Lineage for Class b: All beta proteins

  1. Root: SCOP 1.67
  2. 362614Class b: All beta proteins [48724] (141 folds)

Folds:

  1. 362615b.1: Immunoglobulin-like beta-sandwich [48725] (22 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  2. 368237b.2: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (8 superfamilies)
    sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
  3. 368613b.3: Prealbumin-like [49451] (6 superfamilies)
    sandwich; 7 strands in 2 sheets, greek-key
    variations: some members have additional 1-2 strands to common fold
  4. 369090b.4: HSP40/DnaJ peptide-binding domain [49492] (1 superfamily)
    sandwich; 6 strands in 2 sheets
  5. 369101b.5: alpha-Amylase inhibitor tendamistat [49497] (1 superfamily)
    sandwich; 6 strands in 2 sheets
  6. 369112b.6: Cupredoxin-like [49502] (2 superfamilies)
    sandwich; 7 strands in 2 sheets, greek-key
    variations: some members have additional 1-2 strands
  7. 369767b.7: C2 domain-like [49561] (4 superfamilies)
    sandwich; 8 strands in 2 sheets; greek-key
  8. 369911b.8: TRAF domain-like [49598] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key
  9. 369982b.9: Neurophysin II [49605] (1 superfamily)
    sandwich; 8 strands in 2 sheets; meander
  10. 369998b.11: gamma-Crystallin-like [49694] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key
    duplication: has internal pseudo twofold symmetry
  11. 370096b.12: Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1 superfamily)
    sandwich; 8 strands in 2 sheets; complex topology
    duplication: has weak internal pseudo twofold symmetry
  12. 370155b.14: Calpain large subunit, middle domain (domain III) [49757] (1 superfamily)
    sandwich; 8 strands in 2 sheets; jelly-roll
  13. 370167b.15: HSP20-like chaperones [49763] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key
  14. 370194b.16: Ecotin, trypsin inhibitor [49771] (1 superfamily)
    sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
  15. 370218b.17: PEBP-like [49776] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
  16. 370246b.18: Galactose-binding domain-like [49784] (1 superfamily)
    sandwich; 9 strands in 2 sheets; jelly-roll
  17. 370579b.19: Viral protein domain [49817] (1 superfamily)
    sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
  18. 370725b.20: ENV polyprotein, receptor-binding domain [49829] (1 superfamily)
    sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
  19. 370735b.21: Virus attachment protein globular domain [49834] (1 superfamily)
    sandwich, 10 strands in 2 sheets; greek-key
  20. 370769b.22: TNF-like [49841] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  21. 370923b.23: CUB-like [49853] (2 superfamilies)
    sandwich, 10 strands in 2 sheets; jelly-roll
  22. 370953b.24: Hyaluronate lyase-like, C-terminal domain [49862] (1 superfamily)
    sandwich, 10 strands in 2 sheets; "folded meander"
  23. 370997b.25: Osmotin, thaumatin-like protein [49869] (1 superfamily)
    sandwich; 11 strands in 2 sheets
  24. 371023b.26: SMAD/FHA domain [49878] (1 superfamily)
    sandwich; 11 strands in 2 sheets; greek-key
  25. 371102b.27: Soluble secreted chemokine inhibitor, VCCI [49888] (1 superfamily)
    sandwich; 11 strands in 2 sheets; greek-key
  26. 371109b.28: Baculovirus p35 protein [49893] (1 superfamily)
    sandwich; 14 strands in 2 sheets; greek-key
  27. 371122b.29: Concanavalin A-like lectins/glucanases [49898] (1 superfamily)
    sandwich; 12-14 strands in 2 sheets; complex topology
  28. 372004b.30: Supersandwich [49993] (3 superfamilies)
    sandwich; 18 strands in 2 sheets
  29. 372340b.31: EV matrix protein [50011] (1 superfamily)
    consists of two beta-sandwich domains of similar topologies
  30. 372350b.32: gp9 [50016] (1 superfamily)
    consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
  31. 372359b.33: ISP domain [50021] (1 superfamily)
    consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
  32. 372425b.34: SH3-like barrel [50036] (15 superfamilies)
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
  33. 373088b.35: GroES-like [50128] (2 superfamilies)
    contains barrel, partly opened; n*=4, S*=8; meander
  34. 373409b.36: PDZ domain-like [50155] (1 superfamily)
    contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
  35. 373584b.37: N-terminal domains of the minor coat protein g3p [50175] (1 superfamily)
    core: barrel, in some members open; n*=4, S*=8; meander
  36. 373598b.38: Sm-like fold [50181] (2 superfamilies)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology
  37. 373873b.39: Ribosomal protein L14 [50192] (1 superfamily)
    barrel, closed; n=5, S=8, meander
  38. 373898b.40: OB-fold [50198] (10 superfamilies)
    barrel, closed or partly opened n=5, S=10 or S=8; greek-key
  39. 375249b.41: PRC-barrel domain [50345] (1 superfamily)
    core: barrel, partly opened; n*=5, S*=8; meander
  40. 375317b.42: beta-Trefoil [50352] (6 superfamilies)
    barrel, closed; n=6, S=12; and a hairpin triplet; meander
    duplication: has internal pseudo threefold symmetry
  41. 375649b.43: Reductase/isomerase/elongation factor common domain [50412] (4 superfamilies)
    barrel, closed; n=6, S=10; greek-key
  42. 375902b.44: Elongation factor/aminomethyltransferase common domain [50464] (2 superfamilies)
    barrel, closed; n=6, S=10; greek-key
  43. 375965b.45: FMN-binding split barrel [50474] (1 superfamily)
    barrel; n=6, S=10; greek-key
  44. 376020b.46: FMT C-terminal domain-like [50485] (1 superfamily)
    barrel, open; n*=6, S*=10; greek-key
  45. 376039b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  46. 377213b.48: mu transposase, C-terminal domain [50609] (1 superfamily)
    barrel; n=6, S=8, greek-key
  47. 377221b.49: Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (3 superfamilies)
    barrel, closed; n=6, S=8; greek-key
  48. 377363b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  49. 377961b.51: ValRS/IleRS/LeuRS editing domain [50676] (1 superfamily)
    core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
  50. 377990b.52: Double psi beta-barrel [50684] (2 superfamilies)
    barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
  51. 378122b.53: Ribosomal protein L25-like [50714] (1 superfamily)
    barrel, closed; n=6, S=10; complex topology
  52. 378150b.54: Core binding factor beta, CBF [50722] (1 superfamily)
    barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
  53. 378166b.55: PH domain-like [50728] (1 superfamily)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  54. 378383b.56: Transcription factor IIA (TFIIA), beta-barrel domain [50783] (1 superfamily)
    barrel, closed; n=6, S=12; mixed beta-sheet
  55. 378398b.57: Herpes virus serine proteinase, assemblin [50788] (1 superfamily)
    core: barrel, closed; n=7, S=8; complex topology
  56. 378454b.58: PK beta-barrel domain-like [50799] (1 superfamily)
    barrel, closed; n=7, S=10; complex topology
  57. 378559b.59: XRCC4, N-terminal domain [50808] (1 superfamily)
    barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
  58. 378568b.60: Lipocalins [50813] (1 superfamily)
    barrel, closed or opened; n=8, S=12; meander
  59. 378912b.61: Streptavidin-like [50875] (6 superfamilies)
    barrel, closed; n=8, S=10; meander
  60. 379249b.62: Cyclophilin (peptidylprolyl isomerase) [50890] (1 superfamily)
    barrel, closed; n=8, S=10; complex topology
  61. 379388b.63: Oncogene products [50903] (1 superfamily)
    barrel, closed; n=8, S=10; one overside connection
  62. 379402b.64: Mannose 6-phosphate receptor domain [50910] (1 superfamily)
    barrel, partly open; n*=8, S*=10; one psi loop
  63. 379421b.65: triple barrel [50915] (1 superfamily)
    dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
  64. 379436b.66: 4-bladed beta-propeller [50922] (1 superfamily)
    consists of four 4-stranded beta-sheet motifs; meander
  65. 379465b.67: 5-bladed beta-propeller [50933] (3 superfamilies)
    consists of five 4-stranded beta-sheet motifs; meander
  66. 379505b.68: 6-bladed beta-propeller [50938] (10 superfamilies)
    consists of six 4-stranded beta-sheet motifs; meander
  67. 379749b.69: 7-bladed beta-propeller [50964] (12 superfamilies)
    consists of seven 4-stranded beta-sheet motifs; meander
  68. 379960b.70: 8-bladed beta-propeller [50997] (3 superfamilies)
    consists of eight 4-stranded beta-sheet motifs; meander
    also found in some members of the WD40-repeat superfamily
  69. 380059b.71: Glycosyl hydrolase domain [51010] (1 superfamily)
    folded sheet; greek-key
  70. 380372b.72: WW domain-like [51044] (3 superfamilies)
    core: 3-stranded meander beta-sheet
  71. 380449b.73: Head domain of nucleotide exchange factor GrpE [51063] (1 superfamily)
    small mixed beta-sheet, 4 "generalized" strands
  72. 380456b.74: Carbonic anhydrase [51068] (1 superfamily)
    single sheet; 10 strands
  73. 380666b.75: Bacteriochlorophyll A protein [51080] (1 superfamily)
    single sheet; 16 strands; meander
  74. 380677b.76: open-sided beta-meander [51086] (2 superfamilies)
    single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
  75. 380700b.77: beta-Prism I [51091] (3 superfamilies)
    consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
    duplication: has internal pseudo threefold symmetry
  76. 380788b.78: beta-Prism II [51109] (1 superfamily)
    consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
    duplication: consists of two domains of this fold
  77. 380828b.80: Single-stranded right-handed beta-helix [51125] (7 superfamilies)
    superhelix turns are made of parallel beta-strands and (short) turns
  78. 381026b.81: Single-stranded left-handed beta-helix [51160] (3 superfamilies)
    superhelix turns are made of parallel beta-strands and (short) turns
  79. 381159b.82: Double-stranded beta-helix [51181] (7 superfamilies)
    one turn of helix is made by two pairs of antiparallel strands linked with short turns
    has appearance of a sandwich of distinct architecture and jelly-roll topology
  80. 381743b.83: Triple beta-spiral [51224] (1 superfamily)
    trimer formed by the interlocking beta-hairpin repeat units
  81. 381760b.84: Barrel-sandwich hybrid [51229] (3 superfamilies)
    sandwich of half-barrel shaped beta-sheets
  82. 381897b.85: beta-clip [51268] (7 superfamilies)
    double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
  83. 382110b.86: Hedgehog/intein (Hint) domain [51293] (1 superfamily)
    complex fold made of five beta-hairpin units and a b-ribbon arc
  84. 382138b.87: LexA/Signal peptidase [51305] (1 superfamily)
    complex fold made of several coiled beta-sheets; contains an SH3-like barrel
  85. 382181b.88: Mss4-like [51315] (1 superfamily)
    complex fold made of several coiled beta-sheets
  86. 382200b.89: Cyanovirin-N [51321] (1 superfamily)
    complex fold
  87. 382221b.90: Head-binding domain of phage P22 tailspike protein [51326] (1 superfamily)
    complex fold made of bifurcated and partly folded beta-sheet
  88. 382232b.91: E2 regulatory, transactivation domain [51331] (1 superfamily)
    complex fold made of bifurcated and coiled beta-sheets
  89. 382243b.92: Composite domain of metallo-dependent hydrolases [51337] (1 superfamily)
    pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
  90. 382366b.93: Epsilon subunit of F1F0-ATP synthase N-terminal domain [51343] (1 superfamily)
    pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
  91. 382378b.94: Olfactory marker protein [63696] (1 superfamily)
    sandwich; 8 strands in 2 sheets; jelly-roll
  92. 382390b.95: Ganglioside M2 (gm2) activator [63706] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
  93. 382398b.96: Nicotinic receptor ligand binding domain-like [63711] (1 superfamily)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
  94. 382448b.97: Anemone pore-forming cytolysin [63723] (1 superfamily)
    sandwich, 10 strands in 2 sheets;
  95. 382464b.98: Leukotriene A4 hydrolase N-terminal domain [63736] (1 superfamily)
    duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
  96. 382472b.100: Sortase [63816] (1 superfamily)
    barrel, closed; n=8, S=10; mixed sheet; two overside connections
  97. 382485b.101: Ribonuclease domain of colicin E3 [63839] (1 superfamily)
    twisted meander beta-sheet of 6 strands
  98. 382493b.102: Methuselah ectodomain [63876] (1 superfamily)
    complex fold
  99. 382500b.103: Molybdenum cofactor biosynthesis protein MoeA, N-terminal and linker domains [63881] (1 superfamily)
    complex fold made of bifurcated and coiled b-sheets
  100. 382513b.104: P-domain of calnexin/calreticulin [63886] (1 superfamily)
    non-globular proline-rich hairpin
  101. 382524b.105: Penicillin-binding protein 5, C-terminal domain [69188] (1 superfamily)
    sandwich; 6 strands in 2 sheets
  102. 382533b.106: Phage tail proteins [69278] (1 superfamily)
    core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
  103. 382544b.107: Urease metallochaperone UreE, N-terminal domain [69286] (1 superfamily)
    barrel, closed; n=6, S=8; a crossover loop topology
  104. 382562b.108: Triple-stranded beta-helix [69348] (1 superfamily)
    (homo)trimer; each chain donates 3 beta-strands per turn of the helix
  105. 382572b.109: beta-hairpin stack [69359] (1 superfamily)
    Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
  106. 382591b.110: Cloacin translocation domain [69368] (1 superfamily)
    complex fold made of several coiled beta-sheets
  107. 382601b.111: Small protein B (SmpB) [74981] (1 superfamily)
    barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
  108. 382611b.112: C-terminal domain of mollusc hemocyanin [81278] (1 superfamily)
    six-stranded beta-sandwich, jelly-roll/greek-key topology
  109. 382622b.113: N-terminal domain of MutM-like DNA repair proteins [81625] (1 superfamily)
    pseudobarrel; capped on both ends by alpha-helices
  110. 382650b.114: N-utilization substance G protein NusG, insert domain [82003] (1 superfamily)
    sandwich; 8 strands in 2 sheets; meander
  111. 382665b.115: Calcium-mediated lectin [82025] (1 superfamily)
    sandwich; 9 strands in 2 sheets; greek-key
  112. 382695b.116: Viral chemokine binding protein m3 [82045] (1 superfamily)
    consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
  113. 382703b.117: Obg-fold [82050] (1 superfamily)
    this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
    these regions form six left-handed collagen-like helices packed and H-bonded together
  114. 382712b.118: FAS1 domain [82152] (1 superfamily)
    core: barrel, closed; n=7, S=12; meander
  115. 382722b.119: C-terminal autoproteolytic domain of nucleoporin nup98 [82214] (1 superfamily)
    multisheet protein with a mixture of beta-sandwich and beta-prism features
  116. 382729b.120: Tp47 lipoprotein, N-terminal domain [82219] (1 superfamily)
    complex fold; consists of two intertwined subdomains
  117. 382736b.121: Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7 superfamilies)
    sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
    characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
  118. 383312b.122: PUA domain-like [88696] (1 superfamily)
    pseudobarrel; mixed folded sheet of 5 strands; order 13452; strand 1 and 3 are parallel to each other
  119. 383379b.123: Hypothetical protein TM1070 [89231] (1 superfamily)
    sandwich; 8 strands in 2 sheets; jelly-roll
  120. 383388b.124: HesB-like domain [89359] (1 superfamily)
    barrel, closed; n=7, S=10; complex topology
  121. 383400b.125: Lipoprotein localization factors LolAB [89391] (1 superfamily)
    11 stranded sheet partly folded in a corner-like structure filled with a few short helices
  122. 383413b.126: Adsorption protein p2 [89427] (1 superfamily)
    multisheet protein containing partial beta-propeller and beta-sandwich regions
  123. 383420b.127: Baseplate structural protein gp8 [89432] (1 superfamily)
    multisheet protein with a mixture of beta-sandwich and beta-barrel features
  124. 383437b.128: Hypothetical protein YojF [89441] (1 superfamily)
    pseudobarrel; capped at one end by an alpha-helix
  125. 383443b.129: MazE/MraZ-like [89446] (1 superfamily)
    pseudobarrel; capped on both ends by alpha-helices
  126. 383472b.130: Heat shock protein 70kD (HSP70), peptide-binding domain [100919] (1 superfamily)
    beta-sandwich: 8 strands in 2 sheets
  127. 383488b.131: SPOC domain-like [100938] (1 superfamily)
    barrel, closed; n=7, S=10; complex topology
  128. 383504b.132: Supernatant protein factor (SPF), C-terminal domain [101575] (1 superfamily)
    sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
  129. 383512b.133: Dextranase, N-terminal domain [101595] (1 superfamily)
    sandwich; 9 strands in 2 sheets; greek-key
  130. 383519b.134: Unnamed hypothetical protein [101600] (1 superfamily)
    sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
  131. 383525b.135: Superantigen (mitogen) Ypm [101605] (1 superfamily)
    sandwich; 9 strands in 2 sheets; jelly-roll
  132. 383534b.136: Stringent starvation protein B, SspB [101737] (1 superfamily)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
  133. 383557b.137: RNase P subunit p29-like [101743] (1 superfamily)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
  134. 383566b.138: Hydrophobin II, HfbII [101750] (1 superfamily)
    core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
  135. 383573b.139: Surface presentation of antigens (SPOA) [101800] (1 superfamily)
    segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
  136. 383586b.140: Replicase NSP9 [101815] (1 superfamily)
    barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
  137. 383594b.141: Bacterial fluorinating enzyme, C-terminal domain [101851] (1 superfamily)
    barrel, closed; n=7, S=10; greek-key topology; one overside connection
  138. 383605b.142: Type II restriction endonuclease effector domain [101935] (1 superfamily)
    core: twisted 7-stranded beta-sheet (half-barrel) of complex topology
  139. 383612b.143: NAC domain [101940] (1 superfamily)
    core: twisted 7-stranded beta-sheet (half-barrel)
  140. 383621b.144: Trimeric adhesin [101998] (1 superfamily)
    trimer; contains two different beta-prism-like domains connected by an linker subdomain of less regular structure
  141. 383632b.145: AXH domain [102030] (1 superfamily)
    pseudobarrel; some similarity to OB-fold

More info for Class b: All beta proteins

Timeline for Class b: All beta proteins: