SCOP 1.63: Family d.153.1.4: Proteasome subunits

Lineage for Family d.153.1.4: Proteasome subunits

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (5 families)
   N-terminal residue provides two catalytic groups, nucleophile and proton donor

5. Family d.153.1.4: Proteasome subunits [56251] (3 proteins)

Proteins:

1. HslV (ClpQ) protease [56258] (2 species)
   dodecameric prokaryotic homologue of proteasome

   1. Species Escherichia coli [TaxId:562] [56259] (7 PDB entries)

   2. Species Haemophilus influenzae [TaxId:727] [56260] (4 PDB entries)

2. Proteasome alpha subunit (non-catalytic) [56255] (3 species)
   contains an extension to the common fold at the N-teminus

   1. Species Archaeon Thermoplasma acidophilum [TaxId:2303] [56256] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56257] (4 PDB entries)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)

   3. Species Cow (Bos taurus) [TaxId:9913] [75568] (1 PDB entry)

3. Proteasome beta subunit (catalytic) [56252] (3 species)

   1. Species Archaeon Thermoplasma acidophilum [TaxId:2303] [56253] (1 PDB entry)

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56254] (4 PDB entries)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)

   3. Species Cow (Bos taurus) [TaxId:9913] [75567] (1 PDB entry)

More info for Family d.153.1.4: Proteasome subunits

Timeline for Family d.153.1.4: Proteasome subunits:

• Family d.153.1.4: Proteasome subunits first appeared (with stable ids) in SCOP 1.55
  
• Family d.153.1.4: Proteasome subunits appears in SCOP 1.61
  
• Family d.153.1.4: Proteasome subunits appears in SCOP 1.65
  
• Family d.153.1.4: Proteasome subunits appears in the current release, SCOPe 2.08