfe2: 1qzf E:181-521 [96642]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
    2. Domains for 1sej:
      1. 2536182Domain d1seja2: 1sej A:181-521 [105456]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
      2. 2536183Domain d1sejb2: 1sej B:181-521 [105458]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
      3. 2536184Domain d1sejc2: 1sej C:181-521 [105460]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
      4. 2536185Domain d1sejd2: 1sej D:181-521 [105462]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
      5. 2536186Domain d1seje2: 1sej E:181-521 [105464]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
    3. Domains for 4ky8:
      1. 2536187Domain d4ky8a2: 4ky8 A:193-521 [253461]
        Other proteins in same PDB: d4ky8a1, d4ky8b1, d4ky8c1, d4ky8d1, d4ky8e1
        automated match to d1qzfa2
        complexed with 1uf, mtx, ndp, ufp
      2. 2536188Domain d4ky8b2: 4ky8 B:193-521 [253463]
        Other proteins in same PDB: d4ky8a1, d4ky8b1, d4ky8c1, d4ky8d1, d4ky8e1
        automated match to d1qzfa2
        complexed with 1uf, mtx, ndp, ufp
      3. 2536189Domain d4ky8c2: 4ky8 C:193-521 [253465]
        Other proteins in same PDB: d4ky8a1, d4ky8b1, d4ky8c1, d4ky8d1, d4ky8e1
        automated match to d1qzfa2
        complexed with 1uf, mtx, ndp, ufp
      4. 2536190Domain d4ky8d2: 4ky8 D:193-521 [253467]
        Other proteins in same PDB: d4ky8a1, d4ky8b1, d4ky8c1, d4ky8d1, d4ky8e1
        automated match to d1qzfa2
        complexed with 1uf, mtx, ndp, ufp
      5. 2536191Domain d4ky8e2: 4ky8 E:193-521 [253469]
        Other proteins in same PDB: d4ky8a1, d4ky8b1, d4ky8c1, d4ky8d1, d4ky8e1
        automated match to d1qzfa2
        complexed with 1uf, mtx, ndp, ufp
    4. Domains for 4q0e:
      1. 2536177Domain d4q0ea2: 4q0e A:193-521 [260371]
        Other proteins in same PDB: d4q0ea1, d4q0eb1, d4q0ec1, d4q0ed1, d4q0ee1
        automated match to d1seja2
        complexed with 2xb, ndp, ufp
      2. 2536178Domain d4q0eb2: 4q0e B:193-521 [260369]
        Other proteins in same PDB: d4q0ea1, d4q0eb1, d4q0ec1, d4q0ed1, d4q0ee1
        automated match to d1seja2
        complexed with 2xb, ndp, ufp
      3. 2536179Domain d4q0ec2: 4q0e C:193-521 [260373]
        Other proteins in same PDB: d4q0ea1, d4q0eb1, d4q0ec1, d4q0ed1, d4q0ee1
        automated match to d1seja2
        complexed with 2xb, ndp, ufp
      4. 2536180Domain d4q0ed2: 4q0e D:193-521 [260377]
        Other proteins in same PDB: d4q0ea1, d4q0eb1, d4q0ec1, d4q0ed1, d4q0ee1
        automated match to d1seja2
        complexed with 2xb, ndp, ufp
      5. 2536181Domain d4q0ee2: 4q0e E:193-521 [260375]
        Other proteins in same PDB: d4q0ea1, d4q0eb1, d4q0ec1, d4q0ed1, d4q0ee1
        automated match to d1seja2
        complexed with 2xb, ndp, ufp
  2. 2536192Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88964] (3 PDB entries)
    1. Domains for 1j3i:
      1. 2536195Domain d1j3ic_: 1j3i C: [84064]
        Other proteins in same PDB: d1j3ia_, d1j3ib_
        complexed with ndp, ump, wra
      2. 2536196Domain d1j3id_: 1j3i D: [84065]
        Other proteins in same PDB: d1j3ia_, d1j3ib_
        complexed with ndp, ump, wra
    2. Domains for 1j3j:
      1. 2536197Domain d1j3jc_: 1j3j C: [84068]
        Other proteins in same PDB: d1j3ja_, d1j3jb_
        complexed with cp6, ndp, ump; mutant
      2. 2536198Domain d1j3jd_: 1j3j D: [84069]
        Other proteins in same PDB: d1j3ja_, d1j3jb_
        complexed with cp6, ndp, ump; mutant
    3. Domains for 1j3k:
      1. 2536193Domain d1j3kc_: 1j3k C: [84072]
        Other proteins in same PDB: d1j3ka_, d1j3kb_
        complexed with ndp, ump, wra; mutant
      2. 2536194Domain d1j3kd_: 1j3k D: [84073]
        Other proteins in same PDB: d1j3ka_, d1j3kb_
        complexed with ndp, ump, wra; mutant

More info for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

Timeline for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase: