SCOPe 2.08: Protein: 6-pyruvoyl tetrahydropterin synthase

Root: SCOPe 2.08
Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
Fold d.96: T-fold [55619] (2 superfamilies)
beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
tunnel-shaped: its known members form wide oligomeric barrels different sizes
Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families)
bind purine or pterin in topologically similar sites between subunits
Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase [55625] (2 proteins)
Protein 6-pyruvoyl tetrahydropterin synthase [55626] (4 species)
beta-sheets of three subunits form a barrel, closed: n=12, S=12

Malaria parasite (Plasmodium falciparum) [TaxId:5833] [118057] (1 PDB entry)
Uniprot Q6LEZ4
- Domains for 1y13:
  1. Domain d1y13a_: 1y13 A: [116319]
    Structural genomics target
    complexed with bio, zn
  2. Domain d1y13b_: 1y13 B: [116320]
    Structural genomics target
    complexed with bio, zn
  3. Domain d1y13c_: 1y13 C: [116321]
    Structural genomics target
    complexed with bio, zn
Nematode (Caenorhabditis elegans) [TaxId:6239] [143628] (1 PDB entry)
Uniprot O02058 1-139
- Domain for 2g64:
  - Domain d2g64a1: 2g64 A:1-139 [134694]
    complexed with gol, na, zn
Norway rat (Rattus norvegicus) [TaxId:10116] [55627] (3 PDB entries)
1. Domains for 1b66:
  1. Domain d1b66a_: 1b66 A: [40657]
    complexed with bio, zn
  2. Domain d1b66b_: 1b66 B: [40658]
    complexed with bio, zn
2. Domains for 1b6z:
  1. Domain d1b6za_: 1b6z A: [40659]
    complexed with zn
  2. Domain d1b6zb_: 1b6z B: [40660]
    complexed with zn
3. Domains for 1gtq:
  1. Domain d1gtqa_: 1gtq A: [40661]
    complexed with zn
  2. Domain d1gtqb_: 1gtq B: [40662]
    complexed with zn
Plasmodium vivax [TaxId:5855] [143629] (1 PDB entry)
73% similarity to the Plasmodium falciparum enzyme
- Domains for 2a0s:
  1. Domain d2a0sa1: 2a0s A:18-180 [125962]
    complexed with bio, zn
  2. Domain d2a0sb_: 2a0s B: [125963]
    automated match to d2a0sa1
    complexed with bio, zn

Timeline for Protein 6-pyruvoyl tetrahydropterin synthase from d.96.1.2: 6-pyruvoyl tetrahydropterin synthase:

Protein 6-pyruvoyl tetrahydropterin synthase from d.96.1.2: 6-pyruvoyl tetrahydropterin synthase first appeared (with stable ids) in SCOP 1.55
Protein 6-pyruvoyl tetrahydropterin synthase from d.96.1.2: 6-pyruvoyl tetrahydropterin synthase appears in SCOPe 2.07