Class b: All beta proteins [48724] (149 folds) |
Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily) barrel, closed; n=6, S=8; greek-key duplication: consists of two domains of the same fold |
Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families) |
Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins) |
Protein Thrombin [50531] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [50532] (157 PDB entries) |
Domain d1a2c.1: 1a2c L:,H: [26123] complexed with na, oar, oph, rph |
Domain d1a3b.1: 1a3b L:,H: [26084] complexed with t29 |
Domain d1a3e.1: 1a3e L:,H: [26086] complexed with t16 |
Domain d1a46.1: 1a46 L:,H: [26108] complexed with bcy, na, oho, rng |
Domain d1a4w.1: 1a4w L:,H: [26083] complexed with 2ep, ans, kth, na |
Domain d1a5g.1: 1a5g L:,H: [26112] complexed with bic, eoa, na |
Domain d1a61.1: 1a61 L:,H: [26122] complexed with lom, mol, na |
Domain d1abi.1: 1abi L:,H: [26137] |
Domain d1abj.1: 1abj L:,H: [26161] complexed with ch2 |
Domain d1ad8.1: 1ad8 L:,H: [26114] complexed with mdl, na |
Domain d1ae8.1: 1ae8 L:,H: [26101] complexed with azl, nag |
Domain d1afe.1: 1afe L:,H: [26110] complexed with alz, nag |
Domain d1aht.1: 1aht L:,H: [26079] complexed with apa, sfo |
Domain d1ai8.1: 1ai8 L:,H: [26087] complexed with t42 |
Domain d1aix.1: 1aix L:,H: [26113] complexed with t19 |
Domain d1awf.1: 1awf L:,H: [26141] complexed with gr4 |
Domain d1awh.1: 1awh A:,B: [26191] |
Domain d1awh.2: 1awh C:,D: [26192] complexed with gr3 |
Domain d1ay6.1: 1ay6 L:,H: [26088] complexed with hho, hmf |
Domain d1b5g.1: 1b5g L:,H: [26109] complexed with bcc, na, thz |
Domain d1b7x.1: 1b7x A:,B: [26153] mutant |
Domain d1ba8.1: 1ba8 A:,B: [26085] complexed with nag, pms, ron |
Domain d1bb0.1: 1bb0 A:,B: [26106] complexed with 3ga, na, pms, ron |
Domain d1bcu.1: 1bcu L:,H: [26107] complexed with prl |
Domain d1bhx.1: 1bhx A:,B:,F: [26143] complexed with r56 |
Domain d1bmm.1: 1bmm L:,H: [26169] complexed with bm2 |
Domain d1bmn.1: 1bmn L:,H: [26168] complexed with bm9 |
Domain d1c1u.1: 1c1u L:,H: [26091] complexed with bai, na, zn |
Domain d1c1v.1: 1c1v L:,H: [26121] complexed with bab, na, zn |
Domain d1c1w.1: 1c1w L:,H: [26104] complexed with bah, na, zn |
Domain d1c4u.1: 1c4u 1:,2: [26134] complexed with ih1, na |
Domain d1c4v.1: 1c4v 1:,2: [26145] complexed with ih2, na |
Domain d1c4y.1: 1c4y 1:,2: [26172] complexed with ih3 |
Domain d1c5l.1: 1c5l L:,H: [26078] complexed with ca, na |
Domain d1c5n.1: 1c5n L:,H: [26080] complexed with ca, esi, na |
Domain d1c5o.1: 1c5o L:,H: [26097] complexed with bam, na |
Domain d1ca8.1: 1ca8 A:,B: [26120] complexed with 3ga, na, pms, ron |
Domain d1d3d.1: 1d3d A:,B: [26103] complexed with bzt, na, nag |
Domain d1d3p.1: 1d3p A:,B: [26117] complexed with bt3, na, nag |
Domain d1d3q.1: 1d3q A:,B: [26176] complexed with bt2, na, nag |
Domain d1d3t.1: 1d3t A:,B: [26177] complexed with bt1, na, nag |
Domain d1d4p.1: 1d4p A:,B: [26119] complexed with bpp, na, nag |
Domain d1d6wa_: 1d6w A: [26098] complexed with aim, hmm, na, sml |
Domain d1d9ia_: 1d9i A: [26159] complexed with chn, hmm, na, sml |
Domain d1de7.1: 1de7 L:,H: [26095] |
Domain d1de7.2: 1de7 J:,K: [26096] complexed with ch2, na |
Domain d1dit.1: 1dit L:,H: [26136] complexed with 2pp, cbx |
Domain d1dm4.1: 1dm4 A:,B: [26171] |
Domain d1doja_: 1doj A: [26081] complexed with ar2, ch3, na, nag |
Domain d1dwb.1: 1dwb L:,H: [26180] complexed with ben |
Domain d1dwc.1: 1dwc L:,H: [26167] complexed with mit |
Domain d1dwd.1: 1dwd L:,H: [26179] complexed with mid |
Domain d1dwe.1: 1dwe L:,H: [26173] complexed with ch2 |
Domain d1dx5.1: 1dx5 A:,M: [26155] Other proteins in same PDB: d1dx5i1, d1dx5i2, d1dx5i3, d1dx5j1, d1dx5j2, d1dx5j3, d1dx5k1, d1dx5k2, d1dx5k3, d1dx5l1, d1dx5l2, d1dx5l3 |
Domain d1dx5.2: 1dx5 B:,N: [26156] Other proteins in same PDB: d1dx5i1, d1dx5i2, d1dx5i3, d1dx5j1, d1dx5j2, d1dx5j3, d1dx5k1, d1dx5k2, d1dx5k3, d1dx5l1, d1dx5l2, d1dx5l3 |
Domain d1dx5.3: 1dx5 C:,O: [26157] Other proteins in same PDB: d1dx5i1, d1dx5i2, d1dx5i3, d1dx5j1, d1dx5j2, d1dx5j3, d1dx5k1, d1dx5k2, d1dx5k3, d1dx5l1, d1dx5l2, d1dx5l3 |
Domain d1dx5.4: 1dx5 D:,P: [26158] Other proteins in same PDB: d1dx5i1, d1dx5i2, d1dx5i3, d1dx5j1, d1dx5j2, d1dx5j3, d1dx5k1, d1dx5k2, d1dx5k3, d1dx5l1, d1dx5l2, d1dx5l3 complexed with ca, fmt, na, nag; mutant |
Domain d1e0f.1: 1e0f A:,D: [26184] Other proteins in same PDB: d1e0fi_, d1e0fj_, d1e0fk_ |
Domain d1e0f.2: 1e0f B:,E: [26185] Other proteins in same PDB: d1e0fi_, d1e0fj_, d1e0fk_ |
Domain d1e0f.3: 1e0f C:,F: [26186] Other proteins in same PDB: d1e0fi_, d1e0fj_, d1e0fk_ |
Domain d1eb1.1: 1eb1 L:,H: [64892] complexed with alc, mmo, pro |
Domain d1eoja_: 1eoj A: [26105] complexed with bbs, cpi, doa |
Domain d1eola_: 1eol A: [26126] complexed with bbs, cpi, doa |
Domain d1fpc.1: 1fpc L:,H: [26132] complexed with ans, epi, so3 |
Domain d1fph.1: 1fph L:,H: [26160] complexed with ch2 |
Domain d1g30.1: 1g30 A:,B: [65119] complexed with t87 |
Domain d1g32.1: 1g32 A:,B: [65120] complexed with r11 |
Domain d1g37a_: 1g37 A: [60234] complexed with 110 |
Domain d1ghv.1: 1ghv L:,H: [65202] complexed with 120, na |
Domain d1ghw.1: 1ghw L:,H: [65203] complexed with bmz, his, na |
Domain d1ghx.1: 1ghx L:,H: [65204] complexed with bmz, ca, na, zn |
Domain d1ghy.1: 1ghy L:,H: [65205] complexed with 121, ca, na, zn |
Domain d1gj4.1: 1gj4 L:,H: [70177] complexed with 132, na, sty |
Domain d1gj5.1: 1gj5 L:,H: [70178] complexed with 130, na, sty |
Domain d1h8d.1: 1h8d L:,H: [60737] complexed with phw |
Domain d1h8i.1: 1h8i L:,H: [60778] complexed with phw |
Domain d1hage_: 1hag E: [26135] prethrombin 2 complexed with nag, sfo |
Domain d1hah.1: 1hah L:,H: [26125] complexed with nag, sfo |
Domain d1hai.1: 1hai L:,H: [26146] complexed with ch2, nag |
Domain d1hao.1: 1hao L:,H: [26188] protein/DNA complex; complexed with ch2 |
Domain d1hap.1: 1hap L:,H: [26187] protein/DNA complex; complexed with ch2 |
Domain d1hbt.1: 1hbt L:,H: [26093] complexed with chx, paa |
Domain d1hdt.1: 1hdt L:,H: [26183] complexed with alg, ch3, so3 |
Domain d1hgt.1: 1hgt L:,H: [26150] complexed with sfn |
Domain d1hlt.1: 1hlt L:,H: [26181] |
Domain d1hlt.2: 1hlt J:,K: [26182] complexed with ch2 |
Domain d1hut.1: 1hut L:,H: [26189] protein/DNA complex; complexed with ch2 |
Domain d1hxe.1: 1hxe L:,H: [26116] complexed with rb |
Domain d1hxf.1: 1hxf L:,H: [26115] |
Domain d1ihs.1: 1ihs L:,H: [26092] complexed with pnl |
Domain d1iht.1: 1iht L:,H: [26094] complexed with fbe, ptl |
Domain d1jmo.1: 1jmo L:,H: [77137] Other proteins in same PDB: d1jmoa_ complex with a heparin cofactor II mutant |
Domain d1jou.1: 1jou A:,B: [63218] |
Domain d1jou.2: 1jou C:,D: [63219] |
Domain d1jou.3: 1jou E:,F: [63220] complexed with acy, gol, na, nag; mutant |
Domain d1jwta_: 1jwt A: [67398] complexed with bli |
Domain d1k21.1: 1k21 L:,H: [72000] complexed with ign, na, nag, tys |
Domain d1k22.1: 1k22 L:,H: [72001] complexed with mel, na, nag, tys |
Domain d1kts.1: 1kts A:,B: [68865] complexed with c24 |
Domain d1ktt.1: 1ktt A:,B: [68866] complexed with c02 |
Domain d1lhc.1: 1lhc L:,H: [26100] complexed with dp7 |
Domain d1lhd.1: 1lhd L:,H: [26162] complexed with di2 |
Domain d1lhe.1: 1lhe L:,H: [26148] complexed with di3 |
Domain d1lhf.1: 1lhf L:,H: [26166] complexed with di4 |
Domain d1lhg.1: 1lhg L:,H: [26149] complexed with di5 |
Domain d1mh0a_: 1mh0 A: [79110] |
Domain d1mh0b_: 1mh0 B: [79111] anticoagulant slow form complexed with nag; mutant |
Domain d1mu6.1: 1mu6 A:,B: [91462] complexed with cda |
Domain d1mu8.1: 1mu8 A:,B: [91463] complexed with cdb |
Domain d1mue.1: 1mue A:,B: [91464] complexed with cdd |
Domain d1nm6a_: 1nm6 A: [91973] complexed with l86 |
Domain d1no9.1: 1no9 L:,H: [92019] complexed with 4nd, nag |
Domain d1nrn.1: 1nrn L:,H: [26190] |
Domain d1nro.1: 1nro L:,H: [26196] |
Domain d1nrp.1: 1nrp L:,H: [26195] |
Domain d1nrq.1: 1nrq L:,H: [26197] |
Domain d1nrr.1: 1nrr L:,H: [26147] complexed with ch2 |
Domain d1nrs.1: 1nrs L:,H: [26154] complexed with sfn |
Domain d1nt1a_: 1nt1 A: [92101] complexed with t76 |
Domain d1nu7.1: 1nu7 A:,B: [92189] Other proteins in same PDB: d1nu7d1, d1nu7d2, d1nu7h1, d1nu7h2 |
Domain d1nu7.2: 1nu7 E:,F: [92190] Other proteins in same PDB: d1nu7d1, d1nu7d2, d1nu7h1, d1nu7h2 complexed with hg, imd, mcr |
Domain d1nu9a_: 1nu9 A: [92199] Other proteins in same PDB: d1nu9c1, d1nu9c2, d1nu9f1, d1nu9f2 |
Domain d1nu9d_: 1nu9 D: [92202] Other proteins in same PDB: d1nu9c1, d1nu9c2, d1nu9f1, d1nu9f2 complexed with hg, imd, mcr |
Domain d1ny2.1: 1ny2 1:,2: [86397] complexed with tys |
Domain d1nzq.1: 1nzq L:,H: [92386] complexed with 162, alc, sin, smf |
Domain d1o0d.1: 1o0d L:,H: [92392] complexed with 163, alc, sin, smf |
Domain d1o2g.1: 1o2g L:,H: [86595] complexed with 696, na, sty |
Domain d1o5g.1: 1o5g L:,H: [103889] complexed with ca, cr9, na |
Domain d1ook.1: 1ook A:,B: [87199] Other proteins in same PDB: d1ookg_ complexed with cl, man, nag, tys; mutant |
Domain d1oyt.1: 1oyt L:,H: [87615] complexed with ca, fsn, na, sin |
Domain d1p8v.1: 1p8v B:,C: [87984] Other proteins in same PDB: d1p8va_ complexed with dfp, mes, nag, tys; mutant |
Domain d1ppb.1: 1ppb L:,H: [26089] complexed with ch2 |
Domain d1qbv.1: 1qbv L:,H: [26090] |
Domain d1qhr.1: 1qhr A:,B: [26151] complexed with 157 |
Domain d1qj1.1: 1qj1 A:,B: [26111] complexed with 166 |
Domain d1qj6.1: 1qj6 A:,B: [26144] complexed with 167 |
Domain d1qj7.1: 1qj7 A:,B: [26133] complexed with gr1 |
Domain d1qur.1: 1qur L:,H: [26118] complexed with abu, aph, nas, pip |
Domain d1rd3.1: 1rd3 A:,B: [97302] |
Domain d1rd3.2: 1rd3 C:,D: [97303] complexed with fuc, gol, man, nag, po4; mutant |
Domain d1riw.1: 1riw A:,B:,C: [111819] complexed with na, nag, osc, so4 |
Domain d1sl3a_: 1sl3 A: [105709] complexed with 170 |
Domain d1sr5.1: 1sr5 B:,C: [105951] Other proteins in same PDB: d1sr5a_ complexed with nag, nt1, nt2 |
Domain d1tb6.1: 1tb6 L:,H: [106737] Other proteins in same PDB: d1tb6i_ complexed with fuc, gu0, gu1, gu2, gu3, gu4, gu5, gu6, gu8, gu9, man, mpd, nag; mutant |
Domain d1tbz.1: 1tbz L:,H: [26128] complexed with bot, na |
Domain d1thp.1: 1thp A:,B: [26140] complexed with ch2; mutant |
Domain d1thr.1: 1thr L:,H: [26152] |
Domain d1ths.1: 1ths L:,H: [26130] complexed with chx, sin |
Domain d1tmb.1: 1tmb L:,H: [26138] complexed with aht, sfn |
Domain d1tmt.1: 1tmt L:,H: [26127] complexed with nag |
Domain d1tmu.1: 1tmu L:,H: [26165] complexed with ch2, nag, so3 |
Domain d1tom.1: 1tom L:,H: [26082] complexed with min |
Domain d1tq0.1: 1tq0 A:,B: [107196] |
Domain d1tq0.2: 1tq0 C:,D: [107197] mutant |
Domain d1tq7.1: 1tq7 A:,B: [107203] complexed with ch2, nag, zn; mutant |
Domain d1uma.1: 1uma L:,H: [26102] complexed with in2, nag, sfo |
Domain d1uvs.1: 1uvs L:,H: [26174] complexed with i11 |
Domain d1vr1.1: 1vr1 L:,H: [26099] complexed with sfo |
Domain d1xmn.1: 1xmn A:,B: [115495] |
Domain d1xmn.2: 1xmn C:,D: [115496] |
Domain d1xmn.3: 1xmn E:,F: [115497] |
Domain d1xmn.4: 1xmn G:,H: [115498] complexed with gol, ids, man, na, nag, sgn |
Domain d2hgt.1: 2hgt L:,H: [26142] |
Domain d2hnt.1: 2hnt L:,C:,E:,F: [26178] |
Domain d2hpp.1: 2hpp L:,H: [26194] Other proteins in same PDB: d2hppp_ complexed with ch2 |
Domain d2hpq.1: 2hpq L:,H: [26193] Other proteins in same PDB: d2hpqp_ complexed with ch2 |
Domain d2thf.1: 2thf A:,B: [26139] complexed with ch2, na; mutant |
Domain d3hat.1: 3hat L:,H: [26163] complexed with rng, so3 |
Domain d3htc.1: 3htc L:,H: [26175] Other proteins in same PDB: d3htci_ CA-atoms only |
Domain d4htc.1: 4htc L:,H: [26164] Other proteins in same PDB: d4htci_ complexed with nag |
Domain d4thn.1: 4thn L:,H: [26170] complexed with nag, nal |
Domain d5gds.1: 5gds L:,H: [26131] complexed with nag, nal |
Domain d7kme.1: 7kme L:,H: [26124] complexed with na |
Domain d8kme.1: 8kme 1:,2: [26129] complexed with cuc, na |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from b.47.1.2 Thrombin: