Lineage for Family c.1.8.1: Amylase, catalytic domain

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. Superfamily c.1.8: (Trans)glycosidases [51445] (15 families) (S)
  5. Family c.1.8.1: Amylase, catalytic domain [51446] (26 proteins)
    members of the family may contain various insert subdomains
    in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain

Proteins:

  1. 1,4-alpha-glucan branching enzyme, central domain [82244] (1 species)
  2. 4-alpha-glucanotransferase [75062] (1 species)
  3. A4 beta-galactosidase [82246] (1 species)
    the catalytic domain is very similar to that of the bacterial beta-amylase; but contains a typical alpha-amylase extra domain
  4. Amylomaltase MalQ [51478] (3 species)
    4-alpha-glucanotransferase; single-domain amylase with several insertions in the common fold
    1. Species Aquifex aeolicus [TaxId:63363] [141770] (1 PDB entry)
      Uniprot O66937 1-485
    2. Species Potato (Solanum tuberosum) [TaxId:4113] [141771] (4 PDB entries)
      Uniprot Q06801 54-576
    3. Species Thermus aquaticus [TaxId:271] [51479] (4 PDB entries)
      synonym: Thermus thermophilus
  5. Amylosucrase [69384] (1 species)
  6. Animal alpha-amylase [51458] (3 species)
    contains Ca2+-binding subdomain, residues 100-170
    1. Species Human (Homo sapiens) [TaxId:9606] [51460] (55 PDB entries)
      Uniprot P04746 16-511 ! SQ 04746
    2. Species Pig (Sus scrofa) [TaxId:9823] [51459] (13 PDB entries)
    3. Species Yellow mealworm (Tenebrio molitor), larva [TaxId:7067] [51461] (4 PDB entries)
  7. Bacterial alpha-amylase [51447] (10 species)
    1. Species Bacillus halmapalus [TaxId:79882] [141768] (1 PDB entry)
      Uniprot P19571 38-431
    2. Species Bacillus licheniformis [TaxId:1402] [51448] (9 PDB entries)
    3. Species Bacillus sp. 707 [TaxId:1416] [117366] (4 PDB entries)
      Uniprot P19571 38-518
    4. Species Bacillus sp., ksm-k38 [TaxId:1409] [89463] (6 PDB entries)
    5. Species Bacillus stearothermophilus [TaxId:1422] [51451] (1 PDB entry)
    6. Species Bacillus subtilis [TaxId:1423] [51450] (2 PDB entries)
      Uniprot P00691
    7. Species Chimera (Bacillus amyloliquefaciens) and (Bacillus licheniformis) [TaxId:1390] [63903] (4 PDB entries)
      the N-terminal 300 residues are from B. amyloliquefaciens
    8. Species Halothermothrix orenii [TaxId:31909] [141767] (1 PDB entry)
      Uniprot Q8GPL8 28-436
    9. Species Pseudoalteromonas haloplanktis [TaxId:228] [51449] (9 PDB entries)
    10. Species Pyrococcus woesei [TaxId:2262] [89464] (3 PDB entries)
  8. Bacterial beta-amylase [51485] (1 species)
    protein contains additional starch-binding domain
  9. beta-Amylase [51481] (3 species)
    Common fold covers whole protein structure
    1. Species Barley (Hordeum vulgare) [TaxId:4513] [51483] (1 PDB entry)
    2. Species Soybean (Glycine max) [TaxId:3847] [51482] (18 PDB entries)
      Uniprot P10538
    3. Species Sweet potato (Ipomoea batatas) [TaxId:4120] [51484] (3 PDB entries)
  10. Cyclodextrin glycosyltransferase [51452] (5 species)
    contains two more all-beta domains, one is Immunoglobulin-like and the other is trasthyretin-like
    1. Species Bacillus circulans, different strains [TaxId:1397] [51453] (36 PDB entries)
    2. Species Bacillus sp. 1011, alkaliphilic [TaxId:1410] [51456] (8 PDB entries)
      Uniprot P05618
    3. Species Bacillus stearothermophilus [TaxId:1422] [51454] (1 PDB entry)
    4. Species Bacillus stearothermophilus, maltogenic alpha-amylase [TaxId:1422] [51455] (2 PDB entries)
    5. Species Thermoanaerobacterium thermosulfurigenes, EM1 [TaxId:33950] [51457] (4 PDB entries)
  11. Cyclomaltodextrinase, central domain [102058] (1 species)
    protein shares similar domain organization with maltogenic amylases but differs in the spatial arrangement of its domains
  12. Fungal alpha-amylases [51462] (2 species)
    1. Species Aspergillus niger, acid amylase [TaxId:5061] [51463] (1 PDB entry)
    2. Species Aspergillus oryzae, Taka-amylase [TaxId:5062] [51464] (8 PDB entries)
  13. G4-amylase (1,4-alpha-D-glucan maltotetrahydrolase) [51472] (1 species)
  14. Glycosyltrehalose trehalohydrolase, central domain [51468] (2 species)
    contains an additional N-terminal domain
    1. Species Deinococcus radiodurans [TaxId:1299] [141769] (9 PDB entries)
      Uniprot Q9RX51 111-528
    2. Species Sulfolobus solfataricus, km1 [TaxId:2287] [51469] (8 PDB entries)
  15. Isoamylase, central domain [51470] (1 species)
  16. Isomaltulose synthase PalI [89466] (2 species)
    1. Species Erwinia rhapontici [TaxId:55212] [254869] (5 PDB entries)
    2. Species Klebsiella sp., lx3 [TaxId:576] [89467] (1 PDB entry)
  17. Maltogenic amylase, central domain [51465] (4 species)
    contains an additional N-terminal domain
    1. Species Bacillus sp., cyclomaltodextrinase [TaxId:1409] [75060] (1 PDB entry)
    2. Species Thermoactinomyces vulgaris, TVAI [TaxId:2026] [75061] (8 PDB entries)
    3. Species Thermoactinomyces vulgaris, TVAII [TaxId:2026] [51467] (12 PDB entries)
    4. Species Thermus sp. [TaxId:275] [51466] (2 PDB entries)
  18. Maltooligosyl trehalose synthase [82242] (1 species)
    elaborated with several large insertions in the common fold
  19. Maltosyltransferase [63904] (1 species)
    similar to bacterial alpha-amylase; contains larger insertion domain
  20. Melibiase [75064] (4 species)
    1. Species Chicken (Gallus gallus) [TaxId:9031] [75065] (2 PDB entries)
      alpha-N-acetylgalactosaminidase
    2. Species Human (Homo sapiens) [TaxId:9606] [102062] (21 PDB entries)
      alpha-galactosidase A
    3. Species Rice (Oryza sativa) [TaxId:4530] [89468] (1 PDB entry)
      alpha-galactosidase
    4. Species Trichoderma reesei [TaxId:51453] [110349] (2 PDB entries)
      Alpha-galactosidase agl1
      Uniprot Q92456
  21. Neopullulanase, central domain [82240] (1 species)
    homologous to Maltogenic amylase
  22. Oligo-1,6, glucosidase [51476] (1 species)
  23. Plant alpha-amylase [51474] (2 species)
    1. Species Barley (Hordeum vulgare), AMY1 isozyme [TaxId:4513] [89465] (7 PDB entries)
    2. Species Barley (Hordeum vulgare), seeds, AMY2 isozyme [TaxId:4513] [51475] (3 PDB entries)
  24. Pullulanase PulA [159381] (1 species)
  25. Sucrose phosphorylase [102060] (1 species)
    sequence and close structural relationship to amylosucrase; variations in the C-terminal domain fold
  26. automated matches [190099] (31 species)
    not a true protein
    1. Species Fungus (Aspergillus oryzae) [TaxId:5062] [393398] (1 PDB entry)
    2. Species Bacillus cereus [TaxId:1396] [254917] (3 PDB entries)
    3. Species Bacillus halmapalus [TaxId:79882] [255187] (2 PDB entries)
    4. Species Bacillus sp. [225222] (1 PDB entry)
    5. Species Bacillus sp. [TaxId:535911] [225472] (1 PDB entry)
    6. Species Bacillus subtilis [TaxId:224308] [228099] (5 PDB entries)
    7. Species Barley (Hordeum vulgare) [TaxId:4513] [255684] (11 PDB entries)
    8. Species Bifidobacterium adolescentis [TaxId:1680] [255183] (4 PDB entries)
    9. Species Bifidobacterium adolescentis [TaxId:367928] [365787] (1 PDB entry)
    10. Species Escherichia coli [TaxId:331111] [311496] (3 PDB entries)
    11. Species Escherichia coli [TaxId:562] [270950] (4 PDB entries)
    12. Species Geobacillus stearothermophilus [TaxId:1422] [311444] (1 PDB entry)
    13. Species Human (Homo sapiens) [TaxId:9606] [225770] (14 PDB entries)
    14. Species Klebsiella pneumoniae [TaxId:573] [359376] (10 PDB entries)
    15. Species Listeria monocytogenes [TaxId:169963] [277525] (1 PDB entry)
    16. Species Neisseria polysaccharea [TaxId:489] [226280] (7 PDB entries)
    17. Species Nicotiana benthamiana [TaxId:4100] [351546] (1 PDB entry)
    18. Species Oryzias latipes [TaxId:8090] [226401] (1 PDB entry)
    19. Species Pelomonas saccharophila [TaxId:304] [377973] (4 PDB entries)
    20. Species Pig (Sus scrofa) [TaxId:9823] [225875] (3 PDB entries)
    21. Species Protaminobacter rubrum [TaxId:126825] [225680] (2 PDB entries)
    22. Species Pseudomonas mesoacidophila [TaxId:265293] [224875] (9 PDB entries)
    23. Species Pyrococcus woesei [TaxId:2262] [226292] (1 PDB entry)
    24. Species Soybean (Glycine max) [TaxId:3847] [186821] (2 PDB entries)
    25. Species Streptococcus agalactiae [TaxId:1311] [402353] (1 PDB entry)
    26. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [278910] (6 PDB entries)
    27. Species Thermoactinomyces vulgaris [TaxId:2026] [254920] (8 PDB entries)
    28. Species Thermus aquaticus [TaxId:271] [328921] (1 PDB entry)
    29. Species Thermus brockianus [TaxId:56956] [189542] (1 PDB entry)
    30. Species Thermus thermophilus [TaxId:274] [188525] (3 PDB entries)
    31. Species Wheat (Triticum aestivum) [TaxId:4565] [361430] (1 PDB entry)

More info for Family c.1.8.1: Amylase, catalytic domain

Timeline for Family c.1.8.1: Amylase, catalytic domain: