Lineage for Family c.37.1.8: G proteins

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2109203Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2109204Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families) (S)
    division into families based on beta-sheet topologies
  5. 2110099Family c.37.1.8: G proteins [52592] (79 protein domains)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Protein Domains:

  1. 2110100ADP-ribosylation factor [52614] (16 species)
    1. 2110101Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)
    2. 2110103Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)
    3. 2110106Species Human (Homo sapiens) [TaxId:9606] [142220] (2 PDB entries)
    4. 2110110Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (14 PDB entries)
      Uniprot P32889
    5. 2110135Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry)
      Uniprot P18085 3-177
    6. 2110138Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries)
    7. 2110145Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (3 PDB entries)
    8. 2110154Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (1 PDB entry)
      Uniprot Q9Y689 2-178
    9. 2110156Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry)
      Uniprot Q96KC2 6-173
    10. 2110158Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry)
      Uniprot Q96BM9 18-181
    11. 2110160Species Human (Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry)
      Uniprot Q9NVJ2 18-182
    12. 2110162Species Mouse (Mus musculus) [TaxId:10090] [225429] (3 PDB entries)
    13. 2110169Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (5 PDB entries)
    14. 2110177Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (3 PDB entries)
    15. 2110181Species Norway rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)
    16. 2110185Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [189615] (1 PDB entry)
  2. 2110188CDC42 [52619] (2 species)
    1. 2110189Species Human (Homo sapiens) [TaxId:9606] [52620] (30 PDB entries)
    2. 2110232Species Mouse (Mus musculus) [TaxId:10090] [159559] (1 PDB entry)
  3. 2110235Centaurin gamma 1, G domain [142249] (1 species)
  4. 2110238cH-p21 Ras protein [52593] (1 species)
  5. 2110367Chloroplast protein translocon GTPase Toc34 [69485] (1 species)
  6. 2110372di-Ras1 [142277] (1 species)
  7. 2110378di-Ras2 [142267] (1 species)
  8. 2110381Dynamin G domain [69488] (2 species)
    the family common core is decorated with large insertions
    1. 2110382Species Norway rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry)
      Uniprot P21575 6-304
      Dynamin-1
    2. 2110384Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)
  9. 2110387Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (2 species)
    1. 2110388Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82405] (13 PDB entries)
      Uniprot P32324
    2. 2110414Species Human (Homo sapiens) [TaxId:9606] [268001] (1 PDB entry)
  10. 2110416Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu
    1. 2110417Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries)
    2. 2110424Species Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries)
      Uniprot P35021
  11. 2110429Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species)
    has internal nucleotide exchange factor built in as an insertion subdomain
    1. 2110430Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries)
      residues 160-252 comprise insertion subdomain
    2. 2110441Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (2 PDB entries)
      Uniprot Q5SI76 1-267
      TTHA1498
  12. 2110444Elongation factor SelB, N-terminal domain [117537] (1 species)
  13. 2110458Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)
    1. 2110459Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries)
      Uniprot P49410 56-452
    2. 2110465Species Escherichia coli [TaxId:562] [52627] (10 PDB entries)
      Uniprot P02990
    3. 2110482Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)
    4. 2110491Species Thermus thermophilus [TaxId:274] [52629] (4 PDB entries)
  14. 2110500Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species)
  15. 2110505GTP-binding protein engB [142257] (1 species)
  16. 2110508GTP-binding protein GEM [142289] (1 species)
  17. 2110513GTP-binding protein PH0525 [142251] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
  18. 2110516GTP-binding protein RheB [142275] (2 species)
    1. 2110517Species Human (Homo sapiens) [TaxId:9606] [142276] (3 PDB entries)
      Uniprot Q15382 3-169
    2. 2110522Species Norway rat (Rattus norvegicus) [TaxId:10116] [255395] (1 PDB entry)
  19. 2110524GTPase Era, N-terminal domain [52637] (3 species)
    1. 2110525Species Escherichia coli K-12 [TaxId:83333] [224886] (1 PDB entry)
    2. 2110528Species Escherichia coli [TaxId:562] [52638] (2 PDB entries)
    3. 2110532Species Thermus thermophilus [TaxId:274] [117533] (2 PDB entries)
      Uniprot Q5SM23
  20. 2110535GTPase Ytp1 [110544] (1 species)
  21. 2110539Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (144211)
    1. 2110540Species Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)
    2. 2110542Species Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)
    3. 2110548Species Sulfolobus solfataricus [TaxId:2287] [142227] (10 PDB entries)
      Uniprot Q980A5 2-206
  22. 2110566Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)
  23. 2110571Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)
  24. 2110575Interferon-inducible GTPase [110546] (1 species)
    G domain is inserted in all-alpha domain
  25. 2110585Obg GTP-binding protein middle domain [82408] (2 species)
    1. 2110586Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)
    2. 2110589Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
      TT1381
  26. 2110591Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains
  27. 2110595Probable GTPase EngB [89667] (2 species)
    1. 2110596Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries)
      Uniprot P38424
    2. 2110602Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)
  28. 2110605Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species)
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
    1. 2110606Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry)
      Uniprot O34530
    2. 2110608Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry)
      Uniprot Q9X242 # TM1717
  29. 2110612Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
  30. 2110615Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)
  31. 2110618r-Ras [142273] (1 species)
  32. 2110621r-Ras2 [142281] (1 species)
  33. 2110624Rab-22a [142253] (1 species)
  34. 2110628Rab-33b [142279] (1 species)
  35. 2110632Rab-related protein Sec4 [52607] (1 species)
  36. 2110641Rab-related protein ypt7p [75199] (1 species)
  37. 2110645Rab11a [102362] (2 species)
    1. 2110646Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [159558] (2 PDB entries)
    2. 2110652Species Human (Homo sapiens) [TaxId:9606] [102363] (4 PDB entries)
  38. 2110659Rab11b [142237] (1 species)
  39. 2110663Rab14 [142271] (1 species)
  40. 2110667Rab18 [142233] (1 species)
  41. 2110670Rab1a [142241] (1 species)
  42. 2110678Rab21 [142285] (1 species)
  43. 2110683Rab23 [142231] (1 species)
  44. 2110686Rab26 [142259] (1 species)
  45. 2110689Rab27b [142263] (2 species)
    1. 2110690Species Human (Homo sapiens) [TaxId:9606] [142264] (1 PDB entry)
      Uniprot O00194 4-189
    2. 2110693Species Mouse (Mus musculus) [TaxId:10090] [256388] (1 PDB entry)
  46. 2110696Rab2a [142265] (1 species)
  47. 2110699Rab2b [142287] (1 species)
  48. 2110702Rab30 [142239] (1 species)
  49. 2110705Rab31 [142235] (1 species)
  50. 2110708Rab3a [52601] (1 species)
  51. 2110712Rab4a [142247] (1 species)
  52. 2110718Rab5a [82399] (1 species)
  53. 2110740Rab5c [52603] (1 species)
  54. 2110746Rab6 [52605] (2 species)
    1. 2110747Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry)
      Uniprot P20340 13-176
    2. 2110749Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)
  55. 2110751Rab7 [110540] (2 species)
    1. 2110752Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries)
      Uniprot P51149 7-182
    2. 2110758Species Norway rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries)
      Uniprot P09527
  56. 2110769Rab8a [142293] (2 species)
    1. 2110770Species Human (Homo sapiens) [TaxId:9606] [254870] (4 PDB entries)
    2. 2110785Species Mouse (Mus musculus) [TaxId:10090] [142294] (1 PDB entry)
      Uniprot P55258 3-175
  57. 2110788Rab9a [110537] (3 species)
    1. 2110789Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry)
      Uniprot P24408
    2. 2110792Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry)
      Uniprot P51151 2-175 # 100% sequence identity do the dog protein (Uniprot P24408 2-175)
    3. 2110795Species Mouse (Mus musculus) [TaxId:10090] [142229] (2 PDB entries)
      Uniprot Q9R0M6 4-175
  58. 2110798Rac [52595] (1 species)
  59. 2110827Rac3 [142255] (1 species)
  60. 2110830Rad [142295] (1 species)
  61. 2110833Ran [52609] (2 species)
    1. 2110834Species Dog (Canis familiaris) [TaxId:9615] [52610] (20 PDB entries)
      Uniprot P62825
    2. 2110854Species Human (Homo sapiens) [TaxId:9606] [52611] (43 PDB entries)
  62. 2110924Rap1A [52597] (1 species)
  63. 2110928Rap2a [52599] (1 species)
  64. 2110934Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species)
  65. 2110937Ras-related protein M-Ras (XRas) [142283] (1 species)
  66. 2110940Ras-related protein RalA [89662] (2 species)
    1. 2110941Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries)
      Uniprot P63320 # 100% identical to the mouse and rat orthologs (Uniprot P63321 P63322)
    2. 2110948Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries)
  67. 2110957RhoA [52612] (1 species)
  68. 2111001RhoB [142243] (1 species)
  69. 2111004RhoC [142245] (1 species)
  70. 2111011RhoE (RND3) [75201] (1 species)
  71. 2111016RhoQ [142261] (1 species)
  72. 2111020SAR1 [69483] (3 species)
    1. 2111021Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (2 PDB entries)
    2. 2111025Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)
    3. 2111028Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry)
      Uniprot Q9NR31 13-198
  73. 2111031Signal recognition particle receptor beta-subunit [89664] (2 species)
    1. 2111032Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)
    2. 2111034Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries)
      Uniprot P47758 63-269
  74. 2111037Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species)
  75. 2111040Transducin (alpha subunit) [52623] (4 species)
    common fold is interrupted with an all-alpha domain
    1. 2111041Species Cow (Bos taurus) [TaxId:9913] [52624] (18 PDB entries)
      Uniprot P04896 39-388
    2. 2111065Species Human (Homo sapiens) [TaxId:9606] [159560] (9 PDB entries)
    3. 2111082Species Mouse (Mus musculus) [TaxId:10090] [142225] (5 PDB entries)
      Uniprot P21279 38-66,184-354! Uniprot P27600 53-81,204-370! Uniprot P27601 47-75,202-372
    4. 2111091Species Norway rat (Rattus norvegicus) [TaxId:10116] [52625] (21 PDB entries)
      Uniprot P10824
  76. 2111118TrmE GTPase domain [117535] (1 species)
  77. 2111122YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. 2111123Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)
    2. 2111125Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
      HI0393
  78. 2111128Ypt51 [52621] (1 species)
  79. 2111131automated matches [190047] (28 species)
    not a true protein
    1. 2111132Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187069] (9 PDB entries)
    2. 2111150Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189771] (4 PDB entries)
    3. 2111157Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [187100] (2 PDB entries)
    4. 2111162Species Cryptosporidium parvum [TaxId:5807] [188236] (1 PDB entry)
    5. 2111164Species Dog (Canis familiaris) [TaxId:9615] [224975] (1 PDB entry)
    6. 2111167Species Entamoeba (Entamoeba histolytica) [TaxId:5759] [196360] (4 PDB entries)
    7. 2111175Species Entamoeba histolytica [TaxId:294381] [273048] (1 PDB entry)
    8. 2111178Species Escherichia coli K-12 [TaxId:83333] [256110] (3 PDB entries)
    9. 2111184Species Escherichia coli [TaxId:316385] [272313] (3 PDB entries)
    10. 2111191Species Escherichia coli [TaxId:469008] [187117] (4 PDB entries)
    11. 2111203Species Escherichia coli [TaxId:83333] [272301] (1 PDB entry)
    12. 2111206Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189700] (1 PDB entry)
    13. 2111209Species Human (Homo sapiens) [TaxId:9606] [186768] (168 PDB entries)
    14. 2111463Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [189514] (1 PDB entry)
    15. 2111465Species Mouse (Mus musculus) [TaxId:10090] [186896] (14 PDB entries)
    16. 2111482Species Norway rat (Rattus norvegicus) [TaxId:10116] [194536] (6 PDB entries)
    17. 2111492Species Oryza sativa [TaxId:39947] [259129] (1 PDB entry)
    18. 2111494Species Pea (Pisum sativum) [TaxId:3888] [188398] (1 PDB entry)
    19. 2111503Species Plasmodium falciparum [TaxId:36329] [188290] (1 PDB entry)
    20. 2111509Species Pyrococcus horikoshii OT3 [TaxId:70601] [187582] (1 PDB entry)
    21. 2111512Species Saccharomyces cerevisiae [TaxId:764097] [261066] (1 PDB entry)
    22. 2111514Species Sulfolobus solfataricus [TaxId:2287] [255781] (5 PDB entries)
    23. 2111527Species Sulfolobus solfataricus [TaxId:273057] [256083] (12 PDB entries)
    24. 2111540Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [188355] (9 PDB entries)
    25. 2111554Species Thermus aquaticus [TaxId:271] [254880] (1 PDB entry)
    26. 2111558Species Thermus thermophilus HB8 [TaxId:300852] [255082] (2 PDB entries)
    27. 2111561Species Thermus thermophilus [TaxId:274] [256283] (6 PDB entries)
    28. 2285746Species Candida albicans [TaxId:237561] [329047] (1 PDB entry)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins: