Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOP 1.75
  2. 781541Class b: All beta proteins [48724] (174 folds)
  3. 803906Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 803907Superfamily b.50.1: Acid proteases [50630] (3 families) (S)
  5. 804499Family b.50.1.2: Pepsin-like [50646] (10 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 804554Protein beta-secretase (memapsin) [50671] (1 species)
  7. 804555Species Human (Homo sapiens) [TaxId:9606] [50672] (51 PDB entries)
    Uniprot P56817 58-446
    Uniprot P56817 60-447
    Uniprot P56817 58-446 ! Uniprot P56817 60-447

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1fkn:
    1. 804578Domain d1fkna_: 1fkn A: [26879]
    2. 804579Domain d1fknb_: 1fkn B: [26880]
      complexed with alq, lol
  2. Domain(s) for 1m4h:
    1. 804604Domain d1m4ha_: 1m4h A: [74455]
    2. 804605Domain d1m4hb_: 1m4h B: [74456]
      complexed with alq, lol
  3. Domain(s) for 1sgz:
    1. 804584Domain d1sgza_: 1sgz A: [98872]
    2. 804585Domain d1sgzb_: 1sgz B: [98873]
    3. 804586Domain d1sgzc_: 1sgz C: [98874]
    4. 804587Domain d1sgzd_: 1sgz D: [98875]
  4. Domain(s) for 1tqf:
  5. Domain(s) for 1w50:
  6. Domain(s) for 1w51:
  7. Domain(s) for 1xn2:
    1. 804580Domain d1xn2a1: 1xn2 A:45P-385 [122178]
      automatically matched to d1fkna_
      complexed with alq
    2. 804581Domain d1xn2b1: 1xn2 B:45P-385 [122179]
      automatically matched to d1fkna_
      complexed with alq
    3. 804582Domain d1xn2c1: 1xn2 C:45P-385 [122180]
      automatically matched to d1fkna_
      complexed with alq
    4. 804583Domain d1xn2d1: 1xn2 D:45P-385 [122181]
      automatically matched to d1fkna_
      complexed with alq
  8. Domain(s) for 1xn3:
    1. 804589Domain d1xn3a1: 1xn3 A:45P-385 [122182]
      automatically matched to d1fkna_
      complexed with sta
    2. 804590Domain d1xn3b1: 1xn3 B:45P-385 [122183]
      automatically matched to d1fkna_
      complexed with sta
    3. 804591Domain d1xn3c1: 1xn3 C:45P-385 [122184]
      automatically matched to d1fkna_
      complexed with sta
    4. 804592Domain d1xn3d1: 1xn3 D:45P-385 [122185]
      automatically matched to d1fkna_
      complexed with sta
  9. Domain(s) for 1xs7:
  10. Domain(s) for 1ym2:
    1. 804593Domain d1ym2a1: 1ym2 A:-2-385 [123679]
      automatically matched to d1fkna_
      complexed with aua
    2. 804594Domain d1ym2b1: 1ym2 B:-2-385 [123680]
      automatically matched to d1fkna_
      complexed with aua
    3. 804595Domain d1ym2c1: 1ym2 C:-2-385 [123681]
      automatically matched to d1fkna_
      complexed with aua
  11. Domain(s) for 1ym4:
    1. 804632Domain d1ym4a1: 1ym4 A:-3-385 [123682]
      automatically matched to d1fkna_
      complexed with amk
    2. 804633Domain d1ym4b1: 1ym4 B:-2-385 [123683]
      automatically matched to d1fkna_
      complexed with amk
    3. 804634Domain d1ym4c1: 1ym4 C:-3-385 [123684]
      automatically matched to d1fkna_
      complexed with amk
  12. Domain(s) for 2f3e:
    1. 804596Domain d2f3ea1: 2f3e A:46P-385 [132864]
      automatically matched to d1fkna_
      complexed with axq
    2. 804597Domain d2f3eb1: 2f3e B:46P-385 [132865]
      automatically matched to d1fkna_
      complexed with axq
    3. 804598Domain d2f3ec1: 2f3e C:46P-385 [132866]
      automatically matched to d1fkna_
      complexed with axq
  13. Domain(s) for 2f3f:
    1. 804600Domain d2f3fa1: 2f3f A:46P-385 [132867]
      automatically matched to d1fkna_
      complexed with axf
    2. 804601Domain d2f3fb1: 2f3f B:46P-385 [132868]
      automatically matched to d1fkna_
      complexed with axf
    3. 804602Domain d2f3fc1: 2f3f C:46P-385 [132869]
      automatically matched to d1fkna_
      complexed with axf
  14. Domain(s) for 2fdp:
    1. 804640Domain d2fdpa1: 2fdp A:46P-385 [133316]
      automatically matched to d1fkna_
      complexed with frp
    2. 804641Domain d2fdpb1: 2fdp B:46P-385 [133317]
      automatically matched to d1fkna_
      complexed with frp
    3. 804642Domain d2fdpc1: 2fdp C:46P-385 [133318]
      automatically matched to d1fkna_
      complexed with frp
  15. Domain(s) for 2g94:
    1. 804572Domain d2g94a1: 2g94 A:45P-385 [134790]
      automatically matched to d1fkna_
      complexed with zpq
    2. 804573Domain d2g94b1: 2g94 B:45P-385 [134791]
      automatically matched to d1fkna_
      complexed with zpq
    3. 804574Domain d2g94c1: 2g94 C:45P-385 [134792]
      automatically matched to d1fkna_
      complexed with zpq
    4. 804575Domain d2g94d1: 2g94 D:45P-385 [134793]
      automatically matched to d1fkna_
      complexed with zpq
  16. Domain(s) for 2hiz:
    1. 804624Domain d2hiza1: 2hiz A:61P-385 [136533]
      automatically matched to d1fkna_
      complexed with lij, po4
    2. 804625Domain d2hizb1: 2hiz B:61P-385 [136534]
      automatically matched to d1fkna_
      complexed with lij, po4
    3. 804626Domain d2hizc1: 2hiz C:61P-385 [136535]
      automatically matched to d1fkna_
      complexed with lij, po4
  17. Domain(s) for 2hm1:
  18. Domain(s) for 2iqg:
  19. Domain(s) for 2of0:
  20. Domain(s) for 2ohk:
  21. Domain(s) for 2ohl:
  22. Domain(s) for 2ohm:
  23. Domain(s) for 2ohn:
  24. Domain(s) for 2ohp:
  25. Domain(s) for 2ohq:
  26. Domain(s) for 2ohr:
  27. Domain(s) for 2ohs:
  28. Domain(s) for 2oht:
  29. Domain(s) for 2ohu:
  30. Domain(s) for 2p4j:
    1. 804627Domain d2p4ja1: 2p4j A:47P-385 [149210]
      automatically matched to d1fkna_
      complexed with 23i
    2. 804628Domain d2p4jb1: 2p4j B:47P-385 [149211]
      automatically matched to d1fkna_
      complexed with 23i
    3. 804629Domain d2p4jc1: 2p4j C:47P-385 [149212]
      automatically matched to d1fkna_
      complexed with 23i
    4. 804630Domain d2p4jd1: 2p4j D:47P-385 [149213]
      automatically matched to d1fkna_
      complexed with 23i
  31. Domain(s) for 2p83:
    1. 804621Domain d2p83a1: 2p83 A:61P-385 [139519]
      automatically matched to d1fkna_
      complexed with mr0, po4
    2. 804622Domain d2p83b1: 2p83 B:61P-385 [139520]
      automatically matched to d1fkna_
      complexed with mr0, po4
    3. 804623Domain d2p83c1: 2p83 C:61P-385 [139521]
      automatically matched to d1fkna_
      complexed with mr0, po4
  32. Domain(s) for 2qk5:
    1. 804576Domain d2qk5a1: 2qk5 A:60-446 [150837]
      automatically matched to d1fkna_
      complexed with cs5
    2. 804577Domain d2qk5b1: 2qk5 B:60-446 [150838]
      automatically matched to d1fkna_
      complexed with cs5
  33. Domain(s) for 2qmd:
    1. 804558Domain d2qmda1: 2qmd A:60-446 [150878]
      automatically matched to d1fkna_
      complexed with cs7, tar
    2. 804559Domain d2qmdb1: 2qmd B:60-446 [150879]
      automatically matched to d1fkna_
      complexed with cs7, tar
  34. Domain(s) for 2qmf:
    1. 804567Domain d2qmfa1: 2qmf A:60-446 [150880]
      automatically matched to d1fkna_
      complexed with cs9, tar
    2. 804568Domain d2qmfb1: 2qmf B:60-446 [150881]
      automatically matched to d1fkna_
      complexed with cs9, tar
  35. Domain(s) for 2qmg:
    1. 804569Domain d2qmga1: 2qmg A:60-446 [150882]
      automatically matched to d1fkna_
      complexed with sc6, tar
    2. 804570Domain d2qmgb1: 2qmg B:60-446 [150883]
      automatically matched to d1fkna_
      complexed with sc6, tar
  36. Domain(s) for 2qp8:
    1. 804556Domain d2qp8a1: 2qp8 A:60-446 [151197]
      automatically matched to d1fkna_
      complexed with sc7, tar
    2. 804557Domain d2qp8b1: 2qp8 B:60-446 [151198]
      automatically matched to d1fkna_
      complexed with sc7, tar
  37. Domain(s) for 2qu2:
  38. Domain(s) for 2qu3:
  39. Domain(s) for 2va5:
  40. Domain(s) for 2va6:
  41. Domain(s) for 2va7:
  42. Domain(s) for 2zhr:
    1. 804608Domain d2zhra1: 2zhr A:-1-385 [154468]
      automatically matched to d1fkna_
      complexed with alq, lol
    2. 804609Domain d2zhrb1: 2zhr B:-1-385 [154469]
      automatically matched to d1fkna_
      complexed with alq, lol
  43. Domain(s) for 2zhs:
  44. Domain(s) for 2zht:
  45. Domain(s) for 2zhu:
  46. Domain(s) for 2zhv:
  47. Domain(s) for 3cib:
    1. 804560Domain d3ciba1: 3cib A:60-446 [156664]
      automatically matched to d1fkna_
      complexed with 314, tar
    2. 804561Domain d3cibb1: 3cib B:60-446 [156665]
      automatically matched to d1fkna_
      complexed with 314, tar
  48. Domain(s) for 3cic:
    1. 804562Domain d3cica1: 3cic A:60-446 [156666]
      automatically matched to d1fkna_
      complexed with 316, tar
    2. 804563Domain d3cicb1: 3cic B:60-446 [156667]
      automatically matched to d1fkna_
      complexed with 316, tar
  49. Domain(s) for 3cid:
    1. 804564Domain d3cida1: 3cid A:60-446 [156668]
      automatically matched to d1fkna_
      complexed with 318, tar
    2. 804565Domain d3cidb1: 3cid B:60-446 [156669]
      automatically matched to d1fkna_
      complexed with 318, tar
  50. Domain(s) for 3ckp:
    1. 804635Domain d3ckpa1: 3ckp A:-2-385 [156740]
      automatically matched to d1fkna_
      complexed with 012, cl; mutant
    2. 804636Domain d3ckpb1: 3ckp B:-2-385 [156741]
      automatically matched to d1fkna_
      complexed with 012, cl; mutant
    3. 804637Domain d3ckpc1: 3ckp C:-2-385 [156742]
      automatically matched to d1fkna_
      complexed with 012, cl; mutant
  51. Domain(s) for 3ckr:
    1. 804648Domain d3ckra1: 3ckr A:-2-385 [156743]
      automatically matched to d1fkna_
      complexed with 009; mutant
    2. 804649Domain d3ckrb1: 3ckr B:-2-385 [156744]
      automatically matched to d1fkna_
      complexed with 009; mutant
    3. 804650Domain d3ckrc1: 3ckr C:-2-385 [156745]
      automatically matched to d1fkna_
      complexed with 009; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from b.50.1.2 beta-secretase (memapsin)

Timeline for Species Human (Homo sapiens) [TaxId:9606] from b.50.1.2 beta-secretase (memapsin):