SCOPe 2.02: Protein: Lactate dehydrogenase

Lineage for Protein: Lactate dehydrogenase

Root: SCOPe 2.02
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)
Family c.2.1.5: LDH N-terminal domain-like [51848] (8 proteins)
Protein Lactate dehydrogenase [51859] (14 species)

Species:

Bacillus stearothermophilus [TaxId:1422] [51864] (3 PDB entries)
1. Domains for 1ldb:
  1. Domain d1ldba1: 1ldb A:15-162 [30174]
    Other proteins in same PDB: d1ldba2, d1ldbb2, d1ldbc2, d1ldbd2
    complexed with so4
  2. Domain d1ldbb1: 1ldb B:15-162 [118523]
    Other proteins in same PDB: d1ldba2, d1ldbb2, d1ldbc2, d1ldbd2
    duplicate of 1LDB 15-162
    complexed with so4
  3. Domain d1ldbc1: 1ldb C:15-162 [118525]
    Other proteins in same PDB: d1ldba2, d1ldbb2, d1ldbc2, d1ldbd2
    duplicate of 1LDB 15-162
    complexed with so4
  4. Domain d1ldbd1: 1ldb D:15-162 [118527]
    Other proteins in same PDB: d1ldba2, d1ldbb2, d1ldbc2, d1ldbd2
    duplicate of 1LDB 15-162
    complexed with so4
2. Domains for 1ldn:
  1. Domain d1ldna1: 1ldn A:15-162 [30166]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
  2. Domain d1ldnb1: 1ldn B:15-162 [30167]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
  3. Domain d1ldnc1: 1ldn C:15-162 [30168]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
  4. Domain d1ldnd1: 1ldn D:15-162 [30169]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
  5. Domain d1ldne1: 1ldn E:15-162 [30170]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
  6. Domain d1ldnf1: 1ldn F:15-162 [30171]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
  7. Domain d1ldng1: 1ldn G:15-162 [30172]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
  8. Domain d1ldnh1: 1ldn H:15-162 [30173]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
3. Domains for 2ldb:
  1. Domain d2ldba1: 2ldb A:15-162 [30175]
    Other proteins in same PDB: d2ldba2, d2ldbb2, d2ldbc2, d2ldbd2
    complexed with fbp, nad, so4
  2. Domain d2ldbb1: 2ldb B:15-162 [118636]
    Other proteins in same PDB: d2ldba2, d2ldbb2, d2ldbc2, d2ldbd2
    duplicate of 2LDB 15-162
    complexed with fbp, nad, so4
  3. Domain d2ldbc1: 2ldb C:15-162 [118638]
    Other proteins in same PDB: d2ldba2, d2ldbb2, d2ldbc2, d2ldbd2
    duplicate of 2LDB 15-162
    complexed with fbp, nad, so4
  4. Domain d2ldbd1: 2ldb D:15-162 [118640]
    Other proteins in same PDB: d2ldba2, d2ldbb2, d2ldbc2, d2ldbd2
    duplicate of 2LDB 15-162
    complexed with fbp, nad, so4
Bifidobacterium longum, strain am101-2 [TaxId:216816] [51866] (2 PDB entries)
1. Domains for 1lld:
  1. Domain d1llda1: 1lld A:7-149 [30177]
    Other proteins in same PDB: d1llda2, d1lldb2
    complexed with nad
  2. Domain d1lldb1: 1lld B:7-149 [30178]
    Other proteins in same PDB: d1llda2, d1lldb2
    complexed with nad
2. Domains for 1lth:
  1. Domain d1lthr1: 1lth R:7-149 [30179]
    Other proteins in same PDB: d1lthr2, d1ltht2
    complexed with fbp, nad, oxm
  2. Domain d1ltht1: 1lth T:7-149 [30180]
    Other proteins in same PDB: d1lthr2, d1ltht2
    complexed with fbp, nad, oxm
Clostridium thermocellum [TaxId:1515] [117432] (1 PDB entry)
Uniprot Q4CDK5
- Domain for 1y6j:
  - Domain d1y6ja1: 1y6j A:7-148 [116507]
    Other proteins in same PDB: d1y6ja2
    Structural genomics target
Dogfish (Squalus acanthias) [TaxId:7797] [51862] (3 PDB entries)
1. Domain for 1ldm:
  - Domain d1ldma1: 1ldm A:1-160 [30160]
    Other proteins in same PDB: d1ldma2
    complexed with nad, oxm
2. Domain for 6ldh:
  - Domain d6ldha1: 6ldh A:1-160 [30161]
    Other proteins in same PDB: d6ldha2
    complexed with so4
3. Domain for 8ldh:
  - Domain d8ldha1: 8ldh A:1-160 [30162]
    Other proteins in same PDB: d8ldha2
    complexed with cit
Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [63939] (2 PDB entries)
1. Domains for 1i0z:
  1. Domain d1i0za1: 1i0z A:1-160 [61495]
    Other proteins in same PDB: d1i0za2, d1i0zb2
    complexed with nai, oxm
  2. Domain d1i0zb1: 1i0z B:1-160 [61497]
    Other proteins in same PDB: d1i0za2, d1i0zb2
    complexed with nai, oxm
2. Domains for 1t2f:
  1. Domain d1t2fa1: 1t2f A:1-160 [99088]
    Other proteins in same PDB: d1t2fa2, d1t2fb2, d1t2fc2, d1t2fd2
    complexed with nad, oxq
  2. Domain d1t2fb1: 1t2f B:1-160 [99090]
    Other proteins in same PDB: d1t2fa2, d1t2fb2, d1t2fc2, d1t2fd2
    complexed with nad, oxq
  3. Domain d1t2fc1: 1t2f C:1-160 [99092]
    Other proteins in same PDB: d1t2fa2, d1t2fb2, d1t2fc2, d1t2fd2
    complexed with nad, oxq
  4. Domain d1t2fd1: 1t2f D:1-160 [99094]
    Other proteins in same PDB: d1t2fa2, d1t2fb2, d1t2fc2, d1t2fd2
    complexed with nad, oxq
Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [63940] (1 PDB entry)
- Domains for 1i10:
  1. Domain d1i10a1: 1i10 A:1-159 [61499]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
  2. Domain d1i10b1: 1i10 B:1-159 [61501]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
  3. Domain d1i10c1: 1i10 C:1-159 [61503]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
  4. Domain d1i10d1: 1i10 D:1-159 [61505]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
  5. Domain d1i10e1: 1i10 E:1-159 [61507]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
  6. Domain d1i10f1: 1i10 F:1-159 [61509]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
  7. Domain d1i10g1: 1i10 G:1-159 [61511]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
  8. Domain d1i10h1: 1i10 H:1-159 [61513]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
Lactobacillus casei [TaxId:1582] [51865] (1 PDB entry)
- Domain for 1llc:
  - Domain d1llca1: 1llc A:13-164 [30176]
    Other proteins in same PDB: d1llca2
    complexed with afp, so4
Lactobacillus pentosus [TaxId:1589] [69418] (1 PDB entry)
- Domains for 1ez4:
  1. Domain d1ez4a1: 1ez4 A:16-162 [64917]
    Other proteins in same PDB: d1ez4a2, d1ez4b2, d1ez4c2, d1ez4d2
    complexed with nad
  2. Domain d1ez4b1: 1ez4 B:16-162 [64919]
    Other proteins in same PDB: d1ez4a2, d1ez4b2, d1ez4c2, d1ez4d2
    complexed with nad
  3. Domain d1ez4c1: 1ez4 C:16-162 [64921]
    Other proteins in same PDB: d1ez4a2, d1ez4b2, d1ez4c2, d1ez4d2
    complexed with nad
  4. Domain d1ez4d1: 1ez4 D:16-162 [64923]
    Other proteins in same PDB: d1ez4a2, d1ez4b2, d1ez4c2, d1ez4d2
    complexed with nad
Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51863] (15 PDB entries)
1. Domain for 1ceq:
  - Domain d1ceqa1: 1ceq A:19-163 [30163]
    Other proteins in same PDB: d1ceqa2
2. Domain for 1cet:
  - Domain d1ceta1: 1cet A:18-163 [30164]
    Other proteins in same PDB: d1ceta2
    complexed with clq
3. Domain for 1ldg:
  - Domain d1ldga1: 1ldg A:18-163 [30165]
    Other proteins in same PDB: d1ldga2
    complexed with nad, oxm
4. Domain for 1t24:
  - Domain d1t24a1: 1t24 A:18-163 [99069]
    Other proteins in same PDB: d1t24a2
    complexed with gol, nad, oxq
5. Domain for 1t25:
  - Domain d1t25a1: 1t25 A:18-163 [99071]
    Other proteins in same PDB: d1t25a2
    complexed with gag, gol, nai
6. Domain for 1t26:
  - Domain d1t26a1: 1t26 A:19-163 [99073]
    Other proteins in same PDB: d1t26a2
    complexed with gbd, nai
7. Domain for 1t2c:
  - Domain d1t2ca1: 1t2c A:18-163 [99082]
    Other proteins in same PDB: d1t2ca2
    complexed with gol, nai
8. Domain for 1t2d:
  - Domain d1t2da1: 1t2d A:1-150 [99084]
    Other proteins in same PDB: d1t2da2
    complexed with gol, nad, oxl
9. Domain for 1t2e:
  - Domain d1t2ea1: 1t2e A:18-163 [99086]
    Other proteins in same PDB: d1t2ea2
    complexed with gol, nai, oxm; mutant
10. Domain for 1u4o:
  - Domain d1u4oa1: 1u4o A:18-163 [119527]
    Other proteins in same PDB: d1u4oa2
    automatically matched to d1oc4a1
    complexed with mpd, ndd
11. Domain for 1u4s:
  - Domain d1u4sa1: 1u4s A:18-163 [119529]
    Other proteins in same PDB: d1u4sa2
    automatically matched to d1oc4a1
    complexed with bih
12. Domain for 1u5a:
  - Domain d1u5aa1: 1u5a A:18-163 [119532]
    Other proteins in same PDB: d1u5aa2
    automatically matched to d1oc4a1
    complexed with bik
13. Domain for 1u5c:
  - Domain d1u5ca1: 1u5c A:18-163 [119534]
    Other proteins in same PDB: d1u5ca2
    automatically matched to d1oc4a1
    complexed with bik, nad
14. Domain for 1xiv:
  - Domain d1xiva1: 1xiv A:18-163 [122018]
    Other proteins in same PDB: d1xiva2
    automatically matched to d1oc4a1
    complexed with gol, rb2
15. Domain for 2a94:
  - Domain d2a94a1: 2a94 A:18-163 [126423]
    Other proteins in same PDB: d2a94a2
    automatically matched to d1oc4a1
    complexed with ap0
Mouse (Mus musculus) [TaxId:10090] [51861] (1 PDB entry)
- Domains for 2ldx:
  1. Domain d2ldxa1: 2ldx A:1-159 [30159]
    Other proteins in same PDB: d2ldxa2, d2ldxb2, d2ldxc2, d2ldxd2
  2. Domain d2ldxb1: 2ldx B:1-159 [118642]
    Other proteins in same PDB: d2ldxa2, d2ldxb2, d2ldxc2, d2ldxd2
    duplicate of 2LDX 1-159
  3. Domain d2ldxc1: 2ldx C:1-159 [118644]
    Other proteins in same PDB: d2ldxa2, d2ldxb2, d2ldxc2, d2ldxd2
    duplicate of 2LDX 1-159
  4. Domain d2ldxd1: 2ldx D:1-159 [118646]
    Other proteins in same PDB: d2ldxa2, d2ldxb2, d2ldxc2, d2ldxd2
    duplicate of 2LDX 1-159
Pig (Sus scrofa) [TaxId:9823] [51860] (3 PDB entries)
1. Domain for 5ldh:
  - Domain d5ldha1: 5ldh A:1-162 [30158]
    Other proteins in same PDB: d5ldha2
    complexed with cit, lnc
2. Domains for 9ldb:
  1. Domain d9ldba1: 9ldb A:1-162 [30156]
    Other proteins in same PDB: d9ldba2, d9ldbb2
    complexed with nad, oxm, so4
  2. Domain d9ldbb1: 9ldb B:1-162 [30157]
    Other proteins in same PDB: d9ldba2, d9ldbb2
    complexed with nad, oxm, so4
3. Domains for 9ldt:
  1. Domain d9ldta1: 9ldt A:1-162 [30154]
    Other proteins in same PDB: d9ldta2, d9ldtb2
    complexed with nad, oxm, so4
  2. Domain d9ldtb1: 9ldt B:1-162 [30155]
    Other proteins in same PDB: d9ldta2, d9ldtb2
    complexed with nad, oxm, so4
Plasmodium berghei [TaxId:5821] [102165] (1 PDB entry)
- Domains for 1oc4:
  1. Domain d1oc4a1: 1oc4 A:18-163 [92770]
    Other proteins in same PDB: d1oc4a2, d1oc4b2
    complexed with gol, nad, oxm
  2. Domain d1oc4b1: 1oc4 B:18-163 [92772]
    Other proteins in same PDB: d1oc4a2, d1oc4b2
    complexed with gol, nad, oxm
Thermotoga maritima [TaxId:2336] [51867] (1 PDB entry)
- Domain for 1a5z:
  - Domain d1a5za1: 1a5z A:22-163 [30181]
    Other proteins in same PDB: d1a5za2
    complexed with cd, fbp, nad, oxm
Toxoplasma gondii [TaxId:5811] [102166] (4 PDB entries)
1. Domain for 1pze:
  - Domain d1pzea1: 1pze A:14-163 [95415]
    Other proteins in same PDB: d1pzea2
2. Domains for 1pzf:
  1. Domain d1pzfa1: 1pzf A:14-163 [95417]
    Other proteins in same PDB: d1pzfa2, d1pzfb2, d1pzfc2, d1pzfd2
    complexed with a3d, oxl
  2. Domain d1pzfb1: 1pzf B:14-163 [95419]
    Other proteins in same PDB: d1pzfa2, d1pzfb2, d1pzfc2, d1pzfd2
    complexed with a3d, oxl
  3. Domain d1pzfc1: 1pzf C:14-163 [95421]
    Other proteins in same PDB: d1pzfa2, d1pzfb2, d1pzfc2, d1pzfd2
    complexed with a3d, oxl
  4. Domain d1pzfd1: 1pzf D:14-163 [95423]
    Other proteins in same PDB: d1pzfa2, d1pzfb2, d1pzfc2, d1pzfd2
    complexed with a3d, oxl
3. Domains for 1pzg:
  1. Domain d1pzga1: 1pzg A:14-163 [95425]
    Other proteins in same PDB: d1pzga2, d1pzgb2, d1pzgc2, d1pzgd2
    complexed with a3d, so4
  2. Domain d1pzgb1: 1pzg B:14-163 [95427]
    Other proteins in same PDB: d1pzga2, d1pzgb2, d1pzgc2, d1pzgd2
    complexed with a3d, so4
  3. Domain d1pzgc1: 1pzg C:15-163 [95429]
    Other proteins in same PDB: d1pzga2, d1pzgb2, d1pzgc2, d1pzgd2
    complexed with a3d, so4
  4. Domain d1pzgd1: 1pzg D:14-163 [95431]
    Other proteins in same PDB: d1pzga2, d1pzgb2, d1pzgc2, d1pzgd2
    complexed with a3d, so4
4. Domains for 1pzh:
  1. Domain d1pzha1: 1pzh A:14-163 [95433]
    Other proteins in same PDB: d1pzha2, d1pzhb2, d1pzhc2, d1pzhd2
    complexed with nad, oxl
  2. Domain d1pzhb1: 1pzh B:14-163 [95435]
    Other proteins in same PDB: d1pzha2, d1pzhb2, d1pzhc2, d1pzhd2
    complexed with nad, oxl
  3. Domain d1pzhc1: 1pzh C:14-163 [95437]
    Other proteins in same PDB: d1pzha2, d1pzhb2, d1pzhc2, d1pzhd2
    complexed with nad, oxl
  4. Domain d1pzhd1: 1pzh D:14-163 [95439]
    Other proteins in same PDB: d1pzha2, d1pzhb2, d1pzhc2, d1pzhd2
    complexed with nad, oxl

More info for Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like

Timeline for Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like:

Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like first appeared (with stable ids) in SCOP 1.55, called Protein Lactate dehydrogenase from c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain
Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like appears in SCOPe 2.01
Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like appears in SCOPe 2.03
Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like appears in the current release, SCOPe 2.08