Lineage for Family b.1.1.1: V set domains (antibody variable domain-like)

  1. Root: SCOP 1.67
  2. 362614Class b: All beta proteins [48724] (141 folds)
  3. 362615Fold b.1: Immunoglobulin-like beta-sandwich [48725] (22 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 362616Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 362617Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (24 proteins)

Proteins:

  1. 362618Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), N-terminal domain [81942] (1 species)
  2. 362621Camelid IG heavy chain variable domain, VHh [88563] (2 species)
    1. 362622Species Camel (Camelus dromedarius) [TaxId:9838] [88564] (12 PDB entries)
    2. 362649Species Llama (Lama glama) [TaxId:9844] [88565] (6 PDB entries)
  3. 362657CD2, first domain [48740] (2 species)
    1. 362658Species Human (Homo sapiens) [TaxId:9606] [48741] (4 PDB entries)
    2. 362664Species Rat (Rattus norvegicus) [TaxId:10116] [48742] (5 PDB entries)
  4. 362677CD2-binding domain of CD58, N-terminal domain [48743] (1 species)
  5. 362683CD4 V-set domains [48737] (2 species)
    1. 362684Species Human (Homo sapiens) [TaxId:9606] [48738] (15 PDB entries)
    2. 362709Species Rat (Rattus rattus) [TaxId:10117] [48739] (1 PDB entry)
  6. 362711CD8 [48734] (2 species)
    1. 362712Species Human (Homo sapiens) [TaxId:9606] [48735] (2 PDB entries)
    2. 362716Species Mouse (Mus musculus) [TaxId:10090] [48736] (2 PDB entries)
  7. 362723CD80, N-terminal domain [48745] (1 species)
    a soluble form of b7-1
  8. 362728CD86 (b7-2), N-terminal domain [63635] (1 species)
  9. 362734Coxsackie virus and adenovirus receptor (Car), domain 1 [48730] (1 species)
  10. 362744HSV glycoprotein D [63637] (1 species)
  11. 362751Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
    1. 362752Species Engineered (including hybrid species) [88562] (28 PDB entries)
    2. 362799Species Hamster (Cricetulus griseus) [TaxId:10029] [88561] (1 PDB entry)
    3. 362802Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88544] (16 PDB entries)
    4. 362831Species Human (Homo sapiens), cluster 2.1 [TaxId:9606] [88545] (3 PDB entries)
    5. 362837Species Human (Homo sapiens), cluster 2.2 [TaxId:9606] [88546] (1 PDB entry)
    6. 362839Species Human (Homo sapiens), cluster 3 [TaxId:9606] [88547] (11 PDB entries)
    7. 362855Species Human (Homo sapiens), cluster 4 [TaxId:9606] [101505] (1 PDB entry)
    8. 362858Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (41 PDB entries)
    9. 362910Species Mouse (Mus musculus), cluster 2.1 [TaxId:10090] [88549] (16 PDB entries)
    10. 362934Species Mouse (Mus musculus), cluster 2.2 [TaxId:10090] [88550] (47 PDB entries)
    11. 363002Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] [88551] (28 PDB entries)
    12. 363037Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (141 PDB entries)
    13. 363222Species Mouse (Mus musculus), cluster 3.3 [TaxId:10090] [88553] (1 PDB entry)
    14. 363225Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88554] (29 PDB entries)
    15. 363265Species Mouse (Mus musculus), cluster 5 [TaxId:10090] [88555] (35 PDB entries)
    16. 363311Species Mouse (Mus musculus), cluster 6 [TaxId:10090] [88556] (11 PDB entries)
    17. 363325Species Mouse (Mus musculus), cluster 7.1 [TaxId:10090] [88557] (33 PDB entries)
    18. 363365Species Mouse (Mus musculus), cluster 7.2 [TaxId:10090] [88558] (20 PDB entries)
    19. 363388Species Mouse (Mus musculus), cluster 7.3 [TaxId:10090] [88559] (2 PDB entries)
    20. 363391Species Rat (Rattus norvegicus) [TaxId:10116] [88560] (14 PDB entries)
  12. 363425Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
    1. 363426Species Engineered (including hybrid species) [88533] (27 PDB entries)
    2. 363471Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88520] (19 PDB entries)
    3. 363515Species Human (Homo sapiens), cluster 2 [TaxId:9606] [88521] (10 PDB entries)
    4. 363531Species Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88522] (5 PDB entries)
    5. 363541Species Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88523] (7 PDB entries)
    6. 363551Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (121 PDB entries)
    7. 363702Species Mouse (Mus musculus), cluster 1.2 [TaxId:10090] [88525] (34 PDB entries)
    8. 363752Species Mouse (Mus musculus), cluster 2 [TaxId:10090] [88526] (24 PDB entries)
    9. 363785Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] [88527] (12 PDB entries)
    10. 363802Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88528] (18 PDB entries)
    11. 363828Species Mouse (Mus musculus), cluster 3.3 [TaxId:10090] [88529] (2 PDB entries)
    12. 363832Species Mouse (Mus musculus), cluster 3.4 [TaxId:10090] [88530] (3 PDB entries)
    13. 363836Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (160 PDB entries)
    14. 364043Species Rat (Rattus norvegicus) [TaxId:10116] [88532] (7 PDB entries)
  13. 364057Immunoglobulin light chain lambda variable domain, VL-lambda [88534] (9 species)
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
    1. 364058Species Hamster (Cricetulus griseus) [TaxId:10029] [88542] (1 PDB entry)
    2. 364061Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88535] (2 PDB entries)
    3. 364066Species Human (Homo sapiens), cluster 2 [TaxId:9606] [88536] (9 PDB entries)
    4. 364080Species Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88537] (1 PDB entry)
    5. 364082Species Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88538] (1 PDB entry)
    6. 364084Species Human (Homo sapiens), cluster 4 [TaxId:9606] [88539] (23 PDB entries)
    7. 364130Species Human (Homo sapiens), cluster 5 [TaxId:9606] [88540] (3 PDB entries)
    8. 364136Species Mouse (Mus musculus) [TaxId:10090] [88541] (33 PDB entries)
    9. 364181Species Rat (Rattus norvegicus) [TaxId:10116] [101504] (7 PDB entries)
  14. 364202Immunoreceptor CTLA-4 (CD152), N-terminal fragment [48939] (2 species)
    1. 364203Species Human (Homo sapiens) [TaxId:9606] [48940] (3 PDB entries)
    2. 364209Species Mouse (Mus musculus) [TaxId:10090] [48941] (1 PDB entry)
  15. 364214Junction adhesion molecule, JAM, N-terminal domain [48747] (2 species)
    1. 364215Species Human (Homo sapiens) [TaxId:9606] [89180] (1 PDB entry)
    2. 364218Species Mouse (Mus musculus) [TaxId:10090] [48748] (1 PDB entry)
  16. 364220Myelin membrane adhesion molecule P0 [48728] (1 species)
  17. 364223Myelin oligodendrocyte glycoprotein (MOG) [89174] (1 species)
  18. 364229N-terminal domain of sialic acid binding Ig-like lectin 7 (SIGLEC-7, p75/AIRM1) [89176] (1 species)
  19. 364234N-terminal domain of sialoadhesin [48732] (1 species)
  20. 364243NK cell activating receptor NKP44 [89178] (1 species)
    a triggering partner in natural cytotoxicity
  21. 364246Programmed cell death protein 1, PD1, extracellular domain [101510] (1 species)
  22. 364249T-cell antigen receptor [48933] (6 species)
    sequences may differ within each classified species
    1. 364250Species Human (Homo sapiens), alpha-chain [TaxId:9606] [48935] (10 PDB entries)
    2. 364261Species Human (Homo sapiens), beta-chain [TaxId:9606] [48937] (11 PDB entries)
    3. 364274Species Human (Homo sapiens), delta-chain [TaxId:9606] [48938] (2 PDB entries)
    4. 364281Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63651] (1 PDB entry)
    5. 364286Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [48934] (16 PDB entries)
    6. 364315Species Mouse (Mus musculus), beta-chain [TaxId:10090] [48936] (17 PDB entries)
  23. 364344TREM-1 (triggering receptor expressed on myeloid cells 1) [101506] (1 species)
  24. 364350Tyrosine-protein kinase receptor tyro3, N-terminal domain [101508] (1 species)

More info for Family b.1.1.1: V set domains (antibody variable domain-like)

Timeline for Family b.1.1.1: V set domains (antibody variable domain-like):