Lineage for Protein: High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2014835Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 2014836Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families) (S)
  5. 2014926Family a.211.1.2: PDEase [48548] (7 protein domains)
    Pfam PF00233; multihelical; can be divided into three subdomains
  6. 2015146Protein High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A [109942] (2 species)

Species:

  1. 2015147Chimpanzee (Pan troglodytes) [TaxId:9598] [261550] (1 PDB entry)
  2. 2015150Human (Homo sapiens) [TaxId:9606] [109943] (20 PDB entries)
    Uniprot O76083 241-566
    1. Domains for 1tbm:
      1. 2015161Domain d1tbma_: 1tbm A: [303079]
        automated match to d2hd1a_
        complexed with ibm, mg, zn
      2. 2015162Domain d1tbmb_: 1tbm B: [303080]
        automated match to d2hd1a_
        complexed with ibm, mg, zn
    2. Domains for 2hd1:
      1. 2015159Domain d2hd1a_: 2hd1 A: [136338]
        automated match to d1tbma_
        complexed with ibm, mg, zn
      2. 2015160Domain d2hd1b_: 2hd1 B: [136339]
        automated match to d1tbma_
        complexed with ibm, mg, zn
    3. Domains for 3dy8:
      1. 2015151Domain d3dy8a2: 3dy8 A:182-505 [157937]
        Other proteins in same PDB: d3dy8a3, d3dy8b3
        automated match to d2hd1a1
        complexed with 5gp, fmt, ibm, mg, mn
      2. 2015152Domain d3dy8b2: 3dy8 B:182-505 [157938]
        Other proteins in same PDB: d3dy8a3, d3dy8b3
        automated match to d2hd1a1
        complexed with 5gp, fmt, ibm, mg, mn
    4. Domains for 3dyl:
      1. 2015173Domain d3dyla2: 3dyl A:182-505 [157940]
        Other proteins in same PDB: d3dyla3, d3dylb3
        automated match to d2hd1a1
        complexed with fmt, ibm, mg, mn, pcg
      2. 2015174Domain d3dylb2: 3dyl B:182-505 [157941]
        Other proteins in same PDB: d3dyla3, d3dylb3
        automated match to d2hd1a1
        complexed with fmt, ibm, mg, mn, pcg
    5. Domains for 3dyn:
      1. 2015153Domain d3dyna2: 3dyn A:182-505 [157942]
        Other proteins in same PDB: d3dyna3, d3dynb3
        automated match to d2hd1a1
        complexed with ibm, mg, pcg, zn
      2. 2015154Domain d3dynb2: 3dyn B:182-505 [157943]
        Other proteins in same PDB: d3dyna3, d3dynb3
        automated match to d2hd1a1
        complexed with ibm, mg, pcg, zn
    6. Domains for 3dyq:
      1. 2015167Domain d3dyqa2: 3dyq A:182-505 [157944]
        Other proteins in same PDB: d3dyqa3, d3dyqb3
        automated match to d2hd1a1
        complexed with ibm, na, pcg
      2. 2015168Domain d3dyqb2: 3dyq B:182-505 [157945]
        Other proteins in same PDB: d3dyqa3, d3dyqb3
        automated match to d2hd1a1
        complexed with ibm, na, pcg
    7. Domains for 3dys:
      1. 2015155Domain d3dysa_: 3dys A: [157946]
        Other proteins in same PDB: d3dysb3
        automated match to d2hd1a1
        complexed with 5gp, fmt, ibm, mg, mn
      2. 2015156Domain d3dysb2: 3dys B:182-505 [157947]
        Other proteins in same PDB: d3dysb3
        automated match to d2hd1a1
        complexed with 5gp, fmt, ibm, mg, mn
    8. Domains for 3jsi:
      1. 2015177Domain d3jsia1: 3jsi A:182-505 [178785]
        Other proteins in same PDB: d3jsia2, d3jsib2
        automated match to d2hd1a1
        complexed with mg, wtc, zn
      2. 2015178Domain d3jsib1: 3jsi B:182-505 [178786]
        Other proteins in same PDB: d3jsia2, d3jsib2
        automated match to d2hd1a1
        complexed with mg, wtc, zn
    9. Domains for 3jsw:
      1. 2015157Domain d3jswa1: 3jsw A:182-505 [178795]
        Other proteins in same PDB: d3jswa2, d3jswb2
        automated match to d2hd1a1
        complexed with jar, mg, zn
      2. 2015158Domain d3jswb1: 3jsw B:182-505 [178796]
        Other proteins in same PDB: d3jswa2, d3jswb2
        automated match to d2hd1a1
        complexed with jar, mg, zn
    10. Domains for 3k3e:
      1. 2015185Domain d3k3ea_: 3k3e A: [179038]
        automated match to d2hd1a1
        complexed with mg, pdb, zn
      2. 2015186Domain d3k3eb_: 3k3e B: [179039]
        automated match to d2hd1a1
        complexed with mg, pdb, zn
    11. Domains for 3k3h:
      1. 2015183Domain d3k3ha_: 3k3h A: [179040]
        automated match to d2hd1a1
        complexed with bye, mg, zn
      2. 2015184Domain d3k3hb_: 3k3h B: [179041]
        automated match to d2hd1a1
        complexed with bye, mg, zn
    12. Domains for 3n3z:
      1. 2015175Domain d3n3za_: 3n3z A: [181882]
        automated match to d2hd1a1
        complexed with cl, ibm, mg, zn; mutant
      2. 2015176Domain d3n3zb_: 3n3z B: [181883]
        automated match to d2hd1a1
        complexed with cl, ibm, mg, zn; mutant
    13. Domains for 3qi4:
      1. 2015169Domain d3qi4a_: 3qi4 A: [248900]
        automated match to d2hd1a_
        complexed with ibm, mg, zn
      2. 2015170Domain d3qi4b_: 3qi4 B: [248901]
        automated match to d2hd1a_
        complexed with ibm, mg, zn
    14. Domains for 4e90:
      1. 2015165Domain d4e90a1: 4e90 A:182-505 [193959]
        Other proteins in same PDB: d4e90a2, d4e90b2
        automated match to d3dy8a_
        complexed with 7rg, mg, zn
      2. 2015166Domain d4e90b1: 4e90 B:182-505 [193958]
        Other proteins in same PDB: d4e90a2, d4e90b2
        automated match to d3dy8a_
        complexed with 7rg, mg, zn
    15. Domains for 4g2j:
      1. 2015163Domain d4g2ja1: 4g2j A:182-505 [197157]
        Other proteins in same PDB: d4g2ja2, d4g2jb2
        automated match to d3dy8a_
        complexed with 0wf, mg, zn
      2. 2015164Domain d4g2jb1: 4g2j B:182-505 [197159]
        Other proteins in same PDB: d4g2ja2, d4g2jb2
        automated match to d3dy8a_
        complexed with 0wf, mg, zn
    16. Domains for 4g2l:
      1. 2015181Domain d4g2la1: 4g2l A:182-505 [252131]
        Other proteins in same PDB: d4g2la2, d4g2lb2
        automated match to d3dy8a_
        complexed with 0wl, mg, zn
      2. 2015182Domain d4g2lb1: 4g2l B:182-505 [252132]
        Other proteins in same PDB: d4g2la2, d4g2lb2
        automated match to d3dy8a_
        complexed with 0wl, mg, zn
    17. Domains for 4gh6:
      1. 2015179Domain d4gh6a_: 4gh6 A: [194598]
        automated match to d2hd1a_
        complexed with luo, mg, zn
      2. 2015180Domain d4gh6b_: 4gh6 B: [194597]
        automated match to d2hd1a_
        complexed with luo, mg, zn
    18. Domains for 4y86:
      1. 2015171Domain d4y86a_: 4y86 A: [277032]
        automated match to d2hd1a_
        complexed with 49d, 49e, mg, zn
      2. 2015172Domain d4y86b_: 4y86 B: [277033]
        automated match to d2hd1a_
        complexed with 49d, 49e, mg, zn
    19. Domains for 4y87:
      1. 2015189Domain d4y87a_: 4y87 A: [277031]
        automated match to d2hd1a_
        complexed with 49e, mg, zn
      2. 2015190Domain d4y87b_: 4y87 B: [277029]
        automated match to d2hd1a_
        complexed with 49e, mg, zn
    20. Domains for 4y8c:
      1. 2015187Domain d4y8ca_: 4y8c A: [277034]
        automated match to d2hd1a_
        complexed with 49d, mg, zn
      2. 2015188Domain d4y8cb_: 4y8c B: [277030]
        automated match to d2hd1a_
        complexed with 49d, mg, zn

More info for Protein High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A from a.211.1.2: PDEase

Timeline for Protein High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A from a.211.1.2: PDEase:

  • Protein High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A from a.211.1.2: PDEase first appeared in SCOP 1.69
  • Protein High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A from a.211.1.2: PDEase appears in SCOPe 2.05