Lineage for Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2531295Fold d.96: T-fold [55619] (2 superfamilies)
    beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
    tunnel-shaped: its known members form wide oligomeric barrels different sizes
  4. 2531296Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families) (S)
    bind purine or pterin in topologically similar sites between subunits
  5. 2531465Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase [55625] (2 proteins)

Proteins:

  1. 25314666-pyruvoyl tetrahydropterin synthase [55626] (4 species)
    beta-sheets of three subunits form a barrel, closed: n=12, S=12
    1. 2531467Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [118057] (1 PDB entry)
      Uniprot Q6LEZ4
    2. 2531471Species Nematode (Caenorhabditis elegans) [TaxId:6239] [143628] (1 PDB entry)
      Uniprot O02058 1-139
    3. 2531473Species Norway rat (Rattus norvegicus) [TaxId:10116] [55627] (3 PDB entries)
    4. 2531480Species Plasmodium vivax [TaxId:5855] [143629] (1 PDB entry)
      73% similarity to the Plasmodium falciparum enzyme
  2. 2531483automated matches [191141] (1 species)
    not a true protein

More info for Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase

Timeline for Family d.96.1.2: 6-pyruvoyl tetrahydropterin synthase: