Class a: All alpha proteins [46456] (171 folds) |
Fold a.26: 4-helical cytokines [47265] (1 superfamily) core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections |
Superfamily a.26.1: 4-helical cytokines [47266] (3 families) there are two different topoisomers of this fold with different entanglments of the two crossover connections |
Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (7 proteins) contains an additional helix in one of the crossover connections |
Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species) intertwined dimer, similar to interferon-gamma |
Species Human (Homo sapiens) [TaxId:9606] [47307] (5 PDB entries) |
Domain d1ilk__: 1ilk - [16886] |
Domain d1inr__: 1inr - [16887] |
Domain d1j7vl_: 1j7v L: [62704] Other proteins in same PDB: d1j7vr1, d1j7vr2 complexed with IL-10 receptor 1 (IL-10R1) mutant |
Domain d2ilk__: 2ilk - [16885] complexed with so4 |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.3 Interleukin-10 (cytokine synthesis inhibitory factor, CSIF):