SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Class d: Alpha and beta proteins (a+b)

  1. Root: SCOP 1.55
  2. 28523Class d: Alpha and beta proteins (a+b) [53931] (184 folds)

Folds:

  1. 28524d.1: Microbial ribonucleases [53932] (1 superfamily)
  2. 28759d.2: Lysozyme-like [53954] (1 superfamily)
  3. 29566d.3: Cysteine proteinases [54000] (1 superfamily)
  4. 29757d.4: His-Me finger endonucleases [54059] (1 superfamily)
  5. 29802d.5: RNase A-like [54075] (1 superfamily)
  6. 29966d.6: Prion protein domain [54097] (1 superfamily)
  7. 29994d.7: LysM domain [54105] (1 superfamily)
  8. 30001d.8: Urease, gamma-subunit [54110] (1 superfamily)
  9. 30036d.9: IL8-like [54116] (2 superfamilies)
  10. 30212d.10: DNA-binding domain [54170] (1 superfamily)
  11. 30234d.11: Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1 superfamily)
  12. 30245d.12: Ribosomal proteins L23 and L15e [54188] (1 superfamily)
  13. 30255d.13: HIT-like [54196] (1 superfamily)
  14. 30320d.14: Ribosomal protein S5 domain 2-like [54210] (1 superfamily)
  15. 30383d.15: beta-Grasp (ubiquitin-like) [54235] (9 superfamilies)
  16. 30799d.16: FAD-linked reductases, C-terminal domain [54372] (1 superfamily)
  17. 30954d.17: Cystatin-like [54402] (5 superfamilies)
  18. 31152d.18: Transcriptional coactivator PC4 C-terminal domain [54446] (1 superfamily)
  19. 31165d.19: MHC antigen-recognition domain [54451] (1 superfamily)
  20. 31383d.20: Ubiquitin conjugating enzyme [54494] (1 superfamily)
  21. 31406d.21: Diaminopimelate epimerase [54505] (1 superfamily)
  22. 31413d.22: Fluorescent proteins [54510] (1 superfamily)
  23. 31456d.23: Transcriptional factor tubby, C-terminal domain [54517] (1 superfamily)
  24. 31462d.24: Pilin [54522] (1 superfamily)
  25. 31471d.25: Acidic mitochondrial matrix protein p32 [54528] (1 superfamily)
  26. 31479d.26: FKBP-like [54533] (3 superfamilies)
  27. 31571d.27: Ribosomal protein S16 [54564] (1 superfamily)
  28. 31583d.28: Ribosomal protein S19 [54569] (1 superfamily)
  29. 31596d.29: Ribosomal protein L31e [54574] (1 superfamily)
  30. 31602d.30: Allophycocyanin linker chain (domain) [54579] (1 superfamily)
  31. 31609d.31: Cdc48 domain 2-like [54584] (1 superfamily)
  32. 31626d.32: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1 superfamily)
  33. 31698d.33: Bacterial protein-export protein SecB [54610] (1 superfamily)
  34. 31707d.34: DNA-binding domain of Mlu1-box binding protein MBP1 [54615] (1 superfamily)
  35. 31714d.35: Heme-binding protein A (HasA) [54620] (1 superfamily)
  36. 31723d.36: Chalcone isomerase [54625] (1 superfamily)
  37. 31732d.37: CBS-domain [54630] (1 superfamily)
  38. 31742d.38: Thioesterase/thiol ester dehydrase-isomerase [54636] (1 superfamily)
  39. 31762d.39: Dynein light chain 8 (DLC8) [54647] (1 superfamily)
  40. 31776d.40: CI-2 family of serine protease inhibitors [54653] (1 superfamily)
  41. 31812d.41: alpha/beta-Hammerhead [54664] (5 superfamilies)
  42. 31889d.42: POZ domain [54694] (1 superfamily)
  43. 31952d.43: Elongation factor Ts (EF-Ts), dimerisation domain [54712] (1 superfamily)
  44. 31967d.44: Fe,Mn superoxide dismutase (SOD), C-terminal domain [54718] (1 superfamily)
  45. 32058d.45: Ribosomal protein L7/12, C-terminal domain [54735] (1 superfamily)
  46. 32069d.46: Transcription-state regulator AbrB, the N-terminal DNA recognition domain [54741] (1 superfamily)
  47. 32076d.47: Ribosomal protein L11, N-terminal domain [54746] (1 superfamily)
  48. 32082d.48: Anti-LPS factor/recA domain [54751] (2 superfamilies)
  49. 32098d.49: Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54761] (1 superfamily)
  50. 32111d.50: dsRBD-like [54767] (3 superfamilies)
  51. 32153d.51: KH-domain [54790] (1 superfamily)
  52. 32181d.52: Alpha-lytic protease prodomain-like [54805] (3 superfamilies)
  53. 32222d.53: Ribosomal protein S3 C-terminal domain [54820] (1 superfamily)
  54. 32233d.54: Enolase N-terminal domain-like [54825] (1 superfamily)
  55. 32304d.55: Ribosomal protein L22 [54842] (1 superfamily)
  56. 32312d.56: GroEL-like chaperone, intermediate domain [54848] (1 superfamily)
  57. 32360d.57: DNA damage-inducible protein DinI [54856] (1 superfamily)
  58. 32366d.58: Ferredoxin-like [54861] (36 superfamilies)
  59. 33217d.59: Ribosomal protein L30p/L7e [55128] (1 superfamily)
  60. 33227d.60: Probable bacterial effector-binding domain [55135] (1 superfamily)
  61. 33243d.61: tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase [55143] (1 superfamily)
  62. 33251d.62: Pepsin inhibitor-3 [55148] (1 superfamily)
  63. 33258d.63: mRNA triphosphatase CET1 [55153] (1 superfamily)
  64. 33269d.64: eIF1-like [55158] (1 superfamily)
  65. 33278d.65: Hedgehog/DD-pepidase [55165] (1 superfamily)
  66. 33288d.66: Alpha-L RNA-binding motif [55173] (1 superfamily)
  67. 33311d.67: RRF/tRNA synthetase additional domain-like [55185] (3 superfamilies)
  68. 33329d.68: IF3-like [55199] (2 superfamilies)
  69. 33366d.69: C-terminal domain of TolA [55215] (1 superfamily)
  70. 33372d.70: Yest killer toxins [55220] (1 superfamily)
  71. 33386d.71: Cell division protein MinE topological specificity domain [55228] (1 superfamily)
  72. 33393d.72: Cyanase C-terminal domain [55233] (1 superfamily)
  73. 33418d.73: RuBisCO, small subunit [55238] (1 superfamily)
  74. 33483d.74: DCoH-like [55247] (4 superfamilies)
  75. 33569d.75: MutS N-terminal domain-like [55266] (2 superfamilies)
  76. 33589d.76: GYF domain [55276] (1 superfamily)
  77. 33595d.77: Ribosomal protein L5 [55281] (1 superfamily)
  78. 33601d.78: RPB5-like RNA polymerase subunit [55286] (1 superfamily)
  79. 33616d.79: Bacillus chorismate mutase-like [55297] (4 superfamilies)
  80. 33714d.80: Tautomerase/MIF [55330] (1 superfamily)
  81. 33775d.81: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain [55346] (1 superfamily)
  82. 33949d.82: N domain of copper amine oxidase-like [55382] (2 superfamilies)
  83. 33981d.83: Bactericidal permeability-increasing protein, BPI [55393] (1 superfamily)
  84. 33990d.84: Subtilisin inhibitor [55398] (1 superfamily)
  85. 34001d.85: RNA bacteriophage capsid protein [55404] (1 superfamily)
  86. 34125d.86: Translation initiation factor eIF4e [55417] (1 superfamily)
  87. 34139d.87: CO dehydrogenase flavoprotein C-domain-like [55423] (2 superfamilies)
  88. 34248d.88: SRF-like [55454] (1 superfamily)
  89. 34267d.89: The origin DNA-binding domain of SV40 T-antigen [55463] (1 superfamily)
  90. 34274d.90: NADH oxidase/flavin reductase [55468] (1 superfamily)
  91. 34301d.91: N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [55480] (1 superfamily)
  92. 34307d.92: Zincin-like [55485] (2 superfamilies)
  93. 34525d.93: SH2-like [55549] (1 superfamily)
  94. 34701d.94: Histidine-containing phosphocarrier proteins (HPr) [55593] (1 superfamily)
  95. 34734d.95: Homing endonuclease-like [55603] (2 superfamilies)
  96. 34770d.96: T-fold [55619] (1 superfamily)
  97. 34875d.97: Cell cycle regulatory proteins [55636] (1 superfamily)
  98. d.98: beta-lactamase-inhibitor protein, BLIP [55647] (1 superfamily)
  99. 34908d.99: Ribosomal protein L9 C-domain [55652] (1 superfamily)
  100. 34914d.100: L9 N-domain-like [55657] (1 superfamily)
  101. 34924d.101: Polynucleotide phosporylase/guanosine pentaphospate synthase (PNPase/GPSI), domains 2 and 5 [55665] (1 superfamily)
  102. 34933d.102: Regulatory factor Nef [55670] (1 superfamily)
  103. 34944d.103: Mosquitocidal delta-endotoxin CytB [55675] (1 superfamily)
  104. 34950d.104: Class II aaRS and biotin synthetases [55680] (1 superfamily)
  105. 35063d.105: Clathrin adaptor appendage domain [55710] (1 superfamily)
  106. 35075d.106: Sterol carrier protein 2 (SCP2) [55717] (1 superfamily)
  107. 35083d.107: Ran-binding protein mog1p [55723] (1 superfamily)
  108. 35089d.108: Acyl-CoA N-acyltransferases (Nat) [55728] (1 superfamily)
  109. 35145d.109: Actin depolymerizing proteins [55752] (1 superfamily)
  110. 35199d.110: Profilin-like [55769] (3 superfamilies)
  111. 35273d.111: PR-1-like [55796] (1 superfamily)
  112. 35282d.112: IIA domain of mannitol-specific and ntr phosphotransherase EII [55803] (1 superfamily)
  113. 35295d.113: Nucleoside triphosphate pyrophosphorylase (MutT) [55810] (1 superfamily)
  114. 35302d.114: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [55815] (1 superfamily)
  115. 35310d.115: Hypothetica protein YrdC [55820] (1 superfamily)
  116. 35317d.116: Hypothetica protein HI1434 (YbaK homologue) [55825] (1 superfamily)
  117. 35325d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
  118. 35471d.118: Bacteriophage T7 lysozyme (Zn amidase) [55845] (1 superfamily)
  119. d.119: Streptomyces lysozyme [55850] (1 superfamily)
  120. 35484d.120: Cytochrome b5 [55855] (1 superfamily)
  121. 35524d.121: DNA topoisomerase I domain [55868] (1 superfamily)
  122. 35530d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
  123. 35567d.123: Sporulation responce regulatory protein Spo0B [55889] (1 superfamily)
  124. 35578d.124: Ribonuclease Rh-like [55894] (1 superfamily)
  125. 35590d.125: Ornithine decarboxylase C-terminal domain [55903] (1 superfamily)
  126. 35598d.126: Pentein, beta/alpha-propeller [55908] (1 superfamily)
  127. 35625d.127: Creatinase/aminopeptidase [55919] (1 superfamily)
  128. 35661d.128: Glutamine synthase/guanidino kinase catalytic domain [55930] (1 superfamily)
  129. 35720d.129: TBP-like [55944] (3 superfamilies)
  130. 35862d.130: S-adenosylmethionine synthetase [55972] (1 superfamily)
  131. 35898d.131: DNA clamp [55978] (1 superfamily)
  132. 35957d.132: Mitochondrial processing peptidase, MPP [55993] (1 superfamily)
  133. 35980d.133: Molybdemum cofactor-binding domain [56002] (1 superfamily)
  134. 36002d.134: Sulfite reductase hemoprotein (SiRHP), domains 2 and 4 [56013] (1 superfamily)
  135. 36031d.135: The spindle assembly checkpoint protein mad2 [56018] (1 superfamily)
  136. 36037d.136: Phospholipase D/nuclease [56023] (1 superfamily)
  137. 36044d.137: Monooxygenase (hydroxylase) regulatory protein [56028] (1 superfamily)
  138. 36055d.138: B3/B4 domain of PheRS, PheT [56036] (1 superfamily)
  139. 36064d.139: Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain [56041] (1 superfamily)
  140. 36073d.140: Ribosomal protein S8 [56046] (1 superfamily)
  141. 36089d.141: Ribosomal protein L6 [56052] (1 superfamily)
  142. 36099d.142: ATP-grasp [56058] (2 superfamilies)
  143. 36257d.143: SAICAR synthase-like [56103] (1 superfamily)
  144. 36268d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
  145. 36457d.145: FAD-binding domain [56175] (1 superfamily)
  146. 36518d.146: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain [56193] (1 superfamily)
  147. 36527d.147: Methenyltetrahydromethanopterin cyclohydrolase [56198] (1 superfamily)
  148. 36533d.148: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap) [56203] (1 superfamily)
  149. 36544d.149: Nitrile hydratase alpha chain [56208] (1 superfamily)
  150. 36555d.150: 4'-Phosphopantetheinyl transferase SFP [56213] (1 superfamily)
  151. 36561d.151: DNase I-like [56218] (1 superfamily)
  152. 36585d.152: Aldehyde ferredoxin oxidoreductase, N-terminal domain [56227] (1 superfamily)
  153. 36602d.153: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56234] (1 superfamily)
  154. 36849d.154: L-aminopeptidase D-Ala-esterase/amidase [56265] (1 superfamily)
  155. 36860d.155: Histidine decarboxylase [56270] (1 superfamily)
  156. 36868d.156: S-adenosylmethionine decarboxylase [56275] (1 superfamily)
  157. 36875d.157: Metallo-hydrolase/oxidoreductase [56280] (1 superfamily)
  158. 36921d.158: Protein serine/threonine phosphatase 2C [56294] (1 superfamily)
  159. 36927d.159: Metallo-dependent phosphatases [56299] (1 superfamily)
  160. 36966d.160: Nitrilase/N-carbamyl-D-aminoacid amidohydrolase [56316] (1 superfamily)
  161. 36973d.161: Anthranilate synthase aminodeoxyisochorismate synthase/lyase subunit TrpE [56321] (1 superfamily)
  162. 36979d.162: Lactate & malate dehydrogenases, C-terminal domain [56326] (1 superfamily)
  163. 37061d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
  164. 37104d.164: SMAD MH1 domain [56365] (1 superfamily)
  165. 37111d.165: Ribosome inactivating proteins (RIP) [56370] (1 superfamily)
  166. 37191d.166: ADP-ribosylation [56398] (1 superfamily)
  167. 37264d.167: Peptide deformylase [56419] (1 superfamily)
  168. 37295d.168: Succinate dehydrogenase/fumarate reductase catalytic domain [56424] (1 superfamily)
  169. 37323d.169: C-type lectin-like [56435] (1 superfamily)
  170. 37502d.170: SRCR-like [56486] (2 superfamilies)
  171. 37513d.171: Fibrinogen C-terminal domains [56495] (1 superfamily)
  172. 37557d.172: gp120 core [56501] (1 superfamily)
  173. 37565d.173: Methionine synthase (activation domain) [56506] (1 superfamily)
  174. 37571d.174: Nitric oxide (NO) synthase oxygenase domain [56511] (1 superfamily)
  175. 37642d.175: Penicillin-binding protein 2x (pbp-2x), N-terminal domain [56518] (1 superfamily)
  176. 37650d.176: Sulfite oxidase, middle catalytic domain [56523] (1 superfamily)
  177. 37657d.177: Fumarylacetoacetate hydrolase, FAH [56528] (1 superfamily)
  178. 37670d.178: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [56533] (1 superfamily)
  179. 37690d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
  180. d.180: Conserved core of transcriptional regulatory protein vp16 [56547] (1 superfamily)
  181. 37718d.181: Insert subdomain of RNA polymerase alpha subunit N-terminal domain [56552] (1 superfamily)
  182. 37727d.182: Baseplate structural protein gp11 [56557] (1 superfamily)
  183. 37735d.183: Major capsid protein gp5 [56562] (1 superfamily)
  184. 37747d.184: Non-globular alpha beta subunits of globular proteins [56567] (1 superfamily)

More info for Class d: Alpha and beta proteins (a+b)

Timeline for Class d: Alpha and beta proteins (a+b):