SCOPe 2.03: Domain d2cmva_: 2cmv A:

Lineage for d2cmva_ (2cmv A:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein automated matches [190072] (18 species)
   not a true protein

7. Species Mouse (Mus musculus) [TaxId:10090] [187557] (2 PDB entries)

8. Domain d2cmva_: 2cmv A: [163454]
   automated match to d1t09a_
   complexed with cd, flc, nap

Details for d2cmva_

PDB Entry: 2cmv, 2.52 Å

PDB Description: crystal structure of mouse cytosolic isocitrate dehydrogenase complexed with cadmium and citrate

PDB Compounds: (A:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d2cmva_:

Sequence; same for both SEQRES and ATOM records:

>d2cmva_ c.77.1.1 (A:) automated matches {Mouse (Mus musculus) [TaxId: 10090]}
kiqggsvvemqgdemtriiwelikeklilpyveldlhsydlgienrdatndqvtkdaaea
ikkynvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvtg
wvkpiiigrhaygdqyratdfvvpgpgkveitytpkdgtqkvtymvhdfeegggvamgmy
nqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkkyksqfeaqn
icyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlicpdgktv
eaeaahgtvtrhyrmyqkgqetstnpiasifawsrglahrakldnntelsffakaledvc
ietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkaklaqak

Timeline for d2cmva_:

• d2cmva_ first appeared in SCOPe 2.01
  
• d2cmva_ appears in SCOPe 2.02
  
• d2cmva_ appears in SCOPe 2.04
  
• d2cmva_ last appears in SCOPe 2.07