SCOPe 2.08: Domain d2a0sa1: 2a0s A:18-180

Lineage for d2a0sa1 (2a0s A:18-180)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.96: T-fold [55619] (2 superfamilies)
   beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
   tunnel-shaped: its known members form wide oligomeric barrels different sizes

4. Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families)
   bind purine or pterin in topologically similar sites between subunits

5. Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase [55625] (2 proteins)

6. Protein 6-pyruvoyl tetrahydropterin synthase [55626] (4 species)
   beta-sheets of three subunits form a barrel, closed: n=12, S=12

7. Species Plasmodium vivax [TaxId:5855] [143629] (1 PDB entry)
   73% similarity to the Plasmodium falciparum enzyme

8. Domain d2a0sa1: 2a0s A:18-180 [125962]
   complexed with bio, zn

Details for d2a0sa1

PDB Entry: 2a0s, 2.2 Å

PDB Description: Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution

PDB Compounds: (A:) 6-pyruvoyl tetrahydropterin synthase

SCOPe Domain Sequences for d2a0sa1:

Sequence; same for both SEQRES and ATOM records:

>d2a0sa1 d.96.1.2 (A:18-180) 6-pyruvoyl tetrahydropterin synthase {Plasmodium vivax [TaxId: 5855]}
dqiaellvesplfsfncahfiafkgfretlhghnynvslrlrgniqgdgyvidfsilkek
vrkvckqldhhfilpmysdvlniqevndnfkitcednseysfpkrdcvqipikhssteei
glyilnqlieeidlpflktrsvnymevtvsespsqkatvhrni

Timeline for d2a0sa1:

• d2a0sa1 first appeared in SCOP 1.73
  
• d2a0sa1 appears in SCOPe 2.07