SCOPe: Structural Classification of Proteins — extended. Release 2.08 (updated 2026-08-16, stable release September 2021)

Welcome to SCOPe!

SCOPe (Structural Classification of Proteins — extended) is a database developed at the Berkeley Lab and UC Berkeley to extend the development and maintenance of SCOP. SCOP was conceived at the MRC Laboratory of Molecular Biology, and developed in collaboration with researchers in Berkeley. Work on SCOP (version 1) concluded in June 2009 with the release of SCOP 1.75.

SCOPe classifies many newer structures through a combination of automation and manual curation, and corrects some errors in SCOP, aiming to have the same accuracy as the hand-curated SCOP releases. SCOPe also incorporates and updates the Astral database.
About SCOPe Stats & Prior Releases

News

2026-09-12: SCOPe now offers a REST API and public MCP service for agent-assisted research, alongside human AlphaFold comparisons. Learn how to connect your assistant, retrieve evidence, and find research skills and how to explore AlphaFold models matched to classified domains
2026-08-16: New pdb entries were added in a periodic update; for more info on these updates, see the periodic update documentation.
2026-05-14: The server now uses Anubis to block LLM scrapers and other bots that have made the site increasingly unusable over the past several years. If this causes problems for real use, please email us.
2022-01-07: We published a paper describing the new features in SCOPe 2.08-stable. [SCOPe 2.08 paper (PDF)].
2021-09-20: SCOPe 2.08-stable has been released, with nearly 20,000 new pdb entries added since the last stable release. Important features include genetic variant search tools and annotations of structural heterogeneity and repeat units. Select either the About SCOPe or SCOPe statistics and history link for more details on what's new!

Classes in SCOPe 2.08:

a: All alpha proteins [46456] (290 folds)
b: All beta proteins [48724] (180 folds)
c: Alpha and beta proteins (a/b) [51349] (148 folds)
d: Alpha and beta proteins (a+b) [53931] (396 folds)
e: Multi-domain proteins (alpha and beta) [56572] (74 folds)
f: Membrane and cell surface proteins and peptides [56835] (69 folds)
g: Small proteins [56992] (100 folds)
h: Coiled coil proteins [57942] (7 folds)
i: Low resolution protein structures [58117] (25 folds)
j: Peptides [58231] (151 folds)
k: Designed proteins [58788] (44 folds)
l: Artifacts [310555] (1 fold)