Class b: All beta proteins [48724] (174 folds) |
Fold b.50: Acid proteases [50629] (1 superfamily) barrel, closed; n=6, S=10, complex topology |
Superfamily b.50.1: Acid proteases [50630] (4 families) |
Family b.50.1.2: Pepsin-like [50646] (11 proteins) duplication: consists of two similar barrel domains N-terminal: barrel, partly opened; n*=6, S*=10 |
Protein beta-secretase (memapsin) [50671] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50672] (117 PDB entries) Uniprot P56817 58-446 ! Uniprot P56817 60-447 |
Domain d1fkna_: 1fkn A: [26879] |
Domain d1fknb_: 1fkn B: [26880] |
Domain d1m4ha_: 1m4h A: [74455] |
Domain d1m4hb_: 1m4h B: [74456] |
Domain d1sgza_: 1sgz A: [98872] |
Domain d1sgzb_: 1sgz B: [98873] |
Domain d1sgzc_: 1sgz C: [98874] |
Domain d1sgzd_: 1sgz D: [98875] |
Domain d1tqfa_: 1tqf A: [112613] complexed with 32p |
Domain d1w50a_: 1w50 A: [109173] complexed with iod |
Domain d1w51a_: 1w51 A: [109174] complexed with iod, l01 |
Domain d1xn2a_: 1xn2 A: [122178] automated match to d1fkna_ |
Domain d1xn2b_: 1xn2 B: [122179] automated match to d1fkna_ |
Domain d1xn2c_: 1xn2 C: [122180] automated match to d1fkna_ |
Domain d1xn2d_: 1xn2 D: [122181] automated match to d1fkna_ |
Domain d1xn3a_: 1xn3 A: [122182] automated match to d1fkna_ |
Domain d1xn3b_: 1xn3 B: [122183] automated match to d1fkna_ |
Domain d1xn3c_: 1xn3 C: [122184] automated match to d1fkna_ |
Domain d1xn3d_: 1xn3 D: [122185] automated match to d1fkna_ |
Domain d1xs7d_: 1xs7 D: [115919] complexed with mmi |
Domain d2b8la_: 2b8l A: [163006] automated match to d1fkna_ complexed with 5ha |
Domain d2b8va_: 2b8v A: [163007] automated match to d1fkna_ complexed with 3bn |
Domain d2f3ea_: 2f3e A: [132864] automated match to d1fkna_ complexed with axq |
Domain d2f3eb_: 2f3e B: [132865] automated match to d1fkna_ complexed with axq |
Domain d2f3ec_: 2f3e C: [132866] automated match to d1fkna_ complexed with axq |
Domain d2f3fa_: 2f3f A: [132867] automated match to d1fkna_ complexed with axf |
Domain d2f3fb_: 2f3f B: [132868] automated match to d1fkna_ complexed with axf |
Domain d2f3fc_: 2f3f C: [132869] automated match to d1fkna_ complexed with axf |
Domain d2fdpa_: 2fdp A: [133316] automated match to d1fkna_ complexed with frp |
Domain d2fdpb_: 2fdp B: [133317] automated match to d1fkna_ complexed with frp |
Domain d2fdpc_: 2fdp C: [133318] automated match to d1fkna_ complexed with frp |
Domain d2g94a_: 2g94 A: [134790] automated match to d1fkna_ complexed with zpq |
Domain d2g94b_: 2g94 B: [134791] automated match to d1fkna_ complexed with zpq |
Domain d2g94c_: 2g94 C: [134792] automated match to d1fkna_ complexed with zpq |
Domain d2g94d_: 2g94 D: [134793] automated match to d1fkna_ complexed with zpq |
Domain d2hiza1: 2hiz A:61P-385 [136533] automatically matched to d1fkna_ complexed with lij, po4 |
Domain d2hizb1: 2hiz B:61P-385 [136534] automatically matched to d1fkna_ complexed with lij, po4 |
Domain d2hizc1: 2hiz C:61P-385 [136535] automatically matched to d1fkna_ complexed with lij, po4 |
Domain d2hm1a_: 2hm1 A: [136571] automated match to d1fkna_ complexed with liq |
Domain d2iqga_: 2iqg A: [137588] automated match to d1fkna_ complexed with f2i |
Domain d2irza_: 2irz A: [165653] automated match to d1fkna_ complexed with i02 |
Domain d2is0a_: 2is0 A: [165654] automated match to d1fkna_ complexed with i03 |
Domain d2ntra_: 2ntr A: [166358] automated match to d1fkna_ complexed with l00 |
Domain d2oaha_: 2oah A: [166603] automated match to d1fkna_ complexed with qin |
Domain d2of0a_: 2of0 A: [139041] automated match to d1fkna_ complexed with cmz, dms, iod |
Domain d2ohka_: 2ohk A: [139070] automated match to d1fkna_ complexed with 1sq, dms, iod |
Domain d2ohla_: 2ohl A: [139071] automated match to d1fkna_ complexed with 2aq, dms, iod |
Domain d2ohma_: 2ohm A: [139072] automated match to d1fkna_ complexed with 8ap, dms, iod |
Domain d2ohna_: 2ohn A: [139073] automated match to d1fkna_ complexed with 4fp, dms, iod |
Domain d2ohpa_: 2ohp A: [139074] automated match to d1fkna_ complexed with 6ip, dms, iod |
Domain d2ohqa_: 2ohq A: [139075] automated match to d1fkna_ complexed with 7ip, dms, gol, iod |
Domain d2ohra_: 2ohr A: [139076] automated match to d1fkna_ complexed with 8ip, dms, gol, iod |
Domain d2ohsa_: 2ohs A: [139077] automated match to d1fkna_ complexed with 9ip, dms, iod |
Domain d2ohta_: 2oht A: [139078] automated match to d1fkna_ complexed with dms, iod, ip6 |
Domain d2ohua_: 2ohu A: [139079] automated match to d1fkna_ complexed with dms, iod, ip7 |
Domain d2p4ja_: 2p4j A: [149210] automated match to d1fkna_ complexed with 23i |
Domain d2p4jb_: 2p4j B: [149211] automated match to d1fkna_ complexed with 23i |
Domain d2p4jc_: 2p4j C: [149212] automated match to d1fkna_ complexed with 23i |
Domain d2p4jd_: 2p4j D: [149213] automated match to d1fkna_ complexed with 23i |
Domain d2p83a1: 2p83 A:61P-385 [139519] automatically matched to d1fkna_ complexed with mr0, po4 |
Domain d2p83b1: 2p83 B:61P-385 [139520] automatically matched to d1fkna_ complexed with mr0, po4 |
Domain d2p83c1: 2p83 C:61P-385 [139521] automatically matched to d1fkna_ complexed with mr0, po4 |
Domain d2p8ha_: 2p8h A: [167081] automated match to d1fkna_ complexed with my9 |
Domain d2ph6a_: 2ph6 A: [167189] automated match to d1fkna_ complexed with 712, so4 |
Domain d2ph8a_: 2ph8 A: [167190] automated match to d1fkna_ complexed with 35a, so4 |
Domain d2q11a_: 2q11 A: [167385] automated match to d1fkna_ complexed with xx4 |
Domain d2q11b_: 2q11 B: [167386] automated match to d1fkna_ complexed with xx4 |
Domain d2q11c_: 2q11 C: [167387] automated match to d1fkna_ complexed with xx4 |
Domain d2q15a_: 2q15 A: [167388] automated match to d1fkna_ complexed with 3mr |
Domain d2qk5a_: 2qk5 A: [150837] automated match to d1fkna_ complexed with cs5 |
Domain d2qk5b_: 2qk5 B: [150838] automated match to d1fkna_ complexed with cs5 |
Domain d2qmda_: 2qmd A: [150878] automated match to d1fkna_ complexed with cs7, tar |
Domain d2qmdb_: 2qmd B: [150879] automated match to d1fkna_ complexed with cs7, tar |
Domain d2qmfa_: 2qmf A: [150880] automated match to d1fkna_ complexed with cs9, tar |
Domain d2qmfb_: 2qmf B: [150881] automated match to d1fkna_ complexed with cs9, tar |
Domain d2qmga_: 2qmg A: [150882] automated match to d1fkna_ complexed with sc6, tar |
Domain d2qmgb_: 2qmg B: [150883] automated match to d1fkna_ complexed with sc6, tar |
Domain d2qp8a_: 2qp8 A: [151197] automated match to d1fkna_ complexed with sc7, tar |
Domain d2qp8b_: 2qp8 B: [151198] automated match to d1fkna_ complexed with sc7, tar |
Domain d2qu2a_: 2qu2 A: [151363] automated match to d1fkna_ complexed with 251 |
Domain d2qu3a_: 2qu3 A: [151364] automated match to d1fkna_ complexed with 462 |
Domain d2qzka_: 2qzk A: [167891] automated match to d1fkna_ complexed with i21 |
Domain d2va5a1: 2va5 A:-1-385 [152821] automatically matched to d1fkna_ complexed with c8c, iod |
Domain d2va6a1: 2va6 A:-1-385 [152822] automatically matched to d1fkna_ complexed with h24, iod |
Domain d2va7a1: 2va7 A:-1-385 [152823] automatically matched to d1fkna_ complexed with c27, iod |
Domain d2vkma_: 2vkm A: [168665] automated match to d1fkna_ complexed with bsd |
Domain d2vkmb_: 2vkm B: [168666] automated match to d1fkna_ complexed with bsd |
Domain d2vkmc_: 2vkm C: [168667] automated match to d1fkna_ complexed with bsd |
Domain d2vkmd_: 2vkm D: [168668] automated match to d1fkna_ complexed with bsd |
Domain d2zdza_: 2zdz A: [171163] automated match to d1fkna_ complexed with 310 |
Domain d2ze1a_: 2ze1 A: [171164] automated match to d1fkna_ complexed with 411 |
Domain d2zhra_: 2zhr A: [154468] automated match to d1fkna_ |
Domain d2zhrb_: 2zhr B: [154469] automated match to d1fkna_ |
Domain d2zhsa_: 2zhs A: [154470] automated match to d1fkna_ |
Domain d2zhta_: 2zht A: [154471] automated match to d1fkna_ |
Domain d2zhua_: 2zhu A: [154472] automated match to d1fkna_ |
Domain d2zhva_: 2zhv A: [154473] automated match to d1fkna_ |
Domain d2zjha_: 2zjh A: [171246] automated match to d1fkna_ complexed with f1h |
Domain d2zjia_: 2zji A: [171247] automated match to d1fkna_ complexed with f1i |
Domain d2zjja_: 2zjj A: [171248] automated match to d1fkna_ complexed with f1j |
Domain d2zjla_: 2zjl A: [171249] automated match to d1fkna_ complexed with f1l |
Domain d2zjma_: 2zjm A: [171250] automated match to d1fkna_ complexed with f1m |
Domain d2zjna_: 2zjn A: [171251] automated match to d1fkna_ complexed with f1n |
Domain d3ciba_: 3cib A: [156664] automated match to d1fkna_ complexed with 314, tar |
Domain d3cibb_: 3cib B: [156665] automated match to d1fkna_ complexed with 314, tar |
Domain d3cica_: 3cic A: [156666] automated match to d1fkna_ complexed with 316, tar |
Domain d3cicb_: 3cic B: [156667] automated match to d1fkna_ complexed with 316, tar |
Domain d3cida_: 3cid A: [156668] automated match to d1fkna_ complexed with 318, tar |
Domain d3cidb_: 3cid B: [156669] automated match to d1fkna_ complexed with 318, tar |
Domain d3duya_: 3duy A: [174252] automated match to d1fkna_ complexed with afj |
Domain d3duyb_: 3duy B: [174253] automated match to d1fkna_ complexed with afj |
Domain d3duyc_: 3duy C: [174254] automated match to d1fkna_ complexed with afj |
Domain d3dv1a_: 3dv1 A: [174259] automated match to d1fkna_ complexed with ar9 |
Domain d3dv1b_: 3dv1 B: [174260] automated match to d1fkna_ complexed with ar9 |
Domain d3dv1c_: 3dv1 C: [174261] automated match to d1fkna_ complexed with ar9 |
Domain d3dv5a_: 3dv5 A: [174267] automated match to d1fkna_ complexed with bav |
Domain d3dv5b_: 3dv5 B: [174268] automated match to d1fkna_ complexed with bav |
Domain d3dv5c_: 3dv5 C: [174269] automated match to d1fkna_ complexed with bav |
Domain d3exoa_: 3exo A: [175292] automated match to d1fkna_ complexed with 5ms, gol, so4 |
Domain d3fkta_: 3fkt A: [175858] automated match to d1fkna_ complexed with sii |
Domain d3hvga_: 3hvg A: [177866] automated match to d1fkna_ complexed with ev0, gol |
Domain d3hvgb_: 3hvg B: [177867] automated match to d1fkna_ complexed with ev0, gol |
Domain d3hvgc_: 3hvg C: [177868] automated match to d1fkna_ complexed with ev0, gol |
Domain d3hw1a_: 3hw1 A: [177884] automated match to d1fkna_ complexed with ev2, gol |
Domain d3hw1b_: 3hw1 B: [177885] automated match to d1fkna_ complexed with ev2, gol |
Domain d3hw1c_: 3hw1 C: [177886] automated match to d1fkna_ complexed with ev2, gol |
Domain d3i25a_: 3i25 A: [178023] automated match to d1fkna_ complexed with mv7 |
Domain d3i25b_: 3i25 B: [178024] automated match to d1fkna_ complexed with mv7 |
Domain d3i25c_: 3i25 C: [178025] automated match to d1fkna_ complexed with mv7 |
Domain d3igba_: 3igb A: [178305] automated match to d1fkna_ complexed with 454 |
Domain d3in3a_: 3in3 A: [178435] automated match to d1fkna_ complexed with 472 |
Domain d3in4a_: 3in4 A: [178436] automated match to d1fkna_ complexed with bx2 |
Domain d3inda_: 3ind A: [178440] automated match to d1fkna_ complexed with 593 |
Domain d3inea_: 3ine A: [178441] automated match to d1fkna_ complexed with x17 |
Domain d3infa_: 3inf A: [178442] automated match to d1fkna_ complexed with x45 |
Domain d3inha_: 3inh A: [178443] automated match to d1fkna_ complexed with 569 |
Domain d3ivha_: 3ivh A: [178629] automated match to d1fkna_ complexed with 1li |
Domain d3ivia_: 3ivi A: [178630] automated match to d1fkna_ complexed with 2li, gol, so4 |
Domain d3ivib_: 3ivi B: [178631] automated match to d1fkna_ complexed with 2li, gol, so4 |
Domain d3ivic_: 3ivi C: [178632] automated match to d1fkna_ complexed with 2li, gol, so4 |
Domain d3ixja_: 3ixj A: [178673] automated match to d1fkna_ protein/RNA complex; complexed with 586, so4 |
Domain d3ixjb_: 3ixj B: [178674] automated match to d1fkna_ protein/RNA complex; complexed with 586, so4 |
Domain d3ixjc_: 3ixj C: [178675] automated match to d1fkna_ protein/RNA complex; complexed with 586, so4 |
Domain d3ixka_: 3ixk A: [178676] automated match to d1fkna_ complexed with 929 |
Domain d3ixkb_: 3ixk B: [178677] automated match to d1fkna_ complexed with 929 |
Domain d3ixkc_: 3ixk C: [178678] automated match to d1fkna_ complexed with 929 |
Domain d3k5ca_: 3k5c A: [179090] automated match to d1fkna_ complexed with 0bi |
Domain d3k5cb_: 3k5c B: [179091] automated match to d1fkna_ complexed with 0bi |
Domain d3k5cc_: 3k5c C: [179092] automated match to d1fkna_ complexed with 0bi |
Domain d3k5da_: 3k5d A: [179093] automated match to d1fkna_ complexed with xli |
Domain d3k5db_: 3k5d B: [179094] automated match to d1fkna_ complexed with xli |
Domain d3k5dc_: 3k5d C: [179095] automated match to d1fkna_ complexed with xli |
Domain d3k5fa_: 3k5f A: [179098] automated match to d1fkna_ complexed with ayh |
Domain d3k5fb_: 3k5f B: [179099] automated match to d1fkna_ complexed with ayh |
Domain d3k5fc_: 3k5f C: [179100] automated match to d1fkna_ complexed with ayh |
Domain d3k5ga_: 3k5g A: [179101] automated match to d1fkna_ complexed with bjc |
Domain d3k5gb_: 3k5g B: [179102] automated match to d1fkna_ complexed with bjc |
Domain d3k5gc_: 3k5g C: [179103] automated match to d1fkna_ complexed with bjc |
Domain d3kmxa_: 3kmx A: [179461] automated match to d1fkna_ complexed with g00 |
Domain d3kmxb_: 3kmx B: [179462] automated match to d1fkna_ complexed with g00 |
Domain d3kmya_: 3kmy A: [179463] automated match to d1fkna_ complexed with d8y |
Domain d3kmyb_: 3kmy B: [179464] automated match to d1fkna_ complexed with d8y |
Domain d3kn0a_: 3kn0 A: [179465] automated match to d1fkna_ complexed with 3to, tla |
Domain d3kn0b_: 3kn0 B: [179466] automated match to d1fkna_ complexed with 3to, tla |
Domain d3kyra_: 3kyr A: [179811] automated match to d1fkna_ complexed with 038 |
Domain d3kyrb_: 3kyr B: [179812] automated match to d1fkna_ complexed with 038 |
Domain d3kyrc_: 3kyr C: [179813] automated match to d1fkna_ complexed with 038 |
Domain d3l38a_: 3l38 A: [179900] automated match to d1fkna_ complexed with 879 |
Domain d3l3aa_: 3l3a A: [179901] automated match to d1fkna_ complexed with 625 |
Domain d3l58a_: 3l58 A: [179951] automated match to d1fkna_ complexed with cs5 |
Domain d3l58b_: 3l58 B: [179952] automated match to d1fkna_ complexed with cs5 |
Domain d3l59a_: 3l59 A: [179953] automated match to d1fkna_ complexed with bdj, tar |
Domain d3l59b_: 3l59 B: [179954] automated match to d1fkna_ complexed with bdj, tar |
Domain d3l5ba_: 3l5b A: [179955] automated match to d1fkna_ complexed with bdo, tar |
Domain d3l5bb_: 3l5b B: [179956] automated match to d1fkna_ complexed with bdo, tar |
Domain d3l5ca_: 3l5c A: [179957] automated match to d1fkna_ complexed with bdq, tar |
Domain d3l5cb_: 3l5c B: [179958] automated match to d1fkna_ complexed with bdq, tar |
Domain d3l5da_: 3l5d A: [179959] automated match to d1fkna_ complexed with bdv, tar |
Domain d3l5db_: 3l5d B: [179960] automated match to d1fkna_ complexed with bdv, tar |
Domain d3l5ea_: 3l5e A: [179961] automated match to d1fkna_ complexed with bdw, tar |
Domain d3l5eb_: 3l5e B: [179962] automated match to d1fkna_ complexed with bdw, tar |
Domain d3l5fa_: 3l5f A: [179963] automated match to d1fkna_ complexed with bdx, tar |
Domain d3l5fb_: 3l5f B: [179964] automated match to d1fkna_ complexed with bdx, tar |
Domain d3lhga_: 3lhg A: [180287] automated match to d1fkna_ complexed with z81 |
Domain d3lnka_: 3lnk A: [180411] automated match to d1fkna_ complexed with 74a, tla |
Domain d3lnkb_: 3lnk B: [180412] automated match to d1fkna_ complexed with 74a, tla |
Domain d3msja_: 3msj A: [181530] automated match to d1fkna_ complexed with ev3, gol |
Domain d3msjb_: 3msj B: [181531] automated match to d1fkna_ complexed with ev3, gol |
Domain d3msjc_: 3msj C: [181532] automated match to d1fkna_ complexed with ev3, gol |
Domain d3mska_: 3msk A: [181533] automated match to d1fkna_ complexed with ev4, gol, iod |
Domain d3msla_: 3msl A: [181534] automated match to d1fkna_ complexed with ev5, iod |
Domain d3n4la_: 3n4l A: [181896] automated match to d1fkna_ complexed with 842 |
Domain d3n4lb_: 3n4l B: [181897] automated match to d1fkna_ complexed with 842 |
Domain d3n4lc_: 3n4l C: [181898] automated match to d1fkna_ complexed with 842 |
Domain d3nsha_: 3nsh A: [182507] automated match to d1fkna_ complexed with 957 |
Domain d3nshb_: 3nsh B: [182508] automated match to d1fkna_ complexed with 957 |
Domain d3nshc_: 3nsh C: [182509] automated match to d1fkna_ complexed with 957 |
Domain d3pi5a_: 3pi5 A: [183756] automated match to d1fkna_ complexed with 3p5 |
Domain d3pi5b_: 3pi5 B: [183757] automated match to d1fkna_ complexed with 3p5 |
Domain d3pi5c_: 3pi5 C: [183758] automated match to d1fkna_ complexed with 3p5 |
Domain d3qbha_: 3qbh A: [184319] automated match to d1fkna_ complexed with qbh |
Domain d3qbhb_: 3qbh B: [184320] automated match to d1fkna_ complexed with qbh |
Domain d3qbhc_: 3qbh C: [184321] automated match to d1fkna_ complexed with qbh |
Domain d3r1gb_: 3r1g B: [184774] automated match to d1fkna_ |
Domain d3s2oa_: 3s2o A: [185255] automated match to d1fkna_ complexed with ev6, iod |
Domain d3u6aa_: 3u6a A: [186093] automated match to d1fkna_ complexed with 18p, so4 |
Domain d3u6ab_: 3u6a B: [186094] automated match to d1fkna_ complexed with 18p, so4 |
Domain d3u6ac_: 3u6a C: [186095] automated match to d1fkna_ complexed with 18p, so4 |
Domain d3ufla_: 3ufl A: [186255] automated match to d1fkna_ complexed with 508, gol, so4 |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from b.50.1.2 beta-secretase (memapsin):