![]() | Class b: All beta proteins [48724] (174 folds) |
![]() | Fold b.50: Acid proteases [50629] (1 superfamily) barrel, closed; n=6, S=10, complex topology |
![]() | Superfamily b.50.1: Acid proteases [50630] (3 families) ![]() |
![]() | Family b.50.1.2: Pepsin-like [50646] (10 proteins) duplication: consists of two similar barrel domains N-terminal: barrel, partly opened; n*=6, S*=10 |
![]() | Protein beta-secretase (memapsin) [50671] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [50672] (51 PDB entries) Uniprot P56817 58-446 Uniprot P56817 60-447 Uniprot P56817 58-446 ! Uniprot P56817 60-447 |
![]() | Domain d1fkna_: 1fkn A: [26879] |
![]() | Domain d1fknb_: 1fkn B: [26880] complexed with alq, lol |
![]() | Domain d1m4ha_: 1m4h A: [74455] |
![]() | Domain d1m4hb_: 1m4h B: [74456] complexed with alq, lol |
![]() | Domain d1sgza_: 1sgz A: [98872] |
![]() | Domain d1sgzb_: 1sgz B: [98873] |
![]() | Domain d1sgzc_: 1sgz C: [98874] |
![]() | Domain d1sgzd_: 1sgz D: [98875] |
![]() | Domain d1tqfa_: 1tqf A: [112613] complexed with 32p; mutant |
![]() | Domain d1w50a_: 1w50 A: [109173] complexed with iod; mutant |
![]() | Domain d1w51a_: 1w51 A: [109174] complexed with iod, l01; mutant |
![]() | Domain d1xn2a1: 1xn2 A:45P-385 [122178] automatically matched to d1fkna_ complexed with alq |
![]() | Domain d1xn2b1: 1xn2 B:45P-385 [122179] automatically matched to d1fkna_ complexed with alq |
![]() | Domain d1xn2c1: 1xn2 C:45P-385 [122180] automatically matched to d1fkna_ complexed with alq |
![]() | Domain d1xn2d1: 1xn2 D:45P-385 [122181] automatically matched to d1fkna_ complexed with alq |
![]() | Domain d1xn3a1: 1xn3 A:45P-385 [122182] automatically matched to d1fkna_ complexed with sta |
![]() | Domain d1xn3b1: 1xn3 B:45P-385 [122183] automatically matched to d1fkna_ complexed with sta |
![]() | Domain d1xn3c1: 1xn3 C:45P-385 [122184] automatically matched to d1fkna_ complexed with sta |
![]() | Domain d1xn3d1: 1xn3 D:45P-385 [122185] automatically matched to d1fkna_ complexed with sta |
![]() | Domain d1xs7d_: 1xs7 D: [115919] complexed with mmi |
![]() | Domain d1ym2a1: 1ym2 A:-2-385 [123679] automatically matched to d1fkna_ complexed with aua |
![]() | Domain d1ym2b1: 1ym2 B:-2-385 [123680] automatically matched to d1fkna_ complexed with aua |
![]() | Domain d1ym2c1: 1ym2 C:-2-385 [123681] automatically matched to d1fkna_ complexed with aua |
![]() | Domain d1ym4a1: 1ym4 A:-3-385 [123682] automatically matched to d1fkna_ complexed with amk |
![]() | Domain d1ym4b1: 1ym4 B:-2-385 [123683] automatically matched to d1fkna_ complexed with amk |
![]() | Domain d1ym4c1: 1ym4 C:-3-385 [123684] automatically matched to d1fkna_ complexed with amk |
![]() | Domain d2f3ea1: 2f3e A:46P-385 [132864] automatically matched to d1fkna_ complexed with axq |
![]() | Domain d2f3eb1: 2f3e B:46P-385 [132865] automatically matched to d1fkna_ complexed with axq |
![]() | Domain d2f3ec1: 2f3e C:46P-385 [132866] automatically matched to d1fkna_ complexed with axq |
![]() | Domain d2f3fa1: 2f3f A:46P-385 [132867] automatically matched to d1fkna_ complexed with axf |
![]() | Domain d2f3fb1: 2f3f B:46P-385 [132868] automatically matched to d1fkna_ complexed with axf |
![]() | Domain d2f3fc1: 2f3f C:46P-385 [132869] automatically matched to d1fkna_ complexed with axf |
![]() | Domain d2fdpa1: 2fdp A:46P-385 [133316] automatically matched to d1fkna_ complexed with frp |
![]() | Domain d2fdpb1: 2fdp B:46P-385 [133317] automatically matched to d1fkna_ complexed with frp |
![]() | Domain d2fdpc1: 2fdp C:46P-385 [133318] automatically matched to d1fkna_ complexed with frp |
![]() | Domain d2g94a1: 2g94 A:45P-385 [134790] automatically matched to d1fkna_ complexed with zpq |
![]() | Domain d2g94b1: 2g94 B:45P-385 [134791] automatically matched to d1fkna_ complexed with zpq |
![]() | Domain d2g94c1: 2g94 C:45P-385 [134792] automatically matched to d1fkna_ complexed with zpq |
![]() | Domain d2g94d1: 2g94 D:45P-385 [134793] automatically matched to d1fkna_ complexed with zpq |
![]() | Domain d2hiza1: 2hiz A:61P-385 [136533] automatically matched to d1fkna_ complexed with lij, po4 |
![]() | Domain d2hizb1: 2hiz B:61P-385 [136534] automatically matched to d1fkna_ complexed with lij, po4 |
![]() | Domain d2hizc1: 2hiz C:61P-385 [136535] automatically matched to d1fkna_ complexed with lij, po4 |
![]() | Domain d2hm1a1: 2hm1 A:61P-385 [136571] automatically matched to d1fkna_ complexed with liq |
![]() | Domain d2iqga1: 2iqg A:61P-385 [137588] automatically matched to d1fkna_ complexed with f2i |
![]() | Domain d2of0a1: 2of0 A:-1-385 [139041] automatically matched to d1fkna_ complexed with cmz, dms, iod; mutant |
![]() | Domain d2ohka1: 2ohk A:-1-385 [139070] automatically matched to d1fkna_ complexed with 1sq, dms, iod; mutant |
![]() | Domain d2ohla1: 2ohl A:-1-385 [139071] automatically matched to d1fkna_ complexed with 2aq, dms, iod; mutant |
![]() | Domain d2ohma1: 2ohm A:-1-385 [139072] automatically matched to d1fkna_ complexed with 8ap, dms, iod; mutant |
![]() | Domain d2ohna1: 2ohn A:-1-385 [139073] automatically matched to d1fkna_ complexed with 4fp, dms, iod; mutant |
![]() | Domain d2ohpa1: 2ohp A:-1-385 [139074] automatically matched to d1fkna_ complexed with 6ip, dms, iod; mutant |
![]() | Domain d2ohqa1: 2ohq A:-1-385 [139075] automatically matched to d1fkna_ complexed with 7ip, dms, gol, iod; mutant |
![]() | Domain d2ohra1: 2ohr A:-1-385 [139076] automatically matched to d1fkna_ complexed with 8ip, dms, gol, iod; mutant |
![]() | Domain d2ohsa1: 2ohs A:-1-385 [139077] automatically matched to d1fkna_ complexed with 9ip, dms, iod; mutant |
![]() | Domain d2ohta1: 2oht A:-1-385 [139078] automatically matched to d1fkna_ complexed with dms, iod, ip6; mutant |
![]() | Domain d2ohua1: 2ohu A:-1-385 [139079] automatically matched to d1fkna_ complexed with dms, iod, ip7; mutant |
![]() | Domain d2p4ja1: 2p4j A:47P-385 [149210] automatically matched to d1fkna_ complexed with 23i |
![]() | Domain d2p4jb1: 2p4j B:47P-385 [149211] automatically matched to d1fkna_ complexed with 23i |
![]() | Domain d2p4jc1: 2p4j C:47P-385 [149212] automatically matched to d1fkna_ complexed with 23i |
![]() | Domain d2p4jd1: 2p4j D:47P-385 [149213] automatically matched to d1fkna_ complexed with 23i |
![]() | Domain d2p83a1: 2p83 A:61P-385 [139519] automatically matched to d1fkna_ complexed with mr0, po4 |
![]() | Domain d2p83b1: 2p83 B:61P-385 [139520] automatically matched to d1fkna_ complexed with mr0, po4 |
![]() | Domain d2p83c1: 2p83 C:61P-385 [139521] automatically matched to d1fkna_ complexed with mr0, po4 |
![]() | Domain d2qk5a1: 2qk5 A:60-446 [150837] automatically matched to d1fkna_ complexed with cs5 |
![]() | Domain d2qk5b1: 2qk5 B:60-446 [150838] automatically matched to d1fkna_ complexed with cs5 |
![]() | Domain d2qmda1: 2qmd A:60-446 [150878] automatically matched to d1fkna_ complexed with cs7, tar |
![]() | Domain d2qmdb1: 2qmd B:60-446 [150879] automatically matched to d1fkna_ complexed with cs7, tar |
![]() | Domain d2qmfa1: 2qmf A:60-446 [150880] automatically matched to d1fkna_ complexed with cs9, tar |
![]() | Domain d2qmfb1: 2qmf B:60-446 [150881] automatically matched to d1fkna_ complexed with cs9, tar |
![]() | Domain d2qmga1: 2qmg A:60-446 [150882] automatically matched to d1fkna_ complexed with sc6, tar |
![]() | Domain d2qmgb1: 2qmg B:60-446 [150883] automatically matched to d1fkna_ complexed with sc6, tar |
![]() | Domain d2qp8a1: 2qp8 A:60-446 [151197] automatically matched to d1fkna_ complexed with sc7, tar |
![]() | Domain d2qp8b1: 2qp8 B:60-446 [151198] automatically matched to d1fkna_ complexed with sc7, tar |
![]() | Domain d2qu2a1: 2qu2 A:61-445 [151363] automatically matched to d1fkna_ complexed with 251 |
![]() | Domain d2qu3a1: 2qu3 A:61-445 [151364] automatically matched to d1fkna_ complexed with 462 |
![]() | Domain d2va5a1: 2va5 A:-1-385 [152821] automatically matched to d1fkna_ complexed with c8c, iod; mutant |
![]() | Domain d2va6a1: 2va6 A:-1-385 [152822] automatically matched to d1fkna_ complexed with h24, iod; mutant |
![]() | Domain d2va7a1: 2va7 A:-1-385 [152823] automatically matched to d1fkna_ complexed with c27, iod; mutant |
![]() | Domain d2zhra1: 2zhr A:-1-385 [154468] automatically matched to d1fkna_ complexed with alq, lol |
![]() | Domain d2zhrb1: 2zhr B:-1-385 [154469] automatically matched to d1fkna_ complexed with alq, lol |
![]() | Domain d2zhsa1: 2zhs A:-1-385 [154470] automatically matched to d1fkna_ |
![]() | Domain d2zhta1: 2zht A:-1-385 [154471] automatically matched to d1fkna_ |
![]() | Domain d2zhua1: 2zhu A:-1-385 [154472] automatically matched to d1fkna_ |
![]() | Domain d2zhva1: 2zhv A:-1-385 [154473] automatically matched to d1fkna_ |
![]() | Domain d3ciba1: 3cib A:60-446 [156664] automatically matched to d1fkna_ complexed with 314, tar |
![]() | Domain d3cibb1: 3cib B:60-446 [156665] automatically matched to d1fkna_ complexed with 314, tar |
![]() | Domain d3cica1: 3cic A:60-446 [156666] automatically matched to d1fkna_ complexed with 316, tar |
![]() | Domain d3cicb1: 3cic B:60-446 [156667] automatically matched to d1fkna_ complexed with 316, tar |
![]() | Domain d3cida1: 3cid A:60-446 [156668] automatically matched to d1fkna_ complexed with 318, tar |
![]() | Domain d3cidb1: 3cid B:60-446 [156669] automatically matched to d1fkna_ complexed with 318, tar |
![]() | Domain d3ckpa1: 3ckp A:-2-385 [156740] automatically matched to d1fkna_ complexed with 012, cl; mutant |
![]() | Domain d3ckpb1: 3ckp B:-2-385 [156741] automatically matched to d1fkna_ complexed with 012, cl; mutant |
![]() | Domain d3ckpc1: 3ckp C:-2-385 [156742] automatically matched to d1fkna_ complexed with 012, cl; mutant |
![]() | Domain d3ckra1: 3ckr A:-2-385 [156743] automatically matched to d1fkna_ complexed with 009; mutant |
![]() | Domain d3ckrb1: 3ckr B:-2-385 [156744] automatically matched to d1fkna_ complexed with 009; mutant |
![]() | Domain d3ckrc1: 3ckr C:-2-385 [156745] automatically matched to d1fkna_ complexed with 009; mutant |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from b.50.1.2 beta-secretase (memapsin):