Lineage for Protein: 6-pyruvoyl tetrahydropterin synthase

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2572796Fold d.96: T-fold [55619] (2 superfamilies)
    beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
    tunnel-shaped: its known members form wide oligomeric barrels different sizes
  4. 2572797Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families) (S)
    bind purine or pterin in topologically similar sites between subunits
  5. 2573026Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase [55625] (2 proteins)
  6. 2573027Protein 6-pyruvoyl tetrahydropterin synthase [55626] (4 species)
    beta-sheets of three subunits form a barrel, closed: n=12, S=12

Species:

  1. 2573028Malaria parasite (Plasmodium falciparum) [TaxId:5833] [118057] (1 PDB entry)
    Uniprot Q6LEZ4
    • Domains for 1y13:
      1. 2573029Domain d1y13a_: 1y13 A: [116319]
        Structural genomics target
        complexed with bio, zn
      2. 2573030Domain d1y13b_: 1y13 B: [116320]
        Structural genomics target
        complexed with bio, zn
      3. 2573031Domain d1y13c_: 1y13 C: [116321]
        Structural genomics target
        complexed with bio, zn
  2. 2573032Nematode (Caenorhabditis elegans) [TaxId:6239] [143628] (1 PDB entry)
    Uniprot O02058 1-139
  3. 2573034Norway rat (Rattus norvegicus) [TaxId:10116] [55627] (3 PDB entries)
    1. Domains for 1b66:
      1. 2573035Domain d1b66a_: 1b66 A: [40657]
        complexed with bio, zn
      2. 2573036Domain d1b66b_: 1b66 B: [40658]
        complexed with bio, zn
    2. Domains for 1b6z:
      1. 2573037Domain d1b6za_: 1b6z A: [40659]
        complexed with zn
      2. 2573038Domain d1b6zb_: 1b6z B: [40660]
        complexed with zn
    3. Domains for 1gtq:
      1. 2573039Domain d1gtqa_: 1gtq A: [40661]
        complexed with zn
      2. 2573040Domain d1gtqb_: 1gtq B: [40662]
        complexed with zn
  4. 2573041Plasmodium vivax [TaxId:5855] [143629] (1 PDB entry)
    73% similarity to the Plasmodium falciparum enzyme

More info for Protein 6-pyruvoyl tetrahydropterin synthase from d.96.1.2: 6-pyruvoyl tetrahydropterin synthase

Timeline for Protein 6-pyruvoyl tetrahydropterin synthase from d.96.1.2: 6-pyruvoyl tetrahydropterin synthase: