Lineage for Protein: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2413227Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2420459Superfamily c.1.10: Aldolase [51569] (9 families) (S)
    Common fold covers whole protein structure
  5. 2421381Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51594] (2 protein domains)
    hybrid of classes I and II aldolase
    automatically mapped to Pfam PF00490
  6. 2421382Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51595] (5 species)

Species:

  1. 2421383Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51596] (12 PDB entries)
    1. Domain for 1aw5:
    2. Domain for 1eb3:
    3. Domain for 1gjp:
    4. Domain for 1h7n:
    5. Domain for 1h7o:
    6. Domain for 1h7p:
    7. Domain for 1h7r:
    8. Domain for 1ohl:
    9. Domain for 1qmk:
    10. Domain for 1qml:
    11. Domain for 1qnv:
    12. Domain for 1ylv:
  2. 2421396Escherichia coli [TaxId:562] [51598] (4 PDB entries)
    1. Domain for 1b4e:
    2. Domains for 1i8j:
      1. 2421401Domain d1i8ja_: 1i8j A: [61968]
        complexed with dsb, mg, zn
      2. 2421402Domain d1i8jb_: 1i8j B: [61969]
        complexed with dsb, mg, zn
    3. Domains for 1l6s:
      1. 2421397Domain d1l6sa_: 1l6s A: [73627]
        complexed with dsb, mg, zn
      2. 2421398Domain d1l6sb_: 1l6s B: [73628]
        complexed with dsb, mg, zn
    4. Domains for 1l6y:
      1. 2421399Domain d1l6ya_: 1l6y A: [73645]
        complexed with 4ox, gol, mg, zn
      2. 2421400Domain d1l6yb_: 1l6y B: [73646]
        complexed with 4ox, gol, mg, zn
  3. 2421404Human (Homo sapiens) [TaxId:9606] [63921] (4 PDB entries)
    1. Domains for 1e51:
      1. 2421407Domain d1e51a_: 1e51 A: [59254]
        complexed with pbg, so4, zn
      2. 2421408Domain d1e51b_: 1e51 B: [59255]
        complexed with pbg, so4, zn
    2. Domains for 1pv8:
      1. 2421405Domain d1pv8a_: 1pv8 A: [95155]
        complexed with pb1, zn; mutant
      2. 2421406Domain d1pv8b_: 1pv8 B: [95156]
        complexed with pb1, zn; mutant
    3. Domains for 5hms:
      1. 2421409Domain d5hmsa_: 5hms A: [314757]
        automated match to d1e51a_
        complexed with zn
      2. 2421410Domain d5hmsb_: 5hms B: [314758]
        automated match to d1e51a_
        complexed with zn
    4. Domains for 5hnr:
      1. 2421411Domain d5hnra_: 5hnr A: [314831]
        automated match to d1e51a_
        complexed with dav, so4, zn
      2. 2421412Domain d5hnrb_: 5hnr B: [314803]
        automated match to d1e51a_
        complexed with dav, so4, zn
  4. 2421413Prosthecochloris vibrioformis [TaxId:1098] [110362] (2 PDB entries)
    Uniprot Q59334
    1. Domains for 1w1z:
      1. 2421416Domain d1w1za_: 1w1z A: [109081]
        complexed with mg, shf
      2. 2421417Domain d1w1zb_: 1w1z B: [109082]
        complexed with mg, shf
    2. Domains for 2c1h:
      1. 2421414Domain d2c1ha_: 2c1h A: [129634]
        automated match to d1w1za_
        complexed with dsb, mg
      2. 2421415Domain d2c1hb_: 2c1h B: [129635]
        automated match to d1w1za_
        complexed with dsb, mg
  5. 2421418Pseudomonas aeruginosa [TaxId:287] [51597] (2 PDB entries)
    1. Domains for 1b4k:
      1. 2421421Domain d1b4ka_: 1b4k A: [29184]
        complexed with mg, shf, so4
      2. 2421422Domain d1b4kb_: 1b4k B: [29185]
        complexed with mg, shf, so4
    2. Domains for 1gzg:
      1. 2421419Domain d1gzga_: 1gzg A: [70805]
        complexed with k, laf, mg, na, so4; mutant
      2. 2421420Domain d1gzgb_: 1gzg B: [70806]
        complexed with k, laf, mg, na, so4; mutant

More info for Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

Timeline for Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase):

  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) first appeared (with stable ids) in SCOP 1.55
  • Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) from c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) appears in SCOPe 2.06