Lineage for Species: Human (Homo sapiens)

  1. Root: SCOP 1.65
  2. 275720Class a: All alpha proteins [46456] (179 folds)
  3. 280090Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 280091Superfamily a.26.1: 4-helical cytokines [47266] (3 families) (S)
    there are two different topoisomers of this fold with different entanglments of the two crossover connections
  5. 280231Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (8 proteins)
    contains an additional helix in one of the crossover connections
  6. 280278Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
    intertwined dimer, similar to interferon-gamma
  7. 280281Species Human (Homo sapiens) [TaxId:9606] [47307] (5 PDB entries)

PDB entries in Species: Human (Homo sapiens):

  1. Domain(s) for 1ilk:
  2. Domain(s) for 1inr:
  3. Domain(s) for 1j7v:
  4. Domain(s) for 1lk3:
    1. 280284Domain d1lk3a_: 1lk3 A: [73950]
      Other proteins in same PDB: d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l1, d1lk3l2, d1lk3m1, d1lk3m2
    2. 280285Domain d1lk3b_: 1lk3 B: [73951]
      Other proteins in same PDB: d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l1, d1lk3l2, d1lk3m1, d1lk3m2
  5. Domain(s) for 2ilk:

More info for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.3 Interleukin-10 (cytokine synthesis inhibitory factor, CSIF)

Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.3 Interleukin-10 (cytokine synthesis inhibitory factor, CSIF):