SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Welcome to SCOPe!

SCOPe (Structural Classification of Proteins — extended) is a database developed at the Berkeley Lab and UC Berkeley to extend the development and maintenance of SCOP. SCOP was conceived at the MRC Laboratory of Molecular Biology, and developed in collaboration with researchers in Berkeley. Work on SCOP (version 1) concluded in June 2009 with the release of SCOP 1.75.

SCOPe classifies many newer structures through a combination of automation and manual curation, and corrects some errors in SCOP, aiming to have the same accuracy as the hand-curated SCOP releases. SCOPe also incorporates and updates the Astral database.


Classes in SCOPe 2.06:

  1. 1976409a: All alpha proteins [46456] (289 folds)
  2. 2017114b: All beta proteins [48724] (177 folds)
  3. 2078559c: Alpha and beta proteins (a/b) [51349] (148 folds)
  4. 2152203d: Alpha and beta proteins (a+b) [53931] (385 folds)
  5. 2217451e: Multi-domain proteins (alpha and beta) [56572] (69 folds)
  6. 2223823f: Membrane and cell surface proteins and peptides [56835] (59 folds)
  7. 2229111g: Small proteins [56992] (94 folds)
  8. 2237529h: Coiled coil proteins [57942] (7 folds)
  9. 2240115i: Low resolution protein structures [58117] (25 folds)
  10. 2243222j: Peptides [58231] (133 folds)
  11. 2245226k: Designed proteins [58788] (44 folds)
  12. 2245868l: Artifacts [310555] (1 fold)