Lineage for Protein: Immunoglobulin light chain lambda variable domain, VL-lambda

  1. Root: SCOP 1.67
  2. 362614Class b: All beta proteins [48724] (141 folds)
  3. 362615Fold b.1: Immunoglobulin-like beta-sandwich [48725] (22 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 362616Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 362617Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (24 proteins)
  6. 364057Protein Immunoglobulin light chain lambda variable domain, VL-lambda [88534] (9 species)
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family

Species:

  1. 364058Hamster (Cricetulus griseus) [TaxId:10029] [88542] (1 PDB entry)
  2. 364061Human (Homo sapiens), cluster 1 [TaxId:9606] [88535] (2 PDB entries)
    1. Domains for 1cd0:
      1. 364062Domain d1cd0a_: 1cd0 A: [20559]
      2. 364063Domain d1cd0b_: 1cd0 B: [20560]
        VL dimer of Bence-Jones protein JTO
    2. Domains for 2cd0:
      1. 364064Domain d2cd0a_: 2cd0 A: [20561]
      2. 364065Domain d2cd0b_: 2cd0 B: [20562]
        VL dimer of Bence-Jones protein WIL
  3. 364066Human (Homo sapiens), cluster 2 [TaxId:9606] [88536] (9 PDB entries)
    1. Domains for 1bjm:
      1. 364070Domain d1bjma1: 1bjm A:1-111 [20524]
        Other proteins in same PDB: d1bjma2, d1bjmb2
      2. 364071Domain d1bjmb1: 1bjm B:1-111 [20525]
        Other proteins in same PDB: d1bjma2, d1bjmb2
        VL dimer of Bence-Jones protein LOC
    2. Domain for 1nl0:
    3. Domains for 1q1j:
      1. 364077Domain d1q1jl1: 1q1j L:1-108 [95585]
        Other proteins in same PDB: d1q1jh1, d1q1jh2, d1q1ji1, d1q1ji2, d1q1jl2, d1q1jm2
      2. 364078Domain d1q1jm1: 1q1j M:1-108 [95587]
        Other proteins in same PDB: d1q1jh1, d1q1jh2, d1q1ji1, d1q1ji2, d1q1jl2, d1q1jm2
        part of anti HIV-1 Fab 447-52d
    4. Domain for 1rzf:
    5. Domain for 2fb4:
    6. Domain for 2ig2:
    7. Domain for 2rhe:
    8. Domains for 3bjl:
      1. 364073Domain d3bjla1: 3bjl A:1-111 [20526]
        Other proteins in same PDB: d3bjla2, d3bjlb2
      2. 364074Domain d3bjlb1: 3bjl B:1-111 [20527]
        Other proteins in same PDB: d3bjla2, d3bjlb2
        VL dimer of Bence-Jones protein LOC
    9. Domains for 4bjl:
      1. 364075Domain d4bjla1: 4bjl A:1-111 [20528]
        Other proteins in same PDB: d4bjla2, d4bjlb2
      2. 364076Domain d4bjlb1: 4bjl B:1-111 [20529]
        Other proteins in same PDB: d4bjla2, d4bjlb2
        VL dimer of Bence-Jones protein LOC
  4. 364080Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88537] (1 PDB entry)
  5. 364082Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88538] (1 PDB entry)
  6. 364084Human (Homo sapiens), cluster 4 [TaxId:9606] [88539] (23 PDB entries)
    1. Domains for 1a8j:
      1. 364123Domain d1a8jh1: 1a8j H:1-111 [20598]
        Other proteins in same PDB: d1a8jh2, d1a8jl2
        part of the antibody MCG light chain dimer
        complexed with pme
      2. 364124Domain d1a8jl1: 1a8j L:1-111 [20597]
        Other proteins in same PDB: d1a8jh2, d1a8jl2
    2. Domains for 1dcl:
      1. 364091Domain d1dcla1: 1dcl A:1-111 [20565]
        Other proteins in same PDB: d1dcla2, d1dclb2
      2. 364092Domain d1dclb1: 1dcl B:1-111 [20566]
        Other proteins in same PDB: d1dcla2, d1dclb2
        part of the antibody MCG light chain dimer
    3. Domains for 1jvk:
      1. 364087Domain d1jvka1: 1jvk A:1-112 [71897]
        Other proteins in same PDB: d1jvka2, d1jvkb2
      2. 364088Domain d1jvkb1: 1jvk B:1-112 [71899]
        Other proteins in same PDB: d1jvka2, d1jvkb2
        part of amyloidogenic protein BUR
        complexed with pca
    4. Domains for 1lgv:
      1. 364085Domain d1lgva1: 1lgv A:1-112 [84608]
        Other proteins in same PDB: d1lgva2, d1lgvb2
      2. 364086Domain d1lgvb1: 1lgv B:1-112 [84610]
        Other proteins in same PDB: d1lgva2, d1lgvb2
        part of amyloidogenic protein BUR
        complexed with pca
    5. Domains for 1lhz:
      1. 364089Domain d1lhza1: 1lhz A:1-112 [84612]
        Other proteins in same PDB: d1lhza2, d1lhzb2
      2. 364090Domain d1lhzb1: 1lhz B:1-112 [84614]
        Other proteins in same PDB: d1lhza2, d1lhzb2
        part of amyloidogenic protein BUR
        complexed with pca
    6. Domains for 1mcb:
      1. 364101Domain d1mcba1: 1mcb A:1-111 [20575]
        Other proteins in same PDB: d1mcba2, d1mcbb2
      2. 364102Domain d1mcbb1: 1mcb B:1-111 [20576]
        Other proteins in same PDB: d1mcba2, d1mcbb2
        part of the antibody MCG light chain dimer
    7. Domains for 1mcc:
      1. 364107Domain d1mcca1: 1mcc A:1-111 [20583]
        Other proteins in same PDB: d1mcca2, d1mccb2
      2. 364108Domain d1mccb1: 1mcc B:1-111 [20584]
        Other proteins in same PDB: d1mcca2, d1mccb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    8. Domains for 1mcd:
      1. 364097Domain d1mcda1: 1mcd A:1-111 [20571]
        Other proteins in same PDB: d1mcda2, d1mcdb2
      2. 364098Domain d1mcdb1: 1mcd B:1-111 [20572]
        Other proteins in same PDB: d1mcda2, d1mcdb2
        part of the antibody MCG light chain dimer
        complexed with bal, nh2
    9. Domains for 1mce:
      1. 364111Domain d1mcea1: 1mce A:1-111 [20587]
        Other proteins in same PDB: d1mcea2, d1mceb2
      2. 364112Domain d1mceb1: 1mce B:1-111 [20588]
        Other proteins in same PDB: d1mcea2, d1mceb2
        part of the antibody MCG light chain dimer
        complexed with bal
    10. Domains for 1mcf:
      1. 364103Domain d1mcfa1: 1mcf A:1-111 [20579]
        Other proteins in same PDB: d1mcfa2, d1mcfb2
      2. 364104Domain d1mcfb1: 1mcf B:1-111 [20580]
        Other proteins in same PDB: d1mcfa2, d1mcfb2
        part of the antibody MCG light chain dimer
        complexed with bal
    11. Domains for 1mch:
      1. 364125Domain d1mcha1: 1mch A:1-111 [20599]
        Other proteins in same PDB: d1mcha2, d1mchb2
      2. 364126Domain d1mchb1: 1mch B:1-111 [20600]
        Other proteins in same PDB: d1mcha2, d1mchb2
        part of the antibody MCG light chain dimer
        complexed with bal
    12. Domains for 1mci:
      1. 364109Domain d1mcia1: 1mci A:1-111 [20581]
        Other proteins in same PDB: d1mcia2, d1mcib2
      2. 364110Domain d1mcib1: 1mci B:1-111 [20582]
        Other proteins in same PDB: d1mcia2, d1mcib2
        part of the antibody MCG light chain dimer
    13. Domains for 1mcj:
      1. 364119Domain d1mcja1: 1mcj A:1-111 [20595]
        Other proteins in same PDB: d1mcja2, d1mcjb2
      2. 364120Domain d1mcjb1: 1mcj B:1-111 [20596]
        Other proteins in same PDB: d1mcja2, d1mcjb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    14. Domains for 1mck:
      1. 364099Domain d1mcka1: 1mck A:1-111 [20573]
        Other proteins in same PDB: d1mcka2, d1mckb2
      2. 364100Domain d1mckb1: 1mck B:1-111 [20574]
        Other proteins in same PDB: d1mcka2, d1mckb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    15. Domains for 1mcl:
      1. 364113Domain d1mcla1: 1mcl A:1-111 [20589]
        Other proteins in same PDB: d1mcla2, d1mclb2
      2. 364114Domain d1mclb1: 1mcl B:1-111 [20590]
        Other proteins in same PDB: d1mcla2, d1mclb2
        part of the antibody MCG light chain dimer
    16. Domains for 1mcn:
      1. 364117Domain d1mcna1: 1mcn A:1-111 [20591]
        Other proteins in same PDB: d1mcna2, d1mcnb2
      2. 364118Domain d1mcnb1: 1mcn B:1-111 [20592]
        Other proteins in same PDB: d1mcna2, d1mcnb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    17. Domain for 1mco:
    18. Domains for 1mcq:
      1. 364105Domain d1mcqa1: 1mcq A:1-111 [20577]
        Other proteins in same PDB: d1mcqa2, d1mcqb2
      2. 364106Domain d1mcqb1: 1mcq B:1-111 [20578]
        Other proteins in same PDB: d1mcqa2, d1mcqb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    19. Domains for 1mcr:
      1. 364121Domain d1mcra1: 1mcr A:1-111 [20593]
        Other proteins in same PDB: d1mcra2, d1mcrb2
      2. 364122Domain d1mcrb1: 1mcr B:1-111 [20594]
        Other proteins in same PDB: d1mcra2, d1mcrb2
        part of the antibody MCG light chain dimer
    20. Domains for 1mcs:
      1. 364115Domain d1mcsa1: 1mcs A:1-111 [20585]
        Other proteins in same PDB: d1mcsa2, d1mcsb2
      2. 364116Domain d1mcsb1: 1mcs B:1-111 [20586]
        Other proteins in same PDB: d1mcsa2, d1mcsb2
        part of the antibody MCG light chain dimer
    21. Domains for 1mcw:
      1. 364127Domain d1mcwm1: 1mcw M:1-111 [20601]
        Other proteins in same PDB: d1mcwm2, d1mcww2
      2. 364128Domain d1mcww1: 1mcw W:1-111 [20602]
        Other proteins in same PDB: d1mcwm2, d1mcww2
        part of heterologous L chain dimer MCG-WEIR
    22. Domains for 2mcg:
      1. 364093Domain d2mcg11: 2mcg 1:1-111 [20567]
        Other proteins in same PDB: d2mcg12, d2mcg22
      2. 364094Domain d2mcg21: 2mcg 2:1-111 [20568]
        Other proteins in same PDB: d2mcg12, d2mcg22
        part of the antibody MCG light chain dimer
    23. Domains for 3mcg:
      1. 364095Domain d3mcg11: 3mcg 1:1-111 [20569]
        Other proteins in same PDB: d3mcg12, d3mcg22
      2. 364096Domain d3mcg21: 3mcg 2:1-111 [20570]
        Other proteins in same PDB: d3mcg12, d3mcg22
        part of the antibody MCG light chain dimer
  7. 364130Human (Homo sapiens), cluster 5 [TaxId:9606] [88540] (3 PDB entries)
    1. Domain for 1adq:
    2. Domains for 1lil:
      1. 364133Domain d1lila1: 1lil A:2-107 [20557]
        Other proteins in same PDB: d1lila2, d1lilb2
      2. 364134Domain d1lilb1: 1lil B:2-107 [20558]
        Other proteins in same PDB: d1lila2, d1lilb2
        part of Bence-Jones protein CLE
    3. Domains for 8fab:
      1. 364131Domain d8faba1: 8fab A:3-105 [19772]
        Other proteins in same PDB: d8faba2, d8fabb1, d8fabb2, d8fabc2, d8fabd1, d8fabd2
      2. 364132Domain d8fabc1: 8fab C:3-105 [19774]
        Other proteins in same PDB: d8faba2, d8fabb1, d8fabb2, d8fabc2, d8fabd1, d8fabd2
        part of Fab HIL
  8. 364136Mouse (Mus musculus) [TaxId:10090] [88541] (33 PDB entries)
    1. Domain for 1a6u:
    2. Domains for 1a6v:
      1. 364153Domain d1a6vl_: 1a6v L: [20256]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
      2. 364154Domain d1a6vm_: 1a6v M: [20258]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
      3. 364155Domain d1a6vn_: 1a6v N: [20260]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
        part of Fv B1-8
        complexed with npc
    3. Domain for 1a6w:
    4. Domain for 1dl7:
      • 364164Domain d1dl7l_: 1dl7 L: [20498]
        Other proteins in same PDB: d1dl7h_
        part of Fv M3C65; conflict: annotated in PDB as human protein
        complexed with nch
    5. Domains for 1etz:
      1. 364173Domain d1etza1: 1etz A:1-110 [20480]
        Other proteins in same PDB: d1etza2, d1etzb1, d1etzb2, d1etzh1, d1etzh2, d1etzl2
        part of anti-sweetener Fab NC10.14
        complexed with gas
      2. 364174Domain d1etzl1: 1etz L:1-110 [20478]
        Other proteins in same PDB: d1etza2, d1etzb1, d1etzb2, d1etzh1, d1etzh2, d1etzl2
    6. Domain for 1f4w:
    7. Domain for 1f4x:
    8. Domain for 1f4y:
    9. Domain for 1gig:
    10. Domain for 1ind:
    11. Domain for 1ine:
    12. Domain for 1jn6:
    13. Domains for 1jnh:
      1. 364165Domain d1jnha1: 1jnh A:1-108 [66939]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      2. 364166Domain d1jnhc1: 1jnh C:1-108 [66943]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      3. 364167Domain d1jnhe1: 1jnh E:1-108 [66947]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      4. 364168Domain d1jnhg1: 1jnh G:1-108 [66951]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
        part of anti-estradiol Fab 10G6D6
        complexed with eco
    14. Domain for 1mfa:
    15. Domain for 1mfb:
    16. Domain for 1mfc:
    17. Domain for 1mfd:
    18. Domain for 1mfe:
    19. Domains for 1nc2:
      1. 364147Domain d1nc2a1: 1nc2 A:1-110 [91781]
        Other proteins in same PDB: d1nc2a2, d1nc2b1, d1nc2b2, d1nc2c2, d1nc2d1, d1nc2d2
      2. 364148Domain d1nc2c1: 1nc2 C:1-110 [91785]
        Other proteins in same PDB: d1nc2a2, d1nc2b1, d1nc2b2, d1nc2c2, d1nc2d1, d1nc2d2
        part of Fab 2d12.5
        complexed with cl, doe, nag, yt3
    20. Domains for 1nc4:
      1. 364150Domain d1nc4a1: 1nc4 A:1-110 [91789]
        Other proteins in same PDB: d1nc4a2, d1nc4b1, d1nc4b2, d1nc4c2, d1nc4d1, d1nc4d2
      2. 364151Domain d1nc4c1: 1nc4 C:1-110 [91793]
        Other proteins in same PDB: d1nc4a2, d1nc4b1, d1nc4b2, d1nc4c2, d1nc4d1, d1nc4d2
        part of Fab 2d12.5
        complexed with cl, dof, gd3, nag
    21. Domain for 1ngp:
    22. Domain for 1ngq:
    23. Domains for 1nj9:
      1. 364161Domain d1nj9a1: 1nj9 A:1-108 [91897]
        Other proteins in same PDB: d1nj9a2, d1nj9b1, d1nj9b2, d1nj9h1, d1nj9h2, d1nj9l2
      2. 364162Domain d1nj9l1: 1nj9 L:1-108 [91903]
        Other proteins in same PDB: d1nj9a2, d1nj9b1, d1nj9b2, d1nj9h1, d1nj9h2, d1nj9l2
        part of cocaine hydrolytic Fab 15a10
        complexed with na
    24. Domain for 1p4b:
    25. Domain for 1p4i:
    26. Domains for 1pg7:
      1. 364178Domain d1pg7w1: 1pg7 W:1-108 [94682]
        Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l1, d1pg7l2, d1pg7m1, d1pg7m2, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y2, d1pg7z1, d1pg7z2
      2. 364179Domain d1pg7y1: 1pg7 Y:1-108 [94686]
        Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l1, d1pg7l2, d1pg7m1, d1pg7m2, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y2, d1pg7z1, d1pg7z2
        part of Fab 6A6
    27. Domain for 1q0x:
    28. Domain for 1q0y:
    29. Domain for 1sm3:
    30. Domains for 1yuh:
      1. 364176Domain d1yuha1: 1yuh A:2-109 [20098]
        Other proteins in same PDB: d1yuha2, d1yuhb1, d1yuhb2, d1yuhh1, d1yuhh2, d1yuhl2
        part of an anti-nitrophenol Fab
        complexed with np
      2. 364177Domain d1yuhl1: 1yuh L:2-109 [20096]
        Other proteins in same PDB: d1yuha2, d1yuhb1, d1yuhb2, d1yuhh1, d1yuhh2, d1yuhl2
    31. Domain for 2vir:
    32. Domain for 2vis:
    33. Domain for 2vit:
  9. 364181Rat (Rattus norvegicus) [TaxId:10116] [101504] (7 PDB entries)
    1. Domain for 1oaq:
    2. Domains for 1oar:
      1. 364187Domain d1oarl_: 1oar L: [92713]
        Other proteins in same PDB: d1oarh_, d1oari_, d1oarj_, d1oark_
      2. 364188Domain d1oarm_: 1oar M: [92714]
        Other proteins in same PDB: d1oarh_, d1oari_, d1oarj_, d1oark_
      3. 364189Domain d1oarn_: 1oar N: [92715]
        Other proteins in same PDB: d1oarh_, d1oari_, d1oarj_, d1oark_
      4. 364190Domain d1oaro_: 1oar O: [92716]
        Other proteins in same PDB: d1oarh_, d1oari_, d1oarj_, d1oark_
        part of IgE Fv spe-7
        complexed with azn, cac, cl, dms, edo, na
    3. Domains for 1oau:
      1. 364183Domain d1oaul_: 1oau L: [92721]
        Other proteins in same PDB: d1oauh_, d1oaui_, d1oauj_, d1oauk_
      2. 364184Domain d1oaum_: 1oau M: [92722]
        Other proteins in same PDB: d1oauh_, d1oaui_, d1oauj_, d1oauk_
      3. 364185Domain d1oaun_: 1oau N: [92723]
        Other proteins in same PDB: d1oauh_, d1oaui_, d1oauj_, d1oauk_
      4. 364186Domain d1oauo_: 1oau O: [92724]
        Other proteins in same PDB: d1oauh_, d1oaui_, d1oauj_, d1oauk_
        part of IgE Fv spe-7
        complexed with dnf, imd, ser
    4. Domains for 1oax:
      1. 364192Domain d1oaxl_: 1oax L: [92729]
        Other proteins in same PDB: d1oaxh_, d1oaxi_, d1oaxj_, d1oaxk_
      2. 364193Domain d1oaxm_: 1oax M: [92730]
        Other proteins in same PDB: d1oaxh_, d1oaxi_, d1oaxj_, d1oaxk_
      3. 364194Domain d1oaxn_: 1oax N: [92731]
        Other proteins in same PDB: d1oaxh_, d1oaxi_, d1oaxj_, d1oaxk_
      4. 364195Domain d1oaxo_: 1oax O: [92732]
        Other proteins in same PDB: d1oaxh_, d1oaxi_, d1oaxj_, d1oaxk_
        part of IgE Fv spe-7
        complexed with anq
    5. Domains for 1oay:
      1. 364196Domain d1oayl_: 1oay L: [92737]
        Other proteins in same PDB: d1oayh_, d1oayi_, d1oayj_, d1oayk_
      2. 364197Domain d1oaym_: 1oay M: [92738]
        Other proteins in same PDB: d1oayh_, d1oayi_, d1oayj_, d1oayk_
      3. 364198Domain d1oayn_: 1oay N: [92739]
        Other proteins in same PDB: d1oayh_, d1oayi_, d1oayj_, d1oayk_
      4. 364199Domain d1oayo_: 1oay O: [92740]
        Other proteins in same PDB: d1oayh_, d1oayi_, d1oayj_, d1oayk_
        part of IgE Fv spe-7
        complexed with fur
    6. Domains for 1oaz:
      1. 364200Domain d1oazl_: 1oaz L: [92745]
        Other proteins in same PDB: d1oaza_, d1oazb_, d1oazh_, d1oazj_
      2. 364201Domain d1oazn_: 1oaz N: [92746]
        Other proteins in same PDB: d1oaza_, d1oazb_, d1oazh_, d1oazj_
        part of IgE Fv spe-7
    7. Domain for 1ocw:

More info for Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like)

Timeline for Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like):

  • Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like) first appeared in SCOP 1.65
  • Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like) appears in SCOP 1.69
  • Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like) appears in the current release, SCOPe 2.07