PDB entry 1xn2
View 1xn2 on RCSB PDB site
Description: New substrate binding pockets for beta-secretase.
Class: hydrolase/hydrolase inhibitor
Keywords: beta secretase, memapsin2, BACE, ASP2, Aspartic protease, Alzheimer's disease, Drug design, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2004-10-04, released
2005-03-22
The last revision prior to the SCOPe 2.01 freeze date was dated
2011-07-13, with a file datestamp of
2011-07-07.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.193
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Beta-secretase 1
Species: Homo sapiens [TaxId:9606]
Gene: BACE1, BACE
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1xn2a_ - Chain 'B':
Compound: Beta-secretase 1
Species: Homo sapiens [TaxId:9606]
Gene: BACE1, BACE
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1xn2b_ - Chain 'C':
Compound: Beta-secretase 1
Species: Homo sapiens [TaxId:9606]
Gene: BACE1, BACE
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1xn2c_ - Chain 'D':
Compound: Beta-secretase 1
Species: Homo sapiens [TaxId:9606]
Gene: BACE1, BACE
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1xn2d_ - Chain 'E':
Compound: om03-4
Database cross-references and differences (RAF-indexed):
- Chain 'F':
Compound: om03-4
Database cross-references and differences (RAF-indexed):
- Chain 'G':
Compound: om03-4
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: om03-4
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1xn2A (A:)
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1xn2B (B:)
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>1xn2C (C:)
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>1xn2D (D:)
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn
- Chain 'E':
No sequence available.
- Chain 'F':
No sequence available.
- Chain 'G':
No sequence available.
- Chain 'H':
No sequence available.