Lineage for Class d: Alpha and beta proteins (a+b)

  1. Root: SCOP 1.63
  2. 251695Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

Folds:

  1. 251696d.1: Microbial ribonucleases [53932] (1 superfamily)
    single helix packs against antiparallel beta-sheet
  2. 251966d.2: Lysozyme-like [53954] (1 superfamily)
    common alpha+beta motif for the active site region
  3. 252917d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 253179d.4: His-Me finger endonucleases [54059] (1 superfamily)
    core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
  5. 253232d.5: RNase A-like [54075] (1 superfamily)
    contains long curved beta-sheet and 3 helices
  6. 253447d.6: Prion-like [54097] (1 superfamily)
    beta-alpha-beta-alpha(2); antiparallel beta-ribbon
  7. 253482d.7: LysM domain [54105] (1 superfamily)
    beta-alpha(2)-beta; antiparallel strands
  8. 253489d.8: Urease, gamma-subunit [54110] (1 superfamily)
    alpha(3)-beta(2); antiparallel hairpin
  9. 253528d.9: IL8-like [54116] (2 superfamilies)
    beta(3)-alpha
  10. 253732d.10: DNA-binding domain [54170] (1 superfamily)
    beta(3)-alpha; 2 layers: alpha/beta
  11. 253759d.11: Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1 superfamily)
    alpha1-beta3; 2 layers: alpha/beta; order 132
  12. 253778d.12: Ribosomal proteins L23 and L15e [54188] (1 superfamily)
    beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
  13. 253802d.13: HIT-like [54196] (2 superfamilies)
    alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
  14. 253872d.14: Ribosomal protein S5 domain 2-like [54210] (1 superfamily)
    core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
  15. 253998d.15: beta-Grasp (ubiquitin-like) [54235] (10 superfamilies)
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
  16. 254680d.16: FAD-linked reductases, C-terminal domain [54372] (1 superfamily)
    alpha+beta sandwich
  17. 254865d.17: Cystatin-like [54402] (5 superfamilies)
    Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
  18. 255190d.18: ssDNA-binding transcriptional regulator domain [54446] (1 superfamily)
    helix-swapped dimer of beta(4)-alpha motifs
  19. 255210d.19: MHC antigen-recognition domain [54451] (1 superfamily)
    dimeric
  20. 255565d.20: UBC-like [54494] (1 superfamily)
    alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
  21. 255615d.21: Diaminopimelate epimerase [54505] (1 superfamily)
    mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
  22. 255622d.22: GFP-like [54510] (1 superfamily)
    beta-sheet folds into a barrel (n=11, S=14) around the central helix
  23. 255686d.23: Transcriptional factor tubby, C-terminal domain [54517] (1 superfamily)
    beta-sheet folds into a barrel (n=12, S=12) around the central helix
  24. 255693d.24: Pilin [54522] (1 superfamily)
    contains very long N-terminal helix, which end is packed against beta-sheet
  25. 255704d.25: Acidic mitochondrial matrix protein p32 [54528] (1 superfamily)
    core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
  26. 255712d.26: FKBP-like [54533] (3 superfamilies)
    core: beta(2)-alpha-beta(2); antiparallel beta-sheet
  27. 255891d.27: Ribosomal protein S16 [54564] (1 superfamily)
    beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
  28. 255911d.28: Ribosomal protein S19 [54569] (1 superfamily)
    alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
  29. 255932d.29: Ribosomal protein L31e [54574] (1 superfamily)
    beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
  30. 255945d.30: Allophycocyanin linker chain (domain) [54579] (1 superfamily)
    beta(2)-alpha-beta; 2 layers: alpha/beta
  31. 255952d.31: Cdc48 domain 2-like [54584] (1 superfamily)
    beta-alpha-beta(3); 2 layers: alpha/beta
  32. 255972d.32: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1 superfamily)
    beta-alpha-beta(3); 2 layers: alpha/beta
  33. 256110d.33: Bacterial protein-export protein SecB [54610] (1 superfamily)
    beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
  34. 256119d.34: DNA-binding domain of Mlu1-box binding protein MBP1 [54615] (1 superfamily)
    beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
  35. 256127d.35: Heme-binding protein A (HasA) [54620] (1 superfamily)
    beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
  36. 256136d.36: Chalcone isomerase [54625] (1 superfamily)
    beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
  37. 256159d.37: CBS-domain [54630] (1 superfamily)
    core: beta-alpha-beta(4); 2 layers: alpha/beta
  38. 256172d.38: Thioesterase/thiol ester dehydrase-isomerase [54636] (1 superfamily)
    core: beta-alpha-beta(4); 2 layers: alpha/beta
  39. 256200d.39: Dynein light chain 8 (DLC8) [54647] (1 superfamily)
    core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
  40. 256214d.40: CI-2 family of serine protease inhibitors [54653] (1 superfamily)
    alpha+beta sandwich; loop across free side of beta-sheet
  41. 256251d.41: alpha/beta-Hammerhead [54664] (5 superfamilies)
    core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
  42. 256353d.42: POZ domain [54694] (1 superfamily)
    core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
  43. 256425d.43: Elongation factor Ts (EF-Ts), dimerisation domain [54712] (1 superfamily)
    beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
  44. 256440d.44: Fe,Mn superoxide dismutase (SOD), C-terminal domain [54718] (1 superfamily)
    alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
  45. 256590d.45: ClpS-like [54735] (1 superfamily)
    beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
  46. 256611d.46: Transcription-state regulator AbrB, the N-terminal DNA recognition domain [54741] (1 superfamily)
    beta-alpha-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
  47. 256618d.47: Ribosomal protein L11, N-terminal domain [54746] (1 superfamily)
    beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
  48. 256624d.48: Anti-LPS factor/recA domain [54751] (2 superfamilies)
    alpha-beta(3)-alpha(2); 2 layers, alpha/beta
  49. 256644d.49: Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54761] (1 superfamily)
    (beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
  50. 256657d.50: dsRBD-like [54767] (3 superfamilies)
    alpha-beta(3)-alpha; 2 layers: alpha/beta
  51. 256747d.51: Eukaryotic type KH-domain (eKH-domain) [54790] (1 superfamily)
    beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
  52. 256779d.52: Alpha-lytic protease prodomain-like [54805] (6 superfamilies)
    core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
  53. 256856d.53: Ribosomal protein S3 C-terminal domain [54820] (1 superfamily)
    alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
  54. 256875d.54: Enolase N-terminal domain-like [54825] (1 superfamily)
    beta(3)-alpha(3); meander and up-and-down bundle
  55. 256982d.55: Ribosomal protein L22 [54842] (1 superfamily)
    beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
  56. 256999d.56: GroEL-intermediate domain like [54848] (1 superfamily)
    3-helical bundle packed against 3-stranded mixed beta-sheet
  57. 257055d.57: DNA damage-inducible protein DinI [54856] (1 superfamily)
    beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
  58. 257061d.58: Ferredoxin-like [54861] (44 superfamilies)
    alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
  59. 258337d.59: Ribosomal protein L30p/L7e [55128] (1 superfamily)
    core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity with the ferredoxin-like fold
  60. 258354d.60: Probable bacterial effector-binding domain [55135] (1 superfamily)
    duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)
  61. 258374d.61: tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase [55143] (1 superfamily)
    duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
  62. 258385d.62: Pepsin inhibitor-3 [55148] (1 superfamily)
    duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
  63. 258392d.63: mRNA triphosphatase CET1 [55153] (1 superfamily)
    duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
  64. 258403d.64: eIF1-like [55158] (1 superfamily)
    beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243
  65. 258412d.65: Hedgehog/DD-pepidase [55165] (1 superfamily)
    alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
  66. 258422d.66: Alpha-L RNA-binding motif [55173] (1 superfamily)
    alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta
  67. 258463d.67: RRF/tRNA synthetase additional domain-like [55185] (3 superfamilies)
    core:alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
  68. 258489d.68: IF3-like [55199] (7 superfamilies)
    beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
  69. 258578d.70: Yest killer toxins [55220] (1 superfamily)
    beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection
  70. 258592d.71: Cell division protein MinE topological specificity domain [55228] (1 superfamily)
    dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
  71. 258599d.72: Cyanase C-terminal domain [55233] (1 superfamily)
    intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
  72. 258624d.73: RuBisCO, small subunit [55238] (1 superfamily)
    alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
  73. 258710d.74: DCoH-like [55247] (4 superfamilies)
    beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
  74. 258828d.75: MutS N-terminal domain-like [55266] (2 superfamilies)
    beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
  75. 258850d.76: GYF domain [55276] (1 superfamily)
    beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
  76. 258857d.77: Ribosomal protein L5 [55281] (1 superfamily)
    beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654
  77. 258876d.78: RPB5-like RNA polymerase subunit [55286] (1 superfamily)
    core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta
  78. 258900d.79: Bacillus chorismate mutase-like [55297] (5 superfamilies)
    core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
  79. 259074d.80: Tautomerase/MIF [55330] (1 superfamily)
    (beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
    generally forms trimers with three closely packed beta-sheets
  80. 259192d.81: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain [55346] (1 superfamily)
    core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
  81. 259449d.82: N domain of copper amine oxidase-like [55382] (2 superfamilies)
    alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet
  82. 259483d.83: Bactericidal permeability-increasing protein, BPI [55393] (1 superfamily)
    beta-alpha-beta(5)-alpha-beta2; 2 layers: alpha/beta; antiparallel sheet
  83. 259492d.84: Subtilisin inhibitor [55398] (1 superfamily)
    alpha+beta sandwich
  84. 259503d.85: RNA bacteriophage capsid protein [55404] (1 superfamily)
    6-standed beta-sheet followed with 2 helices; meander
  85. 259639d.86: Translation initiation factor eIF4e [55417] (1 superfamily)
    beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478
  86. 259657d.87: CO dehydrogenase flavoprotein C-domain-like [55423] (2 superfamilies)
    core: beta(3,4)-alpha(3); alpha+beta sandwich
  87. 259811d.88: SRF-like [55454] (1 superfamily)
    alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet
  88. 259836d.89: Origin of replication-binding domain, RBD-like [55463] (1 superfamily)
    alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers:a/b/a; antiparallel sheet 41325
  89. 259869d.90: NADH oxidase/flavin reductase [55468] (1 superfamily)
    core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243
  90. 259918d.91: N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [55480] (1 superfamily)
    alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123
  91. 259924d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  92. 260293d.93: SH2-like [55549] (1 superfamily)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
  93. 260502d.94: HPr-like [55593] (2 superfamilies)
    beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423
  94. 260550d.95: Homing endonuclease-like [55603] (2 superfamilies)
    alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243
  95. 260606d.96: T-fold [55619] (1 superfamily)
    beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
    tunnel-shaped: its known members form wide oligomeric barrels different sizes
  96. 260732d.97: Cell cycle regulatory proteins [55636] (1 superfamily)
    beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
    can form strand-exchange dimers
  97. 260759d.98: beta-lactamase-inhibitor protein, BLIP [55647] (1 superfamily)
    alpha(2)-beta(4); 2 layers: alpha/beta
  98. 260766d.99: Ribosomal protein L9 C-domain [55652] (1 superfamily)
    alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta
  99. 260772d.100: L9 N-domain-like [55657] (1 superfamily)
    beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha
  100. 260783d.101: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5 [55665] (1 superfamily)
    beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134
  101. 260792d.102: Regulatory factor Nef [55670] (1 superfamily)
    alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha
  102. 260803d.103: Mosquitocidal delta-endotoxin CytB [55675] (1 superfamily)
    core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a
  103. 260809d.104: Class II aaRS and biotin synthetases [55680] (1 superfamily)
    contains large mixed beta-sheet
  104. 260967d.105: Clathrin adaptor appendage domain [55710] (1 superfamily)
    beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet
  105. 260984d.106: Sterol carrier protein, SCP [55717] (1 superfamily)
    alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145
  106. 260995d.107: Ran-binding protein mog1p [55723] (1 superfamily)
    (beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654
  107. 261001d.108: Acyl-CoA N-acyltransferases (Nat) [55728] (1 superfamily)
    3 layers: a/b/a; contains mixed beta-sheet
  108. 261128d.109: Gelsolin-like [55752] (2 superfamilies)
    3 layers: a/b/a; contains mixed beta-sheet
  109. 261219d.110: Profilin-like [55769] (5 superfamilies)
    core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha
  110. 261362d.111: PR-1-like [55796] (1 superfamily)
    alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
  111. 261371d.112: Phoshotransferase/anion transport protein [55803] (1 superfamily)
    beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342; loop crossing
  112. 261392d.113: Nudix [55810] (1 superfamily)
    beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
    contains beta-grasp motif
  113. 261435d.114: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [55815] (1 superfamily)
    core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425
  114. 261450d.115: YrdC/RibB [55820] (1 superfamily)
    core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other
  115. 261478d.116: Hypothetical protein HI1434 (YbaK homologue) [55825] (1 superfamily)
    core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet
  116. 261486d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  117. 261666d.118: N-acetylmuramoyl-L-alanine amidase-like [55845] (1 superfamily)
    contains mixed beta-sheet
  118. 261676d.120: Cytochrome b5 [55855] (1 superfamily)
    small, heme-binding fold
  119. 261738d.121: DNA topoisomerase I domain [55868] (1 superfamily)
    beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3
  120. 261744d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
    8-stranded mixed beta-sheet; 2 layers: alpha/beta
  121. 261830d.123: Sporulation responce regulatory protein Spo0B [55889] (1 superfamily)
    core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)
  122. 261841d.124: Ribonuclease Rh-like [55894] (1 superfamily)
    alpha+beta fold
  123. 261864d.125: Ornithine decarboxylase C-terminal domain [55903] (1 superfamily)
    complex alpha+beta motif
  124. 261872d.126: Pentein, beta/alpha-propeller [55908] (1 superfamily)
    duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis
  125. 261903d.127: Creatinase/aminopeptidase [55919] (1 superfamily)
    duplication: composed of two very similar alpha+beta folds
  126. 261944d.128: Glutamine synthase/guanido kinase [55930] (1 superfamily)
  127. 262082d.129: TBP-like [55944] (4 superfamilies)
    beta-alpha-beta(4)-alpha
  128. 262283d.130: S-adenosylmethionine synthetase [55972] (1 superfamily)
    duplication: consists of 3 similar intertwined domains
    structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
  129. 262319d.131: DNA clamp [55978] (1 superfamily)
    contains two helices and two beta sheets
    duplication: fold has internal pseudo two-fold symmetry
  130. 262389d.133: Molybdemum cofactor-binding domain [56002] (1 superfamily)
    beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops
  131. 262429d.134: Sulfite reductase hemoprotein (SiRHP), domains 2 and 4 [56013] (1 superfamily)
    beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection bettween strands 2 and 3
  132. 262458d.135: The spindle assembly checkpoint protein mad2 [56018] (1 superfamily)
    core: alpha(2)-beta(2)-alpha-beta; mixed sheet: order 213
  133. 262469d.136: Phospholipase D/nuclease [56023] (1 superfamily)
    beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234
  134. 262494d.137: Monooxygenase (hydroxylase) regulatory protein [56028] (1 superfamily)
    corner-like structure formed by two sheets and filled in with 2-3 helices
  135. 262509d.138: B3/B4 domain of PheRS, PheT [56036] (1 superfamily)
    3 layers: beta/beta/alpha sandwich
  136. 262519d.139: Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain [56041] (1 superfamily)
    3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold
  137. 262528d.140: Ribosomal protein S8 [56046] (1 superfamily)
    consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
  138. 262555d.141: Ribosomal protein L6 [56052] (1 superfamily)
    consists of two beta-sheets and one alpha-helix packed around single core
  139. 262579d.142: ATP-grasp [56058] (2 superfamilies)
    Consists of two subdomains with different alpha+beta folds
    shares functional and structural similarities with the PIPK and protein kinase superfamilies
  140. 262779d.143: SAICAR synthase-like [56103] (1 superfamily)
    consists of two alpha+beta subdomains
  141. 262793d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  142. 263140d.145: FAD-binding domain [56175] (1 superfamily)
    consists of two alpha+beta subdomains
  143. 263225d.146: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain [56193] (1 superfamily)
    consists of two alpha+beta subdomains
  144. 263236d.147: Methenyltetrahydromethanopterin cyclohydrolase [56198] (1 superfamily)
    consists of two alpha+beta subdomains
  145. 263242d.148: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap) [56203] (1 superfamily)
    consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit
  146. 263253d.149: Nitrile hydratase alpha chain [56208] (1 superfamily)
    4 layers a/b/b/a; inside is a sandwich of two 2-stranded beta-sheets
  147. 263267d.150: 4'-phosphopantetheinyl transferase [56213] (1 superfamily)
    beta-alpha(3)-beta(2) motif
  148. 263297d.151: DNase I-like [56218] (1 superfamily)
    contains beta-sandwich; duplication of alpha+beta motif
  149. 263326d.152: Aldehyde ferredoxin oxidoreductase, N-terminal domain [56227] (1 superfamily)
    contains sandwich; duplication of alpha+beta motif with single mixed sheet
    motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel
  150. 263343d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  151. 263729d.154: L-aminopeptidase D-Ala-esterase/amidase [56265] (1 superfamily)
    duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha
  152. 263740d.155: Histidine decarboxylase [56270] (1 superfamily)
    contains "silk" beta-sandwich flanked on both sides with alpha-helices
  153. 263762d.156: S-adenosylmethionine decarboxylase [56275] (1 superfamily)
    duplication of beta-alpha-beta(4)-alpha-beta-alpha-beta(2) motif; 4 layers a/b/b/a; antiparallel beta-sheets: order 23451687
  154. 263779d.157: Metallo-hydrolase/oxidoreductase [56280] (1 superfamily)
    duplication of beta(4)-alpha-beta-alpha motif; 4 layers a/b/b/a; mixed beta-sheets
  155. 263837d.159: Metallo-dependent phosphatases [56299] (1 superfamily)
    4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
  156. 263905d.160: Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase [56316] (1 superfamily)
    4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
  157. 263926d.161: ADC synthase [56321] (1 superfamily)
    duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets
  158. 263945d.162: Lactate & malate dehydrogenases, C-terminal domain [56326] (1 superfamily)
    unusual fold, defines family
  159. 264081d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
    core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
  160. 264135d.164: SMAD MH1 domain [56365] (1 superfamily)
    consists of four alpha-helices and three beta-ribbons
  161. 264142d.165: Ribosome inactivating proteins (RIP) [56370] (1 superfamily)
    contains mixed beta-sheet
  162. 264232d.166: ADP-ribosylation [56398] (1 superfamily)
    unusual fold
  163. 264339d.167: Peptide deformylase [56419] (1 superfamily)
    alpha-beta(5)-alpha; 3 layers: a/b/a; meander beta-sheet wraps around the C-terminal alpha-helix
  164. 264398d.168: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [56424] (1 superfamily)
    unusual fold
  165. 264459d.169: C-type lectin-like [56435] (1 superfamily)
    unusual fold
  166. 264773d.170: SRCR-like [56486] (2 superfamilies)
    unusual fold; disulphide-rich; core: beta-x-alpha-beta-loop-beta
  167. 264784d.171: Fibrinogen C-terminal domain-like [56495] (1 superfamily)
    unusual fold
  168. 264868d.172: gp120 core [56501] (1 superfamily)
    unusual fold
  169. 264876d.173: Methionine synthase activation domain-like [56506] (1 superfamily)
    unusual fold; core: beta-alpha(2)-beta(2)-alpha(2)-beta-alpha-beta; antiparallel beta-sheet: order 12354
  170. 264889d.174: Nitric oxide (NO) synthase oxygenase domain [56511] (1 superfamily)
    unusual fold
  171. 265029d.175: Penicillin binding protein dimerisation domain [56518] (1 superfamily)
    unusual fold
  172. 265053d.176: Sulfite oxidase, middle catalytic domain [56523] (1 superfamily)
    unusual fold; contains 3 layers of beta-sheet structure and a beta-grasp like motif
  173. 265060d.177: FAH [56528] (1 superfamily)
    unusual fold; contains 3 layers of beta-sheet structure
  174. 265091d.178: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [56533] (1 superfamily)
    unusual fold
  175. 265122d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
    unusual fold
  176. 265168d.180: Conserved core of transcriptional regulatory protein vp16 [56547] (1 superfamily)
    unusual fold
  177. 265174d.181: Insert subdomain of RNA polymerase alpha subunit [56552] (1 superfamily)
    unusual fold; contains a left-handed beta-alpha-beta unit
  178. 265197d.182: Baseplate structural protein gp11 [56557] (1 superfamily)
    unusual fold; trimer
  179. 265205d.183: Major capsid protein gp5 [56562] (1 superfamily)
    unusual fold
  180. 265217d.184: Non-globular alpha+beta subunits of globular proteins [56567] (1 superfamily)
  181. 265229d.185: LuxS/MPP-like metallohydrolase [63410] (1 superfamily)
    core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta
  182. 265373d.186: Head-to-tail joining protein W, gpW [64209] (1 superfamily)
    alpha-beta(2)-alpha; antiparallel hairpin
  183. 265379d.187: Photosystem I subunit PsaD [64233] (1 superfamily)
    beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
  184. 265385d.188: Prokaryotic ribosomal protein L17 [64262] (1 superfamily)
    alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;
  185. 265399d.189: PX domain [64267] (1 superfamily)
    beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
  186. 265414d.190: Chorismate lyase [64287] (1 superfamily)
    duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654
  187. 265424d.192: YlxR-like [64375] (1 superfamily)
    alpha+beta fold; could have evolved from a glucocorticoid receptor-like zinc finger domain
  188. 265430d.193: Hsp33 domain [64396] (1 superfamily)
    3 layers: beta/alpha/beta; buried helix
  189. 265437d.194: Type 1 cytotoxic necrotizing factor, catalytic domain [64437] (1 superfamily)
    4 layers: alpha/beta/beta/alpha; mixed beta sheets
  190. 265444d.195: YopH tyrosine phosphatase N-terminal domain [64448] (1 superfamily)
    consists of four alpha-helices and two beta-hairpins
  191. 265453d.196: Outer capsid protein sigma 3 [64464] (1 superfamily)
    unusual fold
  192. 265463d.197: Protein-L-isoaspartyl O-methyltransferase, C-terminal domain [68929] (1 superfamily)
    beta-alpha-beta(4)-alpha-beta(2); 3 layers: beta/alpha/beta; buried helix
  193. 265470d.198: Secretion chaperone-like [69634] (2 superfamilies)
    alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
  194. 265519d.199: DNA-binding C-terminal domain of the transcription factor MotA [69651] (1 superfamily)
    alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
  195. 265530d.200: Integrin beta tail domain [69686] (1 superfamily)
    alpha-beta-loop-beta(3); loop across free side of beta-sheet
  196. 265538d.201: SRP19 [69694] (1 superfamily)
    beta-alpha-beta(2)-alpha; 2 layers: alpha/beta
  197. 265551d.202: Transcription factor NusA, N-terminal domain [69704] (1 superfamily)
    alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet
  198. 265560d.203: DsrC, the gamma subunit of dissimilatory sulfite reductase [69720] (1 superfamily)
    beta(3)-alpha(5); meander beta-sheet packed against array of helices
  199. 265566d.204: Ribosome binding protein Y (YfiA homologue) [69753] (1 superfamily)
    beta-alpha-beta(3)-alpha; 2 layers; mixed sheet 1234, strand 3 is antiparallel to the rest
  200. 265575d.205: GTP cyclohydrolase I feedback regulatory protein, GFRP [69760] (1 superfamily)
    beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta, antiparallel beta-sheet: order 342165
  201. 265605d.206: YggU-like [69785] (1 superfamily)
    beta(2)-loop-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243; some similarity to the Homing endonuclease-like fold
  202. 265614d.207: Thymidylate synthase-complementing protein Thy1 [69795] (1 superfamily)
    complex alpha+beta fold; contains antiparallel 5-stranded beta-sheet: order 12354
  203. 265623d.208: MTH1598-like [69818] (1 superfamily)
    beta(2)-alpha-beta-alpha-beta(4); 3 layers: beta/alpha/beta; some similarity to the Hsp33 fold
  204. 265632d.209: LCCL domain [69847] (1 superfamily)
    unusual fold
  205. 265638d.210: Argininosuccinate synthetase, C-terminal domain [69863] (1 superfamily)
    unusual fold
  206. 265660d.211: beta-hairpin-alpha-hairpin repeat [74651] (2 superfamilies)
    multiple repeats of beta(2)-alpha(2) motif
  207. 265731d.212: TolA/TonB C-terminal domain [74652] (1 superfamily)
    beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit in unswapped monomer
  208. 265744d.213: VSV matrix protein [75403] (1 superfamily)
    beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
  209. 265750d.214: Hypothetical protein MTH1880 [75411] (1 superfamily)
    beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
  210. 265757d.215: Smc hinge domain [75552] (1 superfamily)
    consists of 2 different alpha+beta subdomains; forms subdomain-swapped dimers
  211. 265772d.216: Rotavirus NSP2 fragment, N-terminal domain [75573] (1 superfamily)
    consists of six alpha-helices and two beta-hairpins
  212. 265778d.217: SAND domain-like [63762] (1 superfamily)
    core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
  213. 265789d.218: Nucleotidyltransferase [81302] (1 superfamily)
    core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
  214. 265939d.219: Protein serine/threonine phosphatase 2C, catalytic domain [81607] (1 superfamily)
    4 layers: alpha/beta/beta/alpha; antiparallel beta sheets
  215. 265945d.220: Calcium ATPase, ATP-binding domain N [81661] (1 superfamily)
  216. 265954d.221: Nuclease A inhibitor (NuiA) [82601] (1 superfamily)
    alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
  217. 265961d.222: YbaB-like [82606] (1 superfamily)
    core: alpha-(beta)3-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
  218. 265967d.223: Polo domain [82614] (1 superfamily)
    beta(5)-alpha-beta; forms swapped dimer with two 6-stranded antiparallel beta sheets; order [6]123[4][5]
  219. 265974d.224: SufE (YhnA) [82648] (1 superfamily)
    alpha2-beta3-alpha3; 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
  220. 265981d.225: Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains [82713] (1 superfamily)
    Intertwined pseudo hexamer of an alpha+beta motif
  221. 265988d.226: GIY-YIG endonuclease [82770] (1 superfamily)
    beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)
  222. 265996d.227: Ohr/OsmC resistance proteins [82783] (1 superfamily)
    swapped dimer of beta(3)-alpha-beta(2)-alpha(2)-beta subunits; mixed beta-sheet; order: 321[4][5][6]; buried helix
  223. 266003d.228: Replication modulator SeqA, C-terminal DNA-binding domain [82807] (1 superfamily)
    consists of seven alpha-helices and three-stranded beta-sheet
  224. 266010d.229: Putative cell cycle protein MesJ, middle and C-terminal domain [82828] (1 superfamily)
    consists of two different alpha+beta domains

More info for Class d: Alpha and beta proteins (a+b)

Timeline for Class d: Alpha and beta proteins (a+b):