PDB entry 3k3h

View 3k3h on RCSB PDB site
Description: Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691
Class: hydrolase
Keywords: PDE9, catalytic domain, cGMP, Hydrolase, Manganese, Metal-binding, Phosphoprotein
Deposited on 2009-10-02, released 2010-02-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-11-13, with a file datestamp of 2013-11-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.223
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE9A, PDE9A2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3k3ha_
  • Chain 'B':
    Compound: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE9A, PDE9A2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3k3hb_
  • Heterogens: ZN, MG, BYE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3k3hA (A:)
    ptypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlf
    cvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgyn
    ntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitli
    latdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdcl
    leeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeiml
    qplwesrdryeelkriddamkelqkk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3k3hA (A:)
    yllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlfcvhdn
    yrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgynntyqi
    nartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitlilatdm
    arhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdclleeyf
    mqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeimlqplwe
    srdryeelkriddamkelqkk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3k3hB (B:)
    ptypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlf
    cvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgyn
    ntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitli
    latdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdcl
    leeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeiml
    qplwesrdryeelkriddamkelqkk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3k3hB (B:)
    yllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlfcvhdn
    yrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgynntyqi
    nartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitlilatdm
    arhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdclleeyf
    mqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeimlqplwe
    srdryeelkriddamkelqkk