| Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
| Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily) consists of two intertwined (sub)domains related by pseudo dyad; duplication 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest |
Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) ![]() the constituent families form similar dimers |
| Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins) the active site is between the two identical subunits |
| Protein automated matches [190072] (18 species) not a true protein |
| Acidithiobacillus thiooxidans [TaxId:930] [187607] (1 PDB entry) |
| Domain d2d4va_: 2d4v A: [163577] automated match to d1isoa_ complexed with flc, nad |
| Domain d2d4vb_: 2d4v B: [163578] automated match to d1isoa_ complexed with flc, nad |
| Domain d2d4vc_: 2d4v C: [163579] automated match to d1isoa_ complexed with flc, nad |
| Domain d2d4vd_: 2d4v D: [163580] automated match to d1isoa_ complexed with flc, nad |
| Archaeoglobus fulgidus [TaxId:2234] [187335] (1 PDB entry) |
| Domain d2iv0a_: 2iv0 A: [165706] automated match to d1ai2a_ complexed with cl, zn |
| Domain d2iv0b_: 2iv0 B: [165707] automated match to d1ai2a_ complexed with cl, zn |
| Bacillus coagulans [TaxId:1398] [186792] (2 PDB entries) |
| Domain d1v53a_: 1v53 A: [119836] automated match to d2ayqb_ |
| Domain d1v53b_: 1v53 B: [119837] automated match to d2ayqb_ |
| Domain d1v5ba_: 1v5b A: [161828] automated match to d2ayqb_ complexed with so4; mutant |
| Domain d1v5bb_: 1v5b B: [161829] automated match to d2ayqb_ complexed with so4; mutant |
| Domain d1v5bc_: 1v5b C: [161830] automated match to d2ayqb_ complexed with so4; mutant |
| Domain d1v5bd_: 1v5b D: [161831] automated match to d2ayqb_ complexed with so4; mutant |
| Domain d1v5be_: 1v5b E: [161832] automated match to d2ayqb_ complexed with so4; mutant |
| Domain d1v5bf_: 1v5b F: [161833] automated match to d2ayqb_ complexed with so4; mutant |
| Domain d1v5bg_: 1v5b G: [161834] automated match to d2ayqb_ complexed with so4; mutant |
| Domain d1v5bh_: 1v5b H: [161835] automated match to d2ayqb_ complexed with so4; mutant |
| Bacillus sp. [TaxId:1409] [233761] (1 PDB entry) |
| Domain d3u1ha_: 3u1h A: [233762] automated match to d3vmja_ |
| Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [225478] (4 PDB entries) |
| Domain d2qfva_: 2qfv A: [205785] automated match to d4hcxb_ complexed with nap |
| Domain d2qfvb_: 2qfv B: [205786] automated match to d4hcxb_ complexed with nap |
| Domain d2qfvc_: 2qfv C: [205787] automated match to d4hcxb_ complexed with nap |
| Domain d2qfvd_: 2qfv D: [205788] automated match to d4hcxb_ complexed with nap |
| Domain d2qfwa_: 2qfw A: [205789] automated match to d4hcxb_ complexed with ict |
| Domain d2qfwb_: 2qfw B: [205790] automated match to d4hcxb_ complexed with ict |
| Domain d2qfwc_: 2qfw C: [205791] automated match to d4hcxb_ complexed with ict |
| Domain d2qfwd_: 2qfw D: [205792] automated match to d4hcxb_ complexed with ict |
| Domain d2qfwe_: 2qfw E: [205793] automated match to d4hcxb_ complexed with ict |
| Domain d2qfwf_: 2qfw F: [205794] automated match to d4hcxb_ complexed with ict |
| Domain d2qfxa_: 2qfx A: [205795] automated match to d4hcxb_ complexed with akg, ca, ndp |
| Domain d2qfxb_: 2qfx B: [205796] automated match to d4hcxb_ complexed with akg, ca, ndp |
| Domain d2qfxc_: 2qfx C: [205797] automated match to d4hcxb_ complexed with akg, ca, ndp |
| Domain d2qfxd_: 2qfx D: [205798] automated match to d4hcxb_ complexed with akg, ca, ndp |
| Domain d2qfxe_: 2qfx E: [205799] automated match to d4hcxb_ complexed with akg, ca, ndp |
| Domain d2qfxf_: 2qfx F: [205800] automated match to d4hcxb_ complexed with akg, ca, ndp |
| Domain d2qfya_: 2qfy A: [205801] automated match to d4hcxb_ complexed with akg |
| Domain d2qfyb_: 2qfy B: [205802] automated match to d4hcxb_ complexed with akg |
| Domain d2qfyc_: 2qfy C: [205803] automated match to d4hcxb_ complexed with akg |
| Domain d2qfyd_: 2qfy D: [205804] automated match to d4hcxb_ complexed with akg |
| Domain d2qfye_: 2qfy E: [205805] automated match to d4hcxb_ complexed with akg |
| Domain d2qfyf_: 2qfy F: [205806] automated match to d4hcxb_ complexed with akg |
| Burkholderia pseudomallei [TaxId:28450] [188497] (1 PDB entry) |
| Domain d3dmsa_: 3dms A: [174063] automated match to d1ai2a_ |
| Burkholderia thailandensis [TaxId:271848] [193254] (1 PDB entry) |
| Domain d4iwha_: 4iwh A: [202678] automated match to d4iwhb_ complexed with mg |
| Domain d4iwhb_: 4iwh B: [193255] automated match to d1a05a_ complexed with mg |
| Campylobacter jejuni [TaxId:197] [189804] (2 PDB entries) |
| Domain d3udoa_: 3udo A: [186238] automated match to d1cm7a_ complexed with edo, so4 |
| Domain d3udua_: 3udu A: [186239] automated match to d1cm7a_ complexed with cl, edo |
| Domain d3udub_: 3udu B: [186240] automated match to d1cm7a_ complexed with cl, edo |
| Domain d3uduc_: 3udu C: [186241] automated match to d1cm7a_ complexed with cl, edo |
| Domain d3udud_: 3udu D: [186242] automated match to d1cm7a_ complexed with cl, edo |
| Domain d3udue_: 3udu E: [186243] automated match to d1cm7a_ complexed with cl, edo |
| Domain d3uduf_: 3udu F: [186244] automated match to d1cm7a_ complexed with cl, edo |
| Domain d3udug_: 3udu G: [186245] automated match to d1cm7a_ complexed with cl, edo |
| Domain d3uduh_: 3udu H: [186246] automated match to d1cm7a_ complexed with cl, edo |
| Escherichia coli K-12 [TaxId:83333] [189313] (1 PDB entry) |
| Domain d3lcbc_: 3lcb C: [180177] automated match to d1p8fa_ complexed with amp, atp, mg |
| Domain d3lcbd_: 3lcb D: [180178] automated match to d1p8fa_ complexed with amp, atp, mg |
| Escherichia coli [TaxId:562] [193425] (5 PDB entries) |
| Domain d4ajaa_: 4aja A: [194429] automated match to d1pb1a_ complexed with ca, ict, so4, tap |
| Domain d4ajba_: 4ajb A: [218932] automated match to d4ajca_ complexed with ict, mg, so4, tap; mutant |
| Domain d4ajca_: 4ajc A: [193426] automated match to d1pb1a_ complexed with a2p, akg, ca, so4; mutant |
| Domain d4ajra_: 4ajr A: [219005] automated match to d4ajca_ complexed with akg, mg, nap, nmn; mutant |
| Domain d4ajsa_: 4ajs A: [219006] automated match to d4ajca_ complexed with a2p, ict, mg, nmn, so4; mutant |
| Escherichia coli [TaxId:833333] [194427] (1 PDB entry) |
| Domain d4aj3a_: 4aj3 A: [194428] automated match to d1pb1a_ complexed with ca, ict, nap |
| Human (Homo sapiens) [TaxId:9606] [189131] (7 PDB entries) |
| Domain d3inma_: 3inm A: [178460] automated match to d1t09a_ protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant |
| Domain d3inmb_: 3inm B: [178461] automated match to d1t09a_ protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant |
| Domain d3inmc_: 3inm C: [178462] automated match to d1t09a_ protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant |
| Domain d3mapa_: 3map A: [180990] automated match to d1t09a_ complexed with ict, nap; mutant |
| Domain d3mapb_: 3map B: [180991] automated match to d1t09a_ complexed with ict, nap; mutant |
| Domain d4ja8a_: 4ja8 A: [202723] automated match to d4ja8b_ complexed with 1k9, ca, gol, ndp; mutant |
| Domain d4ja8b_: 4ja8 B: [197105] automated match to d1lwda_ complexed with 1k9, ca, gol, ndp; mutant |
| Domain d4kzoa_: 4kzo A: [224533] automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
| Domain d4kzob_: 4kzo B: [224534] automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
| Domain d4kzoc_: 4kzo C: [224535] automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
| Domain d4l03a_: 4l03 A: [224536] automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
| Domain d4l03b_: 4l03 B: [224537] automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
| Domain d4l03c_: 4l03 C: [224538] automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
| Domain d4l04b_: 4l04 B: [235250] automated match to d1t0la_ complexed with akg, ca, nap; mutant |
| Domain d4l06a_: 4l06 A: [224539] automated match to d3inmb_ complexed with akg, ca, nap; mutant |
| Domain d4l06b_: 4l06 B: [224540] automated match to d3inmb_ complexed with akg, ca, nap; mutant |
| Domain d4l06c_: 4l06 C: [224541] automated match to d3inmb_ complexed with akg, ca, nap; mutant |
| Domain d4l06d_: 4l06 D: [224542] automated match to d3inmb_ complexed with akg, ca, nap; mutant |
| Domain d4l06e_: 4l06 E: [224543] automated match to d3inmb_ complexed with akg, ca, nap; mutant |
| Domain d4l06f_: 4l06 F: [224544] automated match to d3inmb_ complexed with akg, ca, nap; mutant |
| Mouse (Mus musculus) [TaxId:10090] [187557] (2 PDB entries) |
| Domain d2cmja_: 2cmj A: [163446] automated match to d1t09a_ complexed with nap |
| Domain d2cmjb_: 2cmj B: [163447] automated match to d1t09a_ complexed with nap |
| Domain d2cmva_: 2cmv A: [163454] automated match to d1t09a_ complexed with cd, flc, nap |
| Domain d2cmvb_: 2cmv B: [163455] automated match to d1t09a_ complexed with cd, flc, nap |
| Mycobacterium tuberculosis [TaxId:1773] [193947] (1 PDB entry) |
| Domain d4hcxa_: 4hcx A: [202413] automated match to d4hcxb_ complexed with cl, mn, nap |
| Domain d4hcxb_: 4hcx B: [193948] automated match to d1lwda_ complexed with cl, mn, nap |
| Shewanella oneidensis [TaxId:211586] [194175] (8 PDB entries) |
| Domain d3vkza_: 3vkz A: [217907] automated match to d3vl3a_ complexed with ca, cl, ipm |
| Domain d3vl2a_: 3vl2 A: [217908] automated match to d3vl3a_ complexed with ca, cl, ipm |
| Domain d3vl3a_: 3vl3 A: [195909] automated match to d1cnza_ complexed with ca, cl, ipm |
| Domain d3vl4a_: 3vl4 A: [217909] automated match to d3vl3a_ complexed with ca, cl, ipm |
| Domain d3vl6a_: 3vl6 A: [217910] automated match to d3vl3a_ complexed with ca, cl, ipm |
| Domain d3vl7a_: 3vl7 A: [217911] automated match to d3vl3a_ complexed with ca, cl, ipm |
| Domain d3vmja_: 3vmj A: [197351] automated match to d1cnza_ complexed with cl, ipm, mg |
| Domain d3vmla_: 3vml A: [194176] automated match to d1cnza_ complexed with cl, ipm, mg |
| Sinorhizobium meliloti [TaxId:266834] [226269] (1 PDB entry) |
| Domain d3us8a_: 3us8 A: [217506] automated match to d4ja8b_ complexed with so4 |
| Domain d3us8b_: 3us8 B: [217507] automated match to d4ja8b_ complexed with so4 |
| Thermus thermophilus [TaxId:274] [189081] (5 PDB entries) |
| Domain d2y3za_: 2y3z A: [170580] automated match to d1g2ua_ complexed with 2pe, gol, trs |
| Domain d2y40a_: 2y40 A: [170581] automated match to d1g2ua_ complexed with mn |
| Domain d2y40b_: 2y40 B: [170582] automated match to d1g2ua_ complexed with mn |
| Domain d2y41a_: 2y41 A: [170583] automated match to d1g2ua_ complexed with ipm, mn |
| Domain d2y41b_: 2y41 B: [170584] automated match to d1g2ua_ complexed with ipm, mn |
| Domain d2y42a_: 2y42 A: [170585] automated match to d1g2ua_ complexed with bcn, mn, nad |
| Domain d2y42b_: 2y42 B: [170586] automated match to d1g2ua_ complexed with bcn, mn, nad |
| Domain d2y42c_: 2y42 C: [170587] automated match to d1g2ua_ complexed with bcn, mn, nad |
| Domain d2y42d_: 2y42 D: [170588] automated match to d1g2ua_ complexed with bcn, mn, nad |
| Domain d2ztwa_: 2ztw A: [171518] automated match to d1g2ua_ complexed with dei, mg, nad |
| Thermus thermophilus [TaxId:300852] [192453] (1 PDB entry) |
| Domain d4f7ia_: 4f7i A: [192421] automated match to d1xaaa_ complexed with eoh, gol, ipm, k, mn, mpo, nad |
| Domain d4f7ib_: 4f7i B: [192422] automated match to d1xaaa_ complexed with eoh, gol, ipm, k, mn, mpo, nad |
| Domain d4f7ic_: 4f7i C: [192423] automated match to d1xaaa_ complexed with eoh, gol, ipm, k, mn, mpo, nad |
| Domain d4f7id_: 4f7i D: [192424] automated match to d1xaaa_ complexed with eoh, gol, ipm, k, mn, mpo, nad |
Timeline for Protein automated matches from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases: