PDB entry 3k3e

View 3k3e on RCSB PDB site
Description: Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691
Class: hydrolase
Keywords: PDE9, catalytic domain, cGMP, Hydrolase, Manganese, Metal-binding, Phosphoprotein
Deposited on 2009-10-02, released 2010-02-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-11-13, with a file datestamp of 2013-11-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.23
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE9A, PDE9A2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3k3ea_
  • Chain 'B':
    Compound: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE9A, PDE9A2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3k3eb_
  • Heterogens: ZN, MG, PDB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3k3eA (A:)
ptypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlf
cvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgyn
ntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitli
latdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdcl
leeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeiml
qplwesrdryeelkriddamkelqkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3k3eA (A:)
llspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlfcvhdny
rnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgynntyqin
artelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitlilatdma
rhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdclleeyfm
qsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeimlqplwes
rdryeelkriddamkelqkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3k3eB (B:)
ptypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlf
cvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgyn
ntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitli
latdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdcl
leeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeiml
qplwesrdryeelkriddamkelqkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3k3eB (B:)
llspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlfcvhdny
rnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgynntyqin
artelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitlilatdma
rhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdclleeyfm
qsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeimlqplwes
rdryeelkriddamkelqkk