Lineage for Protein: Interleukin-10 (cytokine synthesis inhibitory factor, CSIF)

  1. Root: SCOP 1.63
  2. 208553Class a: All alpha proteins [46456] (171 folds)
  3. 212476Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 212477Superfamily a.26.1: 4-helical cytokines [47266] (3 families) (S)
    there are two different topoisomers of this fold with different entanglments of the two crossover connections
  5. 212614Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (7 proteins)
    contains an additional helix in one of the crossover connections
  6. 212661Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
    intertwined dimer, similar to interferon-gamma

Species:

  1. 212662Epstein-Barr virus [TaxId:10376] [47308] (1 PDB entry)
  2. 212664Human (Homo sapiens) [TaxId:9606] [47307] (5 PDB entries)
    1. Domain for 1ilk:
    2. Domain for 1inr:
    3. Domain for 1j7v:
    4. Domains for 1lk3:
      1. 212667Domain d1lk3a_: 1lk3 A: [73950]
        Other proteins in same PDB: d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l1, d1lk3l2, d1lk3m1, d1lk3m2
      2. 212668Domain d1lk3b_: 1lk3 B: [73951]
        Other proteins in same PDB: d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l1, d1lk3l2, d1lk3m1, d1lk3m2
    5. Domain for 2ilk:
  3. 212671Human herpesvirus 5 [TaxId:10359] [74708] (1 PDB entry)

More info for Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) from a.26.1.3: Interferons/interleukin-10 (IL-10)

Timeline for Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) from a.26.1.3: Interferons/interleukin-10 (IL-10):